Victor Omoboyede
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View article: In-silico assessment of structure-based derivatives of phytochemicals from CHEESE webserver for anti-EZH2: advancing druggable lead identification for pancreatic cancer therapy
In-silico assessment of structure-based derivatives of phytochemicals from CHEESE webserver for anti-EZH2: advancing druggable lead identification for pancreatic cancer therapy Open
Enhancer of zeste homolog 2 (EZH2) is an epigenetic regulator implicated in various cancers, making it an attractive target for therapeutic intervention. In this study, we employed a structure-based drug discovery approach to identify and …
View article: Pharmacological assessment of <i>Coffea arabica</i> compounds as potential therapeutics for cervical cancer
Pharmacological assessment of <i>Coffea arabica</i> compounds as potential therapeutics for cervical cancer Open
Motivation Cervical cancer remains a leading cause of gynecological mortality, with existing treatments often limited by resistance and suboptimal efficacy. While Coffea arabica is rich in phytochemicals with reported anticancer properties…
View article: Network-based Toxicogenomics Approach to Unraveling the Influence of Lead and Cadmium Mixture on the Development and Progression of Hypertension
Network-based Toxicogenomics Approach to Unraveling the Influence of Lead and Cadmium Mixture on the Development and Progression of Hypertension Open
Heavy metals, generally characterized by high densities and atomic weights, are ubiquitous in the environment and are a public health concern due to the several health issues they pose to humans. Of all heavy metals, lead and cadmium among…
View article: Computer-aided analysis of quercetin mechanism of overcoming docetaxel resistance in docetaxel-resistant prostate cancer
Computer-aided analysis of quercetin mechanism of overcoming docetaxel resistance in docetaxel-resistant prostate cancer Open
Further analysis revealed epidermal growth factor receptor (EGFR) as the most pertinent target of quercetin in reversing DR in DRPC, while molecular docking simulation revealed an effective interaction between quercetin and EGFR. Ultimatel…
View article: In silico toxicogenomic data-mining to unraveling the influence of lead and cadmium co-exposure on molecular mechanisms involved in the development and progression of Hypertension
In silico toxicogenomic data-mining to unraveling the influence of lead and cadmium co-exposure on molecular mechanisms involved in the development and progression of Hypertension Open
Heavy metals, generally characterized by high densities and atomic weights, are ubiquitous in the environment and are of public health concern due to the several health issues they pose to humans. Of all heavy metals, lead and cadmium amon…
View article: Immunoinformatics Studies and Design of a Potential Multi-Epitope Peptide Vaccine to Combat the Fatal Visceral Leishmaniasis
Immunoinformatics Studies and Design of a Potential Multi-Epitope Peptide Vaccine to Combat the Fatal Visceral Leishmaniasis Open
Leishmaniasis is a neglected tropical disease caused by parasitic intracellular protozoa of the genus Leishmania. The visceral form of this disease caused by Leishmania donovani continues to constitute a major public health crisis, especia…