Victoria Booth
YOU?
Author Swipe
View article: Accuracy Versus Predominance: Reassessing the Validity of the Quasi-Steady-State Approximation
Accuracy Versus Predominance: Reassessing the Validity of the Quasi-Steady-State Approximation Open
The application of the standard quasi-steady-state approximation to the Michaelis-Menten reaction mechanism is a textbook example of biochemical model reduction, derived using singular perturbation theory. However, determining the specific…
View article: Mechanisms for dysregulation of excitatory-inhibitory balance underlying allodynia in dorsal horn neural subcircuits
Mechanisms for dysregulation of excitatory-inhibitory balance underlying allodynia in dorsal horn neural subcircuits Open
Chronic pain is a wide-spread condition that is debilitating and expensive to manage, costing the United States alone around $600 billion in 2010. In a common symptom of chronic pain called allodynia, non-painful stimuli produce painful re…
View article: GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus
GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus Open
Along the ascending auditory pathway, there is a broad shift from temporal coding, which is common in the lower auditory brainstem, to rate coding, which predominates in auditory cortex. This temporal‐to‐rate transition is particularly pro…
View article: A predictive propensity measure to enter REM sleep
A predictive propensity measure to enter REM sleep Open
Introduction During sleep periods, most mammals alternate multiple times between rapid-eye-movement (REM) sleep and non-REM (NREM) sleep. A common theory proposes that these transitions are governed by an “hourglass-like” homeostatic need …
View article: Data-driven mathematical modeling of sleep consolidation in early childhood
Data-driven mathematical modeling of sleep consolidation in early childhood Open
Across early childhood development, sleep behavior transitions from a biphasic pattern (a daytime nap and nighttime sleep) to a monophasic pattern (only nighttime sleep). The transition to consolidated nighttime sleep, which occurs in most…
View article: Mechanisms for dysregulation of excitatory-inhibitory balance underlying allodynia in dorsal horn neural subcircuits
Mechanisms for dysregulation of excitatory-inhibitory balance underlying allodynia in dorsal horn neural subcircuits Open
Chronic pain is a wide-spread condition that is debilitating and expensive to manage, costing the United States alone around $600 billion in 2010. In a common type of chronic pain called allodynia, non-painful stimuli produce painful respo…
View article: Special issue on cholinergic signalling
Special issue on cholinergic signalling Open
Peer Reviewed
View article: Acetylcholine facilitates localized synaptic potentiation and location specific feature binding
Acetylcholine facilitates localized synaptic potentiation and location specific feature binding Open
Forebrain acetylcholine (ACh) signaling has been shown to drive attention and learning. Recent experimental evidence of spatially and temporally constrained cholinergic signaling has sparked interest to investigate how it facilitates stimu…
View article: Modeling homeostatic and circadian modulation of human pain sensitivity
Modeling homeostatic and circadian modulation of human pain sensitivity Open
Introduction Mathematical modeling has played a significant role in understanding how homeostatic sleep pressure and the circadian rhythm interact to influence sleep-wake behavior. Pain sensitivity is also affected by these processes, and …
View article: 0113 Data-Driven Mathematical Modeling of Sleep Consolidation in Early Childhood
0113 Data-Driven Mathematical Modeling of Sleep Consolidation in Early Childhood Open
Introduction During early childhood, sleep behavior transitions from a biphasic pattern (daytime nap and nighttime sleep) to a monophasic pattern (nighttime sleep only). The transition to consolidated sleep, occurring in most children betw…
View article: GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus
GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus Open
Along the ascending auditory pathway, there is a broad shift from temporal coding, which is common in the lower auditory brainstem, to rate coding, which predominates in auditory cortex. This temporal-to-rate transition is particularly pro…
View article: Heterogeneous mechanisms for synchronization of networks of resonant neurons under different E/I balance regimes
Heterogeneous mechanisms for synchronization of networks of resonant neurons under different E/I balance regimes Open
Rhythmic synchronization of neuronal firing patterns is a widely present phenomenon in the brain—one that seems to be essential for many cognitive processes. A variety of mechanisms contribute to generation and synchronization of network o…
View article: Patterns of synchronization in 2D networks of inhibitory neurons
Patterns of synchronization in 2D networks of inhibitory neurons Open
Neural firing in many inhibitory networks displays synchronous assembly or clustered firing, in which subsets of neurons fire synchronously, and these subsets may vary with different inputs to, or states of, the network. Most prior analyti…
View article: Modeling cortical synaptic effects of anesthesia and their cholinergic reversal
Modeling cortical synaptic effects of anesthesia and their cholinergic reversal Open
General anesthetics work through a variety of molecular mechanisms while resulting in the common end point of sedation and loss of consciousness. Generally, the administration of common anesthetics induces reduction in synaptic excitation …
View article: Binaural Processing Deficits Due to Synaptopathy and Myelin Defects
Binaural Processing Deficits Due to Synaptopathy and Myelin Defects Open
Hidden hearing loss (HHL) is a deficit in auditory perception and speech intelligibility that occurs despite normal audiometric thresholds and results from noise exposure, aging, or myelin defects. While mechanisms causing perceptual defic…
View article: Modeling Synaptic Effects of Anesthesia and its Cortical Cholinergic Reversal
Modeling Synaptic Effects of Anesthesia and its Cortical Cholinergic Reversal Open
General anesthetics work through a variety of molecular mechanisms while resulting in the common end point of sedation and loss of consciousness. Generally, the administration of common inhalation anesthetics induces decreases in synaptic …
View article: Modelling learning in <scp> <i>Caenorhabditis elegans</i> </scp> chemosensory and locomotive circuitry for T‐maze navigation
Modelling learning in <span> <i>Caenorhabditis elegans</i> </span> chemosensory and locomotive circuitry for T‐maze navigation Open
Recently, a new type of Caenorhabditis elegans associative learning was reported, where nematodes learn to reach a target arm in an empty T‐maze, after they have successfully located reward (food) in the same side arm of a similar, baited,…
View article: Bifurcations of sleep patterns due to homeostatic and circadian variation in a sleep-wake flip-flop model
Bifurcations of sleep patterns due to homeostatic and circadian variation in a sleep-wake flip-flop model Open
Differential equation-based physiological models of sleep-wake networks describe sleep-wake regulation by simulating the activity of wake- and sleep-promoting neuronal populations and the modulation of these populations by homeostatic and …
View article: Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation
Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation Open
Theta and gamma rhythms and their cross-frequency coupling play critical roles in perception, attention, learning, and memory. Available data suggest that forebrain acetylcholine (ACh) signaling promotes theta-gamma coupling, although the …
View article: Correction: Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects
Correction: Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects Open
[This corrects the article DOI: 10.1371/journal.pcbi.1008499.].
View article: Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness
Personalized sleep-wake patterns aligned with circadian rhythm relieve daytime sleepiness Open
Summary Shift workers and many other groups experience irregular sleep-wake patterns. This can induce excessive daytime sleepiness that decreases productivity and elevates the risk of accidents. However, the degree of daytime sleepiness is…
View article: Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects
Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects Open
Hidden hearing loss (HHL) is an auditory neuropathy characterized by normal hearing thresholds but reduced amplitudes of the sound-evoked auditory nerve compound action potential (CAP). In animal models, HHL can be caused by moderate noise…
View article: Contrasting mechanisms for hidden hearing loss: synaptopathy vs myelin defects
Contrasting mechanisms for hidden hearing loss: synaptopathy vs myelin defects Open
Hidden hearing loss (HHL) is an auditory neuropathy characterized by normal hearing thresholds but reduced amplitude of the sound-evoked auditory nerve compound action potential (CAP). It has been proposed that in humans HHL leads to speec…