Vidya P. Kumar
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View article: FSL-1 Pre-Administration Protects Radiation-Induced Hematopoietic Organs Through the Modulation of the TLR Signaling Pathway
FSL-1 Pre-Administration Protects Radiation-Induced Hematopoietic Organs Through the Modulation of the TLR Signaling Pathway Open
Substantial progress has been made in the development of radiation countermeasures, resulting in the recent approval of several mitigators; however, there has yet to be an approved prophylactic radioprotectant. Research on countermeasure p…
View article: Delayed Impact of Ionizing Radiation Depends on Sex: Integrative Metagenomics and Metabolomics Analysis of Rodent Colon Content
Delayed Impact of Ionizing Radiation Depends on Sex: Integrative Metagenomics and Metabolomics Analysis of Rodent Colon Content Open
There is an escalating need to comprehend the long-term impacts of nuclear radiation exposure since the permeation of ionizing radiation has been frequent in our current societal framework. A system evaluation of the microbes that reside i…
View article: Exploring Angiotensin II and Oxidative Stress in Radiation-Induced Cataract Formation: Potential for Therapeutic Intervention
Exploring Angiotensin II and Oxidative Stress in Radiation-Induced Cataract Formation: Potential for Therapeutic Intervention Open
Radiation-induced cataracts (RICs) represent a significant public health challenge, particularly impacting individuals exposed to ionizing radiation (IR) through medical treatments, occupational settings, and environmental factors. Effecti…
View article: Ionizing Radiation Dose Differentially Affects the Host–Microbe Relationship over Time
Ionizing Radiation Dose Differentially Affects the Host–Microbe Relationship over Time Open
Microorganisms that colonize in or on a host play significant roles in regulating the host’s immunological fitness and bioenergy production, thus controlling the host’s stress responses. Radiation elicits a pro-inflammatory and bioenergy-e…
View article: Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention
Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention Open
Medical procedures, such as radiation therapy, are a vital element in treating many cancers, significantly contributing to improved survival rates. However, a common long-term complication of such exposure is radiation-induced skin fibrosi…
View article: Innovations in Recovery Programs in Maternal and Neonatal Health: Experiences from a Hospital Network
Innovations in Recovery Programs in Maternal and Neonatal Health: Experiences from a Hospital Network Open
Background: The delivery of high-quality maternal and neonatal care is challenging in low- and middle-income countries. This study assesses a program aimed at offering evidence-informed care and enhancing service utilization. Methods: Data…
View article: Time- and sex-dependent delayed effects of acute radiation exposure manifest via miRNA dysregulation
Time- and sex-dependent delayed effects of acute radiation exposure manifest via miRNA dysregulation Open
The detrimental effects of high-dose ionizing radiation on human health are well-known, but the influence of sex differences on the delayed effects of acute radiation exposure (DEARE) remains unclear. Here, we conducted six-month animal ex…
View article: The Roles of IL-18 in a Realistic Partial Body Irradiation with 5% Bone Marrow Sparing (PBI/BM5) Model
The Roles of IL-18 in a Realistic Partial Body Irradiation with 5% Bone Marrow Sparing (PBI/BM5) Model Open
IL-18 has been shown to play important roles in response to total body irradiation. However, homogenous total body irradiation is not a realistic model to reflect the radiation exposure in a real nuclear event. To further study the roles o…
View article: PrC-210 Protects against Radiation-Induced Hematopoietic and Intestinal Injury in Mice and Reduces Oxidative Stress
PrC-210 Protects against Radiation-Induced Hematopoietic and Intestinal Injury in Mice and Reduces Oxidative Stress Open
The development of safe, orally available, and effective prophylactic countermeasures to protect our warfighters is an unmet need because there is no such FDA-approved countermeasure available for use. Th 1-Propanethiol, 3-(methylamino)-2-…
View article: CDX-301 prevents radiation-induced dysregulation of miRNA expression and biogenesis
CDX-301 prevents radiation-induced dysregulation of miRNA expression and biogenesis Open
Risks of radiation exposure necessitate the development of radioprophylactic drugs. We have reported the efficacy of CDX-301, a recombinantly developed human protein form of Fms-related tyrosine kinase 3 ligand (Flt3L), as a radioprophylac…
View article: Pre-Administration of PLX-R18 Cells Protects Mice from Radiation-Induced Hematopoietic Failure and Lethality
Pre-Administration of PLX-R18 Cells Protects Mice from Radiation-Induced Hematopoietic Failure and Lethality Open
Acute Radiation Syndrome (ARS) is a syndrome involving damage to multiple organs caused by exposure to a high dose of ionizing radiation over a short period of time; even low doses of radiation damage the radiosensitive hematopoietic syste…
View article: Mitigation of Total Body Irradiation-Induced Mortality and Hematopoietic Injury of Mice by a Thrombopoietin Mimetic (JNJ-26366821)
Mitigation of Total Body Irradiation-Induced Mortality and Hematopoietic Injury of Mice by a Thrombopoietin Mimetic (JNJ-26366821) Open
The threat of a nuclear attack has increased in recent years highlighting the benefit of developing additional therapies for the treatment of victims suffering from Acute Radiation Syndrome (ARS). In this work, we evaluated the impact of a…
View article: Corrigendum: Gamma Tocotrienol Protects Mice From Targeted Thoracic Radiation Injury
Corrigendum: Gamma Tocotrienol Protects Mice From Targeted Thoracic Radiation Injury Open
[This corrects the article DOI: 10.3389/fphar.2020.587970.].
View article: Gamma Tocotrienol Protects Mice From Targeted Thoracic Radiation Injury
Gamma Tocotrienol Protects Mice From Targeted Thoracic Radiation Injury Open
Radiation injury will result in multiorgan dysfuntion leading to multiorgan failure. In addition to many factors such as radiation dose, dose rate, the severity of the injury will also depend on organ systems which are exposed. Here, we re…
View article: Mitochondrial Degeneration and Autophagy Associated With Delayed Effects of Radiation in the Mouse Brain
Mitochondrial Degeneration and Autophagy Associated With Delayed Effects of Radiation in the Mouse Brain Open
Mitochondria are linked with various radiation responses, including mitophagy, genomic instability, apoptosis, and the bystander effect. Mitochondria play an important role in preserving cellular homeostasis during stress responses, and dy…
View article: Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin
Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin Open
Ionizing radiation exposure is a major concern for active military service members, as well as civilian population. Considering that the exposure is not predictable, it is imperative that strategies to counteract radiation damage must be d…
View article: Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol
Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol Open
Gamma-tocotrienol (GT3), a naturally occurring vitamin E isomer, a promising radioprotector, has been shown to protect mice against radiation-induced hematopoietic and gastrointestinal injuries. We analyzed changes in protein expression pr…
View article: Impact of Abbreviated Filgrastim Schedule on Survival and Hematopoietic Recovery after Irradiation in Four Mouse Strains with Different Radiosensitivity
Impact of Abbreviated Filgrastim Schedule on Survival and Hematopoietic Recovery after Irradiation in Four Mouse Strains with Different Radiosensitivity Open
Filgrastim (Neupogen®, granulocyte-colony stimulating factor) is among the few countermeasures recommended for management of patients in the event of lethal total-body irradiation. Despite the plethora of studies using filgrastim as a radi…
View article: Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection
Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection Open
The purpose of this study was two-fold: (1) to formulate γ-tocotrienol (GT3) in a nanoemulsion formulation as a prophylactic orally administered radioprotective agent; and (2) to optimize the storage conditions to preserve the structural i…
View article: Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Open
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is…
View article: Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone
Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone Open
Human babesiosis is a tick-borne multisystem disease caused by Babesia species of the apicomplexan phylum. Most clinical cases and fatalities of babesiosis are caused by Babesia microti. Current treatment for human babesiosis consists of t…
View article: Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen
Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen Open
Ionizing radiation causes depletion of hematopoietic cells and enhances the risk of developing secondary hematopoietic malignancies. Vitamin E analog gamma-tocotrienol (GT3), which has anticancer properties, promotes postirradiation hemato…
View article: Open source drug discovery with the malaria box compound collection for neglected diseases and beyond
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond Open
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is…