Victoria H. Meller
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View article: Abstract 2465 Characterizing Small RNA from Satellite Repeats on the Drosophila melanogaster X Chromosome
Abstract 2465 Characterizing Small RNA from Satellite Repeats on the Drosophila melanogaster X Chromosome Open
View article: When Down Is Up: Heterochromatin, Nuclear Organization and X Upregulation
When Down Is Up: Heterochromatin, Nuclear Organization and X Upregulation Open
Organisms with highly differentiated sex chromosomes face an imbalance in X-linked gene dosage. Male Drosophila solve this problem by increasing expression from virtually every gene on their single X chromosome, a process known as dosage c…
View article: Developmental regulation of calmodulin-dependent adenylate cyclase activity in an insect endocrine gland.
Developmental regulation of calmodulin-dependent adenylate cyclase activity in an insect endocrine gland. Open
The insect prothoracic gland produces ecdysteroids that elicit molting and metamorphosis, and neurohormone stimulation of steroidogenesis by this gland involves both Ca2+ and cyclic adenosine monophosphate second messengers. Prothoracic gl…
View article: Chromatin That Guides Dosage Compensation Is Modulated by the siRNA Pathway in <i>Drosophila melanogaster</i>
Chromatin That Guides Dosage Compensation Is Modulated by the siRNA Pathway in <i>Drosophila melanogaster</i> Open
A family of X-linked repetitive elements enhances dosage compensation of nearby genes in male flies. Here, Deshpande and Meller show that chromatin around these repeats is modified in a siRNA-dependent manner. Proteins that interact with t…
View article: Chromatin at X-linked repeats that guide dosage compensation in<i>Drosophila melanogaster</i>is modulated by the siRNA pathway
Chromatin at X-linked repeats that guide dosage compensation in<i>Drosophila melanogaster</i>is modulated by the siRNA pathway Open
Many heterogametic organisms adjust sex chromosome expression to accommodate differences in gene dosage. This requires selective recruitment of regulatory factors to the modulated chromosome. How these factors are localized to a chromosome…
View article: Satellite Repeats Identify X Chromatin for Dosage Compensation in Drosophila melanogaster Males
Satellite Repeats Identify X Chromatin for Dosage Compensation in Drosophila melanogaster Males Open
View article: Host–Symbiont Interactions: Male-Killers Exposed
Host–Symbiont Interactions: Male-Killers Exposed Open
View article: Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males
Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males Open
The ribonucleoprotein Male Specific Lethal (MSL) complex is required for X chromosome dosage compensation in Drosophila melanogaster males. Beginning at 3 h of development the MSL complex binds transcribed X-linked genes and modifies chrom…
View article: Identification of the Drosophila X chromosome: The long and short of it
Identification of the Drosophila X chromosome: The long and short of it Open
The different dose of X chromosomes in males and females produces a potentially fatal imbalance in X-linked gene products. This imbalance is addressed by dosage compensation, a process that modulates expression from an entire X chromosome …
View article: Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors
Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors Open
The eukaryotic genome is assembled into distinct types of chromatin. Gene-rich euchromatin has active chromatin marks, while heterochromatin is gene-poor and enriched for silencing marks. In spite of this, genes native to heterochromatic r…