Michael Firbank
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View article: Differential diagnosis of dementias using in vivo MRI and data-driven disease progression modelling: a case study in Alzheimer’s disease and dementia with Lewy bodies
Differential diagnosis of dementias using in vivo MRI and data-driven disease progression modelling: a case study in Alzheimer’s disease and dementia with Lewy bodies Open
Alzheimer’s disease (AD) and Dementia with Lewy bodies (DLB) are neurodegenerative diseases often sharing clinical symptoms, causing frequent misdiagnoses. Using data from multiple cohorts we improve and apply the SuStaIn algorithm on regi…
View article: Changes in DTI-ALPS index and its associations with neuronal damage in Lewy body disease
Changes in DTI-ALPS index and its associations with neuronal damage in Lewy body disease Open
DTI-ALPS is reduced in DLB compared to healthy comparators. Our findings suggest that dysfunction of the glymphatic system may contribute to neuronal damage in Lewy body disease. However further research is needed to clarify the role of th…
View article: Cross-sectional and longitudinal associations between depressive symptoms and cognitive performance in mild cognitive impairment
Cross-sectional and longitudinal associations between depressive symptoms and cognitive performance in mild cognitive impairment Open
Background Depressive symptoms are common in mild cognitive impairment (MCI). These may be associated with poorer cognitive function and increased risks of dementia transition. Aims We aimed to examine the cognitive patterns associated wit…
View article: Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder
Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder Open
This study was supported by grants to S.R. from Alzheimer Society Canada (0000000082) and by Parkinson Canada (PPG-2023-0000000122). The work performed in Montreal was supported by the Canadian Institutes of Health Research (CIHR), the Fon…
View article: The Use of Positron-Emission Tomography–Magnetic Resonance Imaging to Improve the Local Staging of Disease in Myxofibrosarcoma: A Feasibility Study
The Use of Positron-Emission Tomography–Magnetic Resonance Imaging to Improve the Local Staging of Disease in Myxofibrosarcoma: A Feasibility Study Open
Background/Objectives: Myxofibrosarcomas (MFSs) are aggressive soft-tissue sarcomas (STSs) that often arise in the upper and lower limbs. MFSs are a highly infiltrative sarcoma subtype with a high positive margin rate and poor clinical out…
View article: Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia
Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia Open
Neuropsychiatric symptoms (NPS) are prevalent, emerge early, and are associated with poorer outcomes in Lewy body dementia (LBD). Research suggests NPS may reflect LBD-related dysfunction in distributed neuronal networks. This study invest…
View article: Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies
Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies Open
Background Little is known about the prognostic value of plasma biomarkers in mild cognitive impairment with Lewy bodies (MCI‐LB). Objectives To investigate the association of four plasma biomarkers with disease progression in MCI. Methods…
View article: Visual cortical activity in Charles Bonnet syndrome: testing the deafferentation hypothesis
Visual cortical activity in Charles Bonnet syndrome: testing the deafferentation hypothesis Open
Visual hallucinations in individuals following sight loss (Charles Bonnet syndrome; CBS) have been posited to arise because of spontaneous, compensatory, neural activity in the visual cortex following sensory input loss from the eyes—known…
View article: P-1738. Effectiveness of Clinical Pharmacist-Driven Antimicrobial Stewardship (ASP) in Bacteremic Patients in India
P-1738. Effectiveness of Clinical Pharmacist-Driven Antimicrobial Stewardship (ASP) in Bacteremic Patients in India Open
Background Antimicrobial resistance is a prevalent problem, especially in low-middle-income countries. Infectious disease physicians are a scarce commodity and are unable to fully shoulder the complete responsibility of antimicrobial stewa…
View article: Disrupted functional brain network associated with presence of hallucinations in Parkinson’s disease
Disrupted functional brain network associated with presence of hallucinations in Parkinson’s disease Open
Hallucinations negatively impact quality of life in Parkinson's disease, yet their neural mechanisms remain poorly understood, particularly in early disease stages. This study aimed to identify functional connectivity differences associate…
View article: Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies
Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies Open
Background Mild cognitive impairment with Lewy bodies (MCI-LB) may be identified prospectively based on the presence of cognitive impairment and several core clinical features (visual hallucinations, cognitive fluctuations, parkinsonism, a…
View article: Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson’s disease
Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson’s disease Open
Substantia nigra (SN) and locus coeruleus (LC) are two catecholaminergic, neuromelanin-rich nuclei that are affected in Parkinson’s disease (PD) and may show neuroimaging abnormalities before the onset of motor manifestations. The simultan…
View article: Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies
Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies Open
The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had n…
View article: Disrupted functional brain network associated with presence of hallucinations in Parkinson’s Disease
Disrupted functional brain network associated with presence of hallucinations in Parkinson’s Disease Open
Background Hallucinations negatively impact quality of life in Parkinson’s disease, yet their neural mechanisms remain poorly understood, particularly in early disease stages. This study aimed to identify functional connectivity difference…
View article: Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder
Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder Open
Background Synucleinopathies manifest as a spectrum of disorders that vary in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD) and dementia with Lewy bodies. Patterns of brain atrophy in iRBD are alr…
View article: Outcomes of Patients With Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease at 3 and 5 Years After Diagnosis
Outcomes of Patients With Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease at 3 and 5 Years After Diagnosis Open
These findings support that prospectively identified probable MCI-LB is a prodromal presentation of DLB and that disease-specific classifications of MCI may reliably identify different prodromal dementias.
View article: Hypothalamic involvement in multiple system atrophy: A structural MRI study
Hypothalamic involvement in multiple system atrophy: A structural MRI study Open
In-vivo structural hypothalamic involvement may be present in MSA. Reduced posterior hypothalamus volume, which includes the mammillary bodies and lateral hypothalamus, is associated with worse cognitive functioning. Larger studies on hypo…
View article: Identifying parkinsonism in mild cognitive impairment
Identifying parkinsonism in mild cognitive impairment Open
The five-item scale is effective to identify parkinsonism in MCI, but a lower threshold must be used in MCI compared with dementia.
View article: Developing a novel dual-injection FDG-PET imaging methodology to study the functional neuroanatomy of gait
Developing a novel dual-injection FDG-PET imaging methodology to study the functional neuroanatomy of gait Open
Gait is an excellent indicator of physical, emotional, and mental health. Previous studies have shown that gait impairments in ageing are common, but the neural basis of these impairments are unclear. Existing methodologies are suboptimal …
View article: Promises and Challenges of Blood Based Biomarkers of Alzheimer’s Disease and Neurodegeneration in Mild Cognitive Impairment: Importance of Non‐Alzheimer’s Aetiologies
Promises and Challenges of Blood Based Biomarkers of Alzheimer’s Disease and Neurodegeneration in Mild Cognitive Impairment: Importance of Non‐Alzheimer’s Aetiologies Open
Background Blood‐based biomarkers of Alzheimer’s disease (AD) may help to rule AD in, with particular promise at the mild cognitive impairment (MCI) stage when potential disease‐modifying treatments may be most effective. However, AD is no…
View article: White matter changes in the cholinergic system in Alzheimer’s disease and dementia with Lewy bodies
White matter changes in the cholinergic system in Alzheimer’s disease and dementia with Lewy bodies Open
Background The early degeneration of the cholinergic nucleus basalis of Meynert (NBM) and its cortical projections is a hallmark of both dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD). In addition to the NBM, the other major …
View article: Functional connectivity in Lewy body disease with visual hallucinations
Functional connectivity in Lewy body disease with visual hallucinations Open
Background and purpose Visual hallucinations are a common, potentially distressing experience of people with Lewy body disease (LBD). The underlying brain changes giving rise to visual hallucinations are not fully understood, although prev…
View article: Serial Nigrostriatal Dopaminergic Imaging in Mild Cognitive Impairment With Lewy Bodies, Alzheimer Disease, and Age-Matched Controls
Serial Nigrostriatal Dopaminergic Imaging in Mild Cognitive Impairment With Lewy Bodies, Alzheimer Disease, and Age-Matched Controls Open
This study provides Class II evidence that longitudinal declines in striatal uptake measured using 123[I]-FP-CIT SPECT are associated with MCI due to Lewy body disease but not MCI due to Alzheimer disease.
View article: Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies
Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies Open
Background Blood biomarkers of Alzheimer's disease (AD) may allow for the early detection of AD pathology in mild cognitive impairment (MCI) due to AD (MCI-AD) and as a co-pathology in MCI with Lewy bodies (MCI-LB). However not all cases o…