Explanipedia

Long-read genome sequencing and multi-omics in aging and neurodegeneration Open

Tanner Jensen, Yann Le Guen, Lia Talozzi, Sherry Yang, John E. Gorzynski , et al. · 2025

Structural variants (SVs) are a major source of genetic variation yet remain underexplored in healthy aging and neurodegenerative diseases. We performed nanopore long-read genome sequencing (lrGS) on 551 deeply-phenotyped individuals from …

Plasma phosphorylated tau 217 detects amyloid-β in Neuronal Synuclein Disease Open

Alena Smith, Sara A. Lorkiewicz, Burak Arslan, Laia Montoliu‐Gaya, Nicholas J. Ashton , et al. · 2025

Background Multiple proteinopathies commonly coexist in neurodegenerative diseases, therefore it is critical to understand plasma biomarker performance to detect proteinopathies in these complex diseases. While plasma biomarkers can accura…

Air pollution and depression symptoms in middle-aged and older adults in Los Angeles County Open

Nicole M. Gatto, Marian Ramzy, Cecília Rocha, Howard N. Hodis, Fred Lurmann , et al. · 2025

High inter-rater reliability in consensus diagnoses and overall assessment in the Asian Cohort for Alzheimer’s Disease Study Open

Yara Alkhodair, Ging‐Yuek Robin Hsiung, Boon Lead Tee, Pei‐Chuan Ho, Paul Yeung , et al. · 2025

Denoising 7T Structural MRI with Conditional Generative Diffusion Models Open

Yixin Wang, Binxu Li, Yihao Liang, Mackenzie Carlson, Phillip DiGiacomo , et al. · 2025

Purpose 7T MRI offers ultra-high resolution and improved sensitivity for iron deposition in neurodegenerative disorders, but commonly used acquisitions are long and hence challenging, especially for elderly subjects. Efficiently denoising …

Obstructive sleep apnoea and risk of dementia: a Danish population-based cohort study Open

Sigrid Bjerge Gribsholt, Erzsébet Horváth–Puhó, Holly Elser, Kristina Laugesen, Nils Skajaa , et al. · 2025

Background Obstructive sleep apnoea (OSA) is associated with adverse health outcomes. However, the association with dementia remains uncertain. Thus, we examined the association of OSA with all-cause dementia and Alzheimer’s disease. Metho…

Parkinson’s disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction Open

Edward N. Wilson, Jacob Umans, Michelle S. Swarovski, Paras S. Minhas, Jaime Mendiola , et al. · 2025

Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson’s disease Open

Byeongwook Lee, Christina B. Young, Weidong Cai, Rui Yuan, Sephira G. Ryman , et al. · 2025

Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort Open

Kyan Younes, Emily Johns, Christina B. Young, Gabriel Kennedy, Shubhabrata Mukherjee , et al. · 2025

INTRODUCTION Amyloid positron emission tomography (PET) is increasingly available for diagnosis of Alzheimer`s disease (AD); however, its practical implications in heterogenous cohorts are debated. METHODS Amyloid PET from 890 National Alz…

Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease Open

Vahan Aslanyan, Rowan Saloner, John Kornak, Adam M. Staffaroni, Saul Villeda , et al. · 2024

The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate ‘pro-aging’ or ‘pro-youthful’ effects on the mouse brain. The clinical relevance and combined effec…

Plasma Aβ<sub>42</sub>/Aβ<sub>40</sub> is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum Open

Alexandra N. Trelle, Christina B. Young, Hillary Vossler, Javier Ramos Benitez, Karly Alex Cody , et al. · 2024

INTRODUCTION The availability of amyloid beta (Aβ) targeting therapies for Alzheimer's disease (AD) is increasing the demand for scalable biomarkers that are sensitive to early cerebral Aβ accumulation. METHODS We evaluated fully‐automated…

18F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease Open

Joseph R. Winer, Hillary Vossler, Christina B. Young, Viktorija Smith, America Romero , et al. · 2024

Co-pathology is frequent in Lewy body disease, which includes clinical diagnoses of both Parkinson’s disease and dementia with Lewy bodies. Measuring concomitant pathology in vivo can improve clinical and research diagnoses and prediction …

X‐chromosome-wide association study for Alzheimer’s disease Open

Julie Le Borgne, Lissette Gomez, Sami Heikkinen, Najaf Amin, Shahzad Ahmad , et al. · 2024

VEGF and ICAM5 Levels in Alzheimer’s Disease and Cognitively Healthy Aging Open

Claire Delpirou Nouh, Olamide Abiose, Tony Wyss‐Coray, Victor W. Henderson, Sharon J. Sha , et al. · 2024

Background Vascular dysfunction, blood‐brain barrier (BBB) dysregulation, and neuroinflammation are thought to participate in Alzheimer`s disease (AD) pathogenesis, though the mechanism is poorly understood. Among pathways of interest, AD …

Effects of α‐synuclein pathology in Alzheimer’s disease and normal aging Open

Joseph R. Winer, Melanie J. Plastini, America Romero, Edward N. Wilson, Christina B. Young , et al. · 2024

Background α‐Synuclein is the hallmark pathology of Parkinson’s disease and dementia with Lewy bodies, described together as Lewy body disease (LBD). α‐Synuclein is also commonly observed in the context of Alzheimer’s disease (AD). Here we…

Asian Cohort for Alzheimer’s Disease (ACAD) Study on Genetic and Non‐Genetic Risk Factors for Alzheimer’s Disease among Asian Americans and Canadians Open

Weixin Wang, Pei‐Chuan Ho, Boon Lead Tee, Clara Li, Yian Gu , et al. · 2024

Background Asian Americans and Asian Canadians (ASACs) are the fastest growing minority group in the US and Canada. However, ASACs are under‐sampled in Alzheimer’s disease (AD) research. To address the need of culturally appropriate clinic…

Misperception of night‐to‐night sleep quality in Alzheimer’s and Lewy body disease Open

Anuenue Washburn, Joseph R. Winer, America Romero, Maya Yutsis, Victor W. Henderson , et al. · 2024

Background Objective sleep measures obtained from actigraphy (wrist‐worn accelerometry) reveal sleep disruption patterns and may serve as indicators of neurodegenerative disease. However, whether individuals’ subjective account of their sl…

Elevated tau in the piriform cortex in Alzheimer’s but not Parkinson’s disease using MR‐PET Open

Hossein Moein Taghavi, Mahta Karimpoor, Eric van Staalduinen, Samantha Leventis, Christina B. Young , et al. · 2024

Background Olfactory deficiency can be present in preclinical Alzheimer’s (AD) and Parkinson’s disease (PD), predicting their subsequent manifestation, including mild cognitive impairment (MCI). Analyzing key regions within the olfactory c…

Comparing the diagnostic performance of plasma pTau181 and pTau217 for the identification of Alzheimer’s disease co‐pathology in Lewy Body Disease Open

Alena Smith, Melani J. Plastini, Nicholas J. Ashton, Laia Montoliu‐Gaya, Edward N. Wilson , et al. · 2024

Background Lewy body disease (LBD) often co‐occurs with Alzheimer’s disease neuropathological change (ADNC), which can be detected using plasma pTau181 and pTau217. Few studies have investigated these biomarkers in LBD, nor have studies in…

Over‐Representation of Extremely Wealthy Neighborhood Social Exposomes for Brain Donors within Alzheimer’s Disease Research Center Brain Banks assessed by the Neighborhoods Study Open

Amy Kind, Barbara B. Bendlin, W. Ryan Powell, Amanda DeWitt, Yixuan Cheng , et al. · 2024

Background Adverse social exposome (indexed by national Area Deprivation Index [ADI] 80‐100 or ‘high ADI’) is linked to structural inequities and increased risk of Alzheimer’s disease neuropathology. Twenty percent of the US population res…

Evidence for a protective effect of hormone replacement therapy on Alzheimer’s disease neuropathological and clinical outcomes across cohorts Open

Jennifer L. Bruno, Jacob S. Shaw, Victor W. Henderson, S. M. Hadi Hosseini · 2024

Background More than 2/3 of Alzheimer’s Disease (AD) patients are women, which has led to increased interest in the neurophysiological impact of estrogen decline during menopause. While early evidence suggested that hormone replacement the…

Amyloid-β predominant Alzheimer’s disease neuropathologic change Open

Gábor G. Kovács, Yuriko Katsumata, Xian Wu, Khine Zin Aung, David W. Fardo , et al. · 2024

Different subsets of Alzheimer’s disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic…

Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR Open

Hossein Moein Taghavi, Mahta Karimpoor, Eric K. van Staalduinen, Christina B. Young, Marios Georgiadis , et al. · 2024

INTRODUCTION Olfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography‐magnetic resonance (PET‐MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison …

Parkinson’s disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction Open

Edward N. Wilson, Jacob Umans, Michelle S. Swarovski, Paras S. Minhas, Øivind Midttun , et al. · 2024

Myeloproliferative Neoplasms and Dementia Risk: A Population‐Based Cohort Study Open

Yuelian Sun, Katalin Veres, Hans Carl Hasselbalch, Henrik Frederiksen, Lene Sofie Granfeldt Østgård , et al. · 2024

Objectives To estimate dementia risk for persons diagnosed with Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), which serve as a human chronic inflammation model. Methods We identified 9895 individuals in Denmark newl…

Data-driven discovery of movement-linked heterogeneity in neurodegenerative diseases Open

Mark Endo, Favour Nerrise, Qingyu Zhao, Edith V. Sullivan, Li Fei-Fei , et al. · 2024

Age-associated proteins explain the role of medial temporal lobe networks in Alzheimer’s disease Open

Adam Turnbull, Yejin Kim, Kai Zhang, Xiaoqian Jiang, Zihuai He , et al. · 2024

Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation Open

Emily Johns, Hillary Vossler, Christina B. Young, Mackenzie Carlson, Joseph R. Winer , et al. · 2024

INTRODUCTION Amyloid positron emission tomography (PET) acquisition timing impacts quantification. METHODS In florbetaben (FBB) PET scans of 245 adults with and without cognitive impairment, we investigated the impact of post‐injection acq…

Plasma pTau181 Reveals a Pathological Signature that Predicts Cognitive Outcomes in Lewy Body Disease Open

Carla Abdelnour, Christina B. Young, Marian Shahid, Alena Smith, Edward N. Wilson , et al. · 2024

Objective To determine whether plasma phosphorylated‐Tau181 (pTau181) could be used as a diagnostic biomarker of concurrent Alzheimer's disease neuropathologic change (ADNC) or amyloidosis alone, as well as a prognostic, monitoring, and su…

Frozen Shoulder and the Risk of Parkinson’s Disease: A Danish Registry-Based Cohort Study Open

Nadia R Gadgaard, Katalin Veres, Victor W. Henderson, Alma B Pedersen · 2024

Patients with frozen shoulder had an increased PD risk compared with the general population, although the absolute risks were low. Frozen shoulder might sometimes represent early manifestations of PD. Detection bias probably cannot account…

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