Vidya Mangala Prasad
YOU?
Author Swipe
View article: Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients
Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients Open
MAPT/tau proteins propagate between brain regions in a prion-like manner, driving the onset and progression of dementia in Alzheimer disease (AD). However, the basis for variability in dementia progression among AD patients remains poorly …
View article: Next-gen novel nanocage-based multivalent vaccine candidate to tackle the rising menace of Mpox
Next-gen novel nanocage-based multivalent vaccine candidate to tackle the rising menace of Mpox Open
View article: Endophilin mediated endocytosis and Epidermal growth factor receptor govern Japanese encephalitis virus entry and infection in neuronal cells
Endophilin mediated endocytosis and Epidermal growth factor receptor govern Japanese encephalitis virus entry and infection in neuronal cells Open
Several trafficking pathways are operational at the plasma membrane, and both clathrin-dependent, and clathrin-independent endocytosis (CIE), can serve as virus entry portals. Our research has shown that the neurotropic flavivirus: Japanes…
View article: <scp>tPA</scp>‐<scp>GFP</scp> is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells
<span>tPA</span>‐<span>GFP</span> is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells Open
Pancreatic β‐cells secrete insulin stored in large dense core vesicles (LDCV) by fusion of vesicle and plasma membrane during a process called insulin exocytosis. Insulin secretion is biphasic with a fast first phase and a sustained second…
View article: Comparison of localization and release of multivesicular bodies and secretory granules in islet cells: Dysregulation during type‐2 diabetes
Comparison of localization and release of multivesicular bodies and secretory granules in islet cells: Dysregulation during type‐2 diabetes Open
Multivesicular bodies (MVBs) are vesicles of endosomal origin containing intraluminal vesicles, which upon fusion with plasma membrane, secrete exosomes. They play a significant role in the physiology and pathology of type‐2 diabetes (T2D)…
View article: mRNA-based VP8* nanoparticle vaccines against rotavirus are highly immunogenic in rodents
mRNA-based VP8* nanoparticle vaccines against rotavirus are highly immunogenic in rodents Open
View article: An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting
An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting Open
View article: Advances in computational approaches to structure determination of alphaviruses and flaviviruses using cryo-electron microscopy
Advances in computational approaches to structure determination of alphaviruses and flaviviruses using cryo-electron microscopy Open
View article: An HIV-1 Broadly Neutralizing Antibody Overcomes Structural and Dynamic Variation through Highly Focused Epitope Targeting
An HIV-1 Broadly Neutralizing Antibody Overcomes Structural and Dynamic Variation through Highly Focused Epitope Targeting Open
The existence of broadly cross-reactive antibodies that can neutralize diverse HIV-1 isolates (bnAbs) has been appreciated for more than a decade. Many high-resolution structures of bnAbs, typically with one or two well-characterized HIV-1…
View article: Novel mRNA-based VP8* vaccines against rotavirus are highly immunogenic in rodents
Novel mRNA-based VP8* vaccines against rotavirus are highly immunogenic in rodents Open
Despite the availability of live-attenuated oral vaccines, rotavirus remains a major cause of severe childhood diarrhea worldwide. Due to the growing demand for parenteral rotavirus vaccines, we developed novel mRNA-based vaccine candidate…
View article: Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery
Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery Open
View article: Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery
Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery Open
Chikungunya virus (CHIKV) is a human pathogen that delivers its genome to the host cell cytoplasm through endocytic low pH-activated membrane fusion mediated by class-II fusion proteins. Though structures of prefusion, icosahedral CHIKV ar…
View article: Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery
Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery Open
Chikungunya virus (CHIKV) is a human pathogen that delivers its genome to the host cell cytoplasm through endocytic low pH-activated membrane fusion mediated by class-II fusion proteins. Though structures of prefusion, icosahedral CHIKV ar…
View article: Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice
Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice Open
HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion context has eluded detailed characterization. Here, we used cryo-electron tomog…
View article: Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization
Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization Open
Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at eliciting cross-reactive neutralizing antibodie…
View article: Cryo-ET of HIV reveals Env positioning on Gag lattice and structural variation among Env trimers
Cryo-ET of HIV reveals Env positioning on Gag lattice and structural variation among Env trimers Open
Summary HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion context has eluded detailed characterization. Here we used cryo-electro…
View article: Tracking structural intermediates during Chikungunya virus membrane fusion using cryo-electron tomography and sub-tomogram averaging
Tracking structural intermediates during Chikungunya virus membrane fusion using cryo-electron tomography and sub-tomogram averaging Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection
Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection Open
Stimulating broadly neutralizing antibodies (bnAbs) directly from germline remains a barrier for HIV vaccines. HIV superinfection elicits bnAbs more frequently than single infection, providing clues of how to elicit such responses. We used…
View article: Author response: Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection
Author response: Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Stimulating broadly neutralizing antibodie…
View article: Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization
Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization Open
Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at eliciting cross-reactive neutralizing antibodie…
View article: Functional development of a V3-specific broadly neutralizing antibody isolated from a case of HIV superinfection
Functional development of a V3-specific broadly neutralizing antibody isolated from a case of HIV superinfection Open
Stimulating broadly neutralizing antibodies (bnAbs) directly from germline remains a barrier for HIV vaccines. HIV superinfection elicits bnAbs more frequently than single infection, providing clues of how to elicit such responses. We used…
View article: Functional development of a V3-specific broadly neutralizing antibody isolated from a case of HIV superinfection
Functional development of a V3-specific broadly neutralizing antibody isolated from a case of HIV superinfection Open
Stimulating broadly neutralizing antibodies (bnAbs) directly from germline remains a barrier for HIV vaccines. HIV superinfection elicits bnAbs more frequently than single infection, providing clues of how to elicit such responses. We used…
View article: Structural monitoring of a transient intermediate in the hemagglutinin fusion machinery on influenza virions
Structural monitoring of a transient intermediate in the hemagglutinin fusion machinery on influenza virions Open
Structural mass spectrometry enables dissection of a transient activated ensemble in influenza hemagglutinin fusion machinery.
View article: Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage
Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage Open
View article: Rapid development of an infant-derived HIV-1 broadly neutralizing antibody lineage
Rapid development of an infant-derived HIV-1 broadly neutralizing antibody lineage Open
Summary HIV-infected infants develop broadly neutralizing plasma responses with more rapid kinetics than adults, suggesting the ontogeny of infant responses could better inform a path to achievable vaccine targets. We developed computation…
View article: Assembly, maturation and three-dimensional helical structure of the teratogenic rubella virus
Assembly, maturation and three-dimensional helical structure of the teratogenic rubella virus Open
Viral infections during pregnancy are a significant cause of infant morbidity and mortality. Of these, rubella virus infection is a well-substantiated example that leads to miscarriages or severe fetal defects. However, structural informat…
View article: The cryoEM structures of immature and mature Zika virus and of mature Zika virus complexed with a human monoclonal antibody
The cryoEM structures of immature and mature Zika virus and of mature Zika virus complexed with a human monoclonal antibody Open
View article: Structure of the immature Zika virus at 9 Å resolution
Structure of the immature Zika virus at 9 Å resolution Open
View article: Structural Studies of Chikungunya Virus-Like Particles Complexed with Human Antibodies: Neutralization and Cell-to-Cell Transmission
Structural Studies of Chikungunya Virus-Like Particles Complexed with Human Antibodies: Neutralization and Cell-to-Cell Transmission Open
Chikungunya virus is a positive-stranded RNA alphavirus. Structures of chikungunya virus-like particles in complex with strongly neutralizing antibody Fab fragments (8B10 and 5F10) were determined using cryo-electron microscopy and X-ray c…