Explanipedia

The Pediatric and Young Adult Choroidal and Ciliary Body Melanoma Genetic Study, A Survey by the European Ophthalmic Oncology Group Open

Natasha M. van Poppelen, Nathalie Cassoux, Joni A. Turunen, Nicole C. Naus, Robert M. Verdijk , et al. · 2024

We did not find a stronger-than-average BAP1 germline predisposition for choroidal and ciliary body melanoma among children and young adults compared to adults. Males had a more favorable survival and disomy 3, and the absence of a BAP1 mu…

Qualitative assessment of the risk of SARS-CoV-2 to human health through food exposures to deer in the UK Open

Erica Kintz, Erin D. Lewis, Victoria M.L. Cohen · 2023

SARS-CoV-2, the coronavirus responsible for the infectious disease COVID-19 (Gorbalenya et al 2020 (Opens in a new window)), was first detected in the human population in December 2019 (Zhu et al 2020 (Opens in a new window)). It has since…

Correlation between BAP1 Localization, Driver Mutations, and Patient Survival in Uveal Melanoma Open

Yasemin Cole, Yu Zhi Zhang, Beatrice Gallo, Adam Januszewski, Anca Năstase , et al. · 2022

Uveal melanoma (UM) is an uncommon but highly aggressive ocular malignancy. Poor overall survival is associated with deleterious BAP1 alterations, which frequently occur with monosomy 3 (LOH3) and a characteristic gene expression profile. …

Proton beam radiotherapy for choroidal and ciliary body melanoma in the UK—national audit of referral patterns of 1084 cases Open

Rumana Hussain, A. Chiu, Bradley Pittam, Azzam Taktak, Bertil Damato , et al. · 2022

A Phase 1 study of <span>ADI‐PEG20</span> (pegargiminase) combined with cisplatin and pemetrexed in <span>ASS1‐negative</span> metastatic uveal melanoma Open

Pui Ying Chan, Melissa Phillips, Stephen Ellis, Amanda Johnston, Xiaoxing Feng , et al. · 2022

Metastatic uveal melanoma (UM) is a devastating disease with few treatment options. We evaluated the safety, tolerability and preliminary activity of arginine depletion using pegylated arginine deiminase ( ADI‐PEG20; pegargiminase) combine…

Long-term visual outcomes after ruthenium plaque brachytherapy for posterior choroidal melanoma Open

Roderick O’Day, Kelsey A. Roelofs, Guy S. Negretti, Gordon Hay, Anmol Arora , et al. · 2022

Consenso sobre el tratamiento del síndrome inflamatorio multisistémico asociado a COVID-19 Open

Dra Gabriela, Dra Ensinck, Dra Gregorio, Dra Rosana, María Flores , et al. · 2021

The pandemic caused by the SARS-CoV-2 virus declared by the WHO in March 11th 2020, affects a small number of pediatric patients, who mostly present mild respiratory compromise and favorable evolution. However began to be observed in previ…

Impact of COVID-19 pandemic on eye cancer care in United Kingdom Open

Haoyu Wang, Mohamed Elsheikh, Kenneth Gilmour, Victoria M.L. Cohen, Mandeep S. Sagoo , et al. · 2021

Distinguishing Choroidal Nevi from Melanomas Using the MOLES Algorithm: Evaluation in an Ocular Nevus Clinic Open

Lamis Al Harby, Mandeep S. Sagoo, Roderick O’Day, Gordon Hay, Anmol Arora , et al. · 2021

Objective: The aim of this study was to determine the sensitivity and specificity of the MOLES scoring system in differentiating choroidal melanomas from nevi according to Mushroom shape, Orange pigment, Large tumor size, Enl…

The natural history of conjunctival naevi in children and adolescents Open

Guy S. Negretti, Kelsey A. Roelofs, Bertil Damato, Mandeep S. Sagoo, Sahar Parvizi , et al. · 2020

Prospective validation of a virtual clinic pathway in the management of choroidal naevi: the NAEVUS study Report no. 1: safety assessment Open

Lamis Al Harby, Zaria Ali, Azita Rajai, Stephen A. Roberts, Tünde Pető , et al. · 2020

Background Choroidal naevi are a common incidental finding prompting specialist referrals to ocular oncology. Rarely, such lesions have sufficient suspicious features to diagnose a small melanoma. The aim of the study is to show that ‘virt…

Detecting Progression of Melanocytic Choroidal Tumors by Sequential Imaging: Is Ultrasonography Necessary? Open

Kelsey A. Roelofs, Roderick O’Day, Lamis Al Harby, Gordon Hay, Anmol Arora , et al. · 2020

Purpose: To determine if ultrasonography is necessary to detect progression of choroidal melanocytic tumors undergoing sequential multi-modal imaging with color photography, autofluorescence (AF) and optical coherence tomography (OCT). Met…

Circumscribed choroidal haemangioma: Indocyanine green angiography features on scanning laser ophthalmoscopy versus traditional digital fundus photography Open

Kelsey A. Roelofs, David Sia, Roderick O’Day, Gordon Hay, Anmol Arora , et al. · 2020

The MOLES System for Planning Management of Melanocytic Choroidal Tumors: Is It Safe? Open

Kelsey A. Roelofs, Roderick O’Day, Lamis Al Harby, Anmol Arora, Victoria M.L. Cohen , et al. · 2020

Purpose: To evaluate the MOLES system for identifying malignancy in melanocytic choroidal tumors in patients treated for choroidal melanoma. Methods: Records of 615 patients treated for choroidal melanoma between January 2017 and December …

Ultra-wide-field imaging assessment of small choroidal pigmented lesions using red and green colour channels Open

Vasilios P. Papastefanou, Rana’a T. Al‐Jamal, Zaria Ali, Victoria M.L. Cohen, Jane Gray , et al. · 2020

Iris extramedullary hematopoiesis in choroidal melanoma Open

Beatrice Gallo, Rana’a T. Al‐Jamal, Caroline Thaung, Victoria M.L. Cohen · 2020

PURPOSE: Extramedullary hematopoiesis (EMH) usually occurs in patients with loss of bone marrow hematopoietic function, and in a vast majority of cases, it involves the liver, the spleen, or the lymph nodes. We report EMH in the iris of pa…

Conjunctival Melanoma with Ipsilateral, Non-Contiguous Eyelid Involvement: A Case Report and Comprehensive Review of the Literature Open

Kelsey A. Roelofs, Grigorios Mitsopoulos, Victoria M.L. Cohen · 2020

While the majority of cases of conjunctival melanoma (CM) involve the bulbar conjunctiva, concurrent pigmentation of the ipsilateral eyelid can be seen in up to 15% of cases. Although extension of conjunctival melanoma into the eyelid (AJC…

Management Issues in Conjunctival Tumours: Ocular Surface Squamous Neoplasia Open

Victoria M.L. Cohen, Roderick O’Day · 2019

Ocular surface squamous neoplasia is the most common tumour of the ocular surface. It is a spectrum of disease from intraepithelial dysplasia to invasive squamous cell carcinoma. Recent years have seen an increase in the use of topical che…

Management Issues in Conjunctival Tumours: Conjunctival Melanoma and Primary Acquired Melanosis Open

Victoria M.L. Cohen, Roderick O’Day · 2019

Response to “Two Uveal Melanomas in One Eye: A Choroidal Nevus Giving Rise to a Melanoma in an Eye with a Separate Large Choroidal Melanoma” Open

Ido Didi Fabian, Victoria M.L. Cohen · 2019

Dear Editor,We read with interest the manuscript by Prager et al. [1], who reported a case of multifocal uveal melanoma in the same eye. These cases, as the authors indicate in their paper, are rare – only about 20 have been reported to da…

Staging uveal melanoma with whole-body positron-emission tomography/computed tomography and abdominal ultrasound: Low incidence of metastatic disease, high incidence of second primary cancers Open

Victoria M.L. Cohen, Efthymia Pavlidou, Joanna DaCosta, Anmol Arora, Teressa Szyszko , et al. · 2018

Whole-body PET/CT and abdominal ultrasound complement each other in the staging of uveal melanoma. Benign hepatic abnormalities found using ultrasound is common. Of importance, a second asymptomatic primary malignancy associated with uveal…

Choroidal metastasis presenting with tumour surface orange lipofuscin pigment Open

Amer N Masalha, Ido Didi Fabian, Victoria M.L. Cohen, Mandeep S. Sagoo · 2018

Background and Objective: In ocular oncology, orange-color lipofuscin is commonly associated with choroidal melanoma. We herein report a case series of choroidal metastases with overlying lipofuscin pigment. Methods: A retrospective case s…

Bilobed Iris Stromal Epithelial Cyst Open

Vasilios P. Papastefanou, Victoria M.L. Cohen · 2017

Primary photodynamic therapy with verteporfin for small pigmented posterior pole choroidal melanoma Open

Ido Didi Fabian, Andrew W. Stacey, Vasilios P. Papastefanou, Lamis Al Harby, Anmol Arora , et al. · 2017

Subretinal Hemorrhage Associated with Astrocytic Hamartoma Open

Anmol Arora, Ido Didi Fabian, Victoria M.L. Cohen · 2017

Visual Loss from Choroidal Melanoma Mimicking Neurological Syndromes Open

Karim Hammamji, Ehud Reich, Anmol Arora, Victoria M.L. Cohen, Mandeep S. Sagoo · 2017

Melanoma of the eye is rare, but can mimic a range of disorders. This report highlights 2 cases of choroidal melanoma with vision loss mimicking neurological diagnoses. The first patient is a 41-year-old white male with a known history of …

Ocular oncology: advances in retinoblastoma, uveal melanoma and conjunctival melanoma Open

Marina Vasalaki, Ido Didi Fabian, M. Ashwin Reddy, Victoria M.L. Cohen, Mandeep S. Sagoo · 2017

Improvements in chemotherapy delivery in retinoblastoma and prognostic tests in melanomas.

Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma Open

Kalijn F. Bol, Thomas van den Bosch, Gerty Schreibelt, Hanneke W. Mensink, J. E. E. Keunen , et al. · 2016

Intravitreal bevacizumab monotherapy for choroidal neovascularisation secondary to choroidal osteoma Open

Vasilios P. Papastefanou, Maria Pefkianaki, Lamis Al Harby, Anmol Arora, Victoria M.L. Cohen , et al. · 2016

The Pediatric Choroidal and Ciliary Body Melanoma Study Open

Rana’a T. Al‐Jamal, Nathalie Cassoux, Laurence Desjardins, Bertil Damato, Lazaros Konstantinidis , et al. · 2016

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