Vijay Patel
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View article: Use of Artificial Intelligence in Triage in Hospital Emergency Departments: A Scoping Review
Use of Artificial Intelligence in Triage in Hospital Emergency Departments: A Scoping Review Open
View article: Acute exertional compartment syndrome of the supraspinatus
Acute exertional compartment syndrome of the supraspinatus Open
Acute exertional compartment syndrome (AECS) is increasingly recognised as an emergency presentation requiring urgent surgical intervention. This can theoretically affect any myofascial compartment, but is rare around the shoulder, with ve…
View article: Translational link between gene expression in human subcutaneous adipose tissue and cardiac function
Translational link between gene expression in human subcutaneous adipose tissue and cardiac function Open
View article: <p>From Vulnerability to Resilience: The Impact of Global Shocks on Recovery Pathways in Tourism-Dependent Economies</p><p>&nbsp;</p>
From Vulnerability to Resilience: The Impact of Global Shocks on Recovery Pathways in Tourism-Dependent Economies Open
View article: Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation
Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation Open
The ongoing obesity epidemic has raised awareness of the complex physiology of adipose tissue. Abnormal adipocyte differentiation results in the development of systemic metabolic disorders such as insulin resistance and diabetes. The conju…
View article: Use of Artificial Intelligence in Triage in Hospital Emergency Departments: A Scoping Review
Use of Artificial Intelligence in Triage in Hospital Emergency Departments: A Scoping Review Open
View article: AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice
AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice Open
AGPAT3 deficiency results in male-specific growth retardation. It reduces adipose tissue mass but does not significantly impact glucose homeostasis or energy balance, except for influencing water intake in mice. Like AGPAT2, AGPAT3 is upre…
View article: A Retrospective Analysis of AngioVac Outcomes at a Tertiary Care Center
A Retrospective Analysis of AngioVac Outcomes at a Tertiary Care Center Open
View article: Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology
Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology Open
A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such, provides a semi-selective barrier between the blood and the interstitial space. Compromise of the lung EC barrier due to inflammatory or toxic events may…
View article: Lenvatinib Plus Pembrolizumab Versus Sunitinib in First-Line Treatment of Advanced Renal Cell Carcinoma: Final Prespecified Overall Survival Analysis of CLEAR, a Phase III Study
Lenvatinib Plus Pembrolizumab Versus Sunitinib in First-Line Treatment of Advanced Renal Cell Carcinoma: Final Prespecified Overall Survival Analysis of CLEAR, a Phase III Study Open
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. …
View article: Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology
Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology Open
A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and as such provides a semi-selective barrier between the blood and the interstitial space. Compromise of the lung EC barrier due to inflammatory or toxic events may r…
View article: Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease
Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease Open
Introduction Human saphenous veins (SV) are widely used as grafts in coronary artery bypass (CABG) surgery but often fail due to neointima proliferation (NP). NP involves complex interplay between vascular smooth muscle cells (VSMC) and fi…
View article: P11.54.A BRAIN RELAPSE IN HER2-POSITIVE BREAST CANCER AFTER NEOADJUVANT TREATMENT: AN INTERNATIONAL MULTICENTRIC STUDY
P11.54.A BRAIN RELAPSE IN HER2-POSITIVE BREAST CANCER AFTER NEOADJUVANT TREATMENT: AN INTERNATIONAL MULTICENTRIC STUDY Open
BACKGROUND The incidence of central nervous system relapse among patients with breast cancer appears to be increasing, despite advances in systemic treatment. Although achieving pathological complete response (pCR) following neoadjuvant tr…
View article: Type 1 Diabetes Impairs Endothelium-Dependent Relaxation Via Increasing Endothelial Cell Glycolysis Through Advanced Glycation End Products, PFKFB3, and Nox1-Mediated Mechanisms
Type 1 Diabetes Impairs Endothelium-Dependent Relaxation Via Increasing Endothelial Cell Glycolysis Through Advanced Glycation End Products, PFKFB3, and Nox1-Mediated Mechanisms Open
BACKGROUND: Type 1 diabetes (T1D) is a major cause of endothelial dysfunction. Although cellular bioenergetics has been identified as a new regulator of vascular function, whether glycolysis, the primary bioenergetic pathway in endothelial…
View article: A service evaluation of the newly introduced sciatic nerve local anaesthetic infusion catheters for acute pain management of major lower limb amputations
A service evaluation of the newly introduced sciatic nerve local anaesthetic infusion catheters for acute pain management of major lower limb amputations Open
Background: Patients who undergo lower limb amputations experience severe acute postoperative pain. Despite having no strong evidence for the efficacy of peripheral nerve blocks in reducing phantom limb pain, the reduction in acute postope…
View article: Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
View article: Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
View article: Data from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Data from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Purpose:Glutaminase is a key enzyme, which supports elevated dependency of tumors on glutamine-dependent biosynthesis of metabolic intermediates. Dual targeting of glucose and glutamine metabolism by the mTOR inhibitor everolimus plus the …
View article: Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
View article: Supplementary Table from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Supplementary Table from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Supplementary Table from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
View article: Supplementary Table from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Supplementary Table from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Supplementary Table from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
View article: Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Supplementary Figure from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
View article: Data from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Data from Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Purpose:Glutaminase is a key enzyme, which supports elevated dependency of tumors on glutamine-dependent biosynthesis of metabolic intermediates. Dual targeting of glucose and glutamine metabolism by the mTOR inhibitor everolimus plus the …
View article: Successful Cesarean Section in a COVID-19 Patient on Extracorporeal Membrane Oxygenation (ECMO)
Successful Cesarean Section in a COVID-19 Patient on Extracorporeal Membrane Oxygenation (ECMO) Open
The pandemic of COVID-19-related respiratory failure has increased utilization of ECMO in diverse patient populations. There are limited published reports of ECMO use in pregnancy, and reports of successful delivery of the fetus with survi…
View article: Growth productivity as a determinant of the inoculum effect for bactericidal antibiotics
Growth productivity as a determinant of the inoculum effect for bactericidal antibiotics Open
Understanding the mechanisms by which populations of bacteria resist antibiotics has implications in evolution, microbial ecology, and public health. The inoculum effect (IE), where antibiotic efficacy declines as the density of a bacteria…
View article: Endocarditis with No Valve Involvement? A Case of Superior Vena Cava Endocarditis, Rare but Serious Vascular Infection
Endocarditis with No Valve Involvement? A Case of Superior Vena Cava Endocarditis, Rare but Serious Vascular Infection Open
Patients with end-stage renal disease (ESRD) will likely need vascular access for hemodialysis, the vascular access increases the risk of having bloodstream infections such as Catheter-Related Bloodstream Infections (CRBSI). Rarely some pa…
View article: Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial Open
Purpose: Glutaminase is a key enzyme, which supports elevated dependency of tumors on glutamine-dependent biosynthesis of metabolic intermediates. Dual targeting of glucose and glutamine metabolism by the mTOR inhibitor everolimus plus the…
View article: A Lost Bullet in the Coronary Sinus: A Cautionary Tale
A Lost Bullet in the Coronary Sinus: A Cautionary Tale Open
We present a case of venous bullet embolism to the right atrium following a gunshot wound (GSW) to the abdomen. A 53-year-old male presented after a GSW to the abdomen. His workup included a computed tomography (CT) scan demonstrating an a…
View article: SUCCESSFUL UTILIZATION OF EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) IN A PREGNANT WOMAN WITH COVID-19 ASSOCIATED ACUTE RESPIRATORY DISTRESS SYNDROME
SUCCESSFUL UTILIZATION OF EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) IN A PREGNANT WOMAN WITH COVID-19 ASSOCIATED ACUTE RESPIRATORY DISTRESS SYNDROME Open
View article: Role of Caveolae in the Development of Microvascular Dysfunction and Hyperglycemia in Type 2 Diabetes
Role of Caveolae in the Development of Microvascular Dysfunction and Hyperglycemia in Type 2 Diabetes Open
In type 2 diabetes (T2D) microvascular dysfunction can interfere with tissue glucose uptake thereby contributing to the development of hyperglycemia. The cell membrane caveolae orchestrate signaling pathways that include microvascular cont…