Vignesh Rammohan
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View article: Virtual physiological analysis of non-culprit disease in patients with STEMI and multivessel disease: a substudy of the COMPLETE trial
Virtual physiological analysis of non-culprit disease in patients with STEMI and multivessel disease: a substudy of the COMPLETE trial Open
Aims In the complete revascularization with multivessel PCI for myocardial infarction (COMPLETE) trial, staged complete revascularization in patients with ST-segment-elevation myocardial infarction (MI) reduced major adverse cardiovascular…
View article: Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve
Incorporating clinical parameters to improve the accuracy of angiography-derived computed fractional flow reserve Open
Aims Angiography-derived fractional flow reserve (angio-FFR) permits physiological lesion assessment without the need for an invasive pressure wire or induction of hyperaemia. However, accuracy is limited by assumptions made when defining …
View article: Virtual (Computed) Fractional Flow Reserve: Future Role in Acute Coronary Syndromes
Virtual (Computed) Fractional Flow Reserve: Future Role in Acute Coronary Syndromes Open
The current management of acute coronary syndromes (ACS) is with an invasive strategy to guide treatment. However, identifying the lesions which are physiologically significant can be challenging. Non-invasive imaging is generally not appr…
View article: The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography
The importance of three dimensional coronary artery reconstruction accuracy when computing virtual fractional flow reserve from invasive angiography Open
Three dimensional (3D) coronary anatomy, reconstructed from coronary angiography (CA), is now being used as the basis to compute ‘virtual’ fractional flow reserve (vFFR), and thereby guide treatment decisions in patients with coronary arte…
View article: Utilising clinical data to personlaise boundary conditions significantly improves the accuracy of angiography based virtual FFR
Utilising clinical data to personlaise boundary conditions significantly improves the accuracy of angiography based virtual FFR Open
Background Angiography-derived computed (virtual) fractional flow reserve (vFFR) permits the assessment of coronary physiology without the need for a pressure wire or hyperaemia. However, accuracy is limited by assumptions made about coron…
View article: The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study
The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study Open
Aims International guidelines mandate the use of fractional flow reserve (FFR) and/or non-hyperaemic pressure ratios to assess the physiological significance of moderate coronary artery lesions to guide revascularization decisions. However…
View article: 33 Absolute coronary blood flow and microvascular resistance modelling in patients with coronary artery disease
33 Absolute coronary blood flow and microvascular resistance modelling in patients with coronary artery disease Open
Background Ischaemic heart disease causes reduced coronary blood flow (CBF). CBF is not routinely measured in the catheterisation laboratory. Cardiologists therefore rely upon surrogate indices of CBF like fractional flow reserve (FFR). Wh…
View article: Operator-dependent variability of angiography-derived fractional flow reserve and the implications for treatment
Operator-dependent variability of angiography-derived fractional flow reserve and the implications for treatment Open
Aims To extend the benefits of physiologically guided percutaneous coronary intervention to many more patients, angiography-derived, or ‘virtual’ fractional flow reserve (vFFR) has been developed, in which FFR is computed, based upon the i…
View article: The Accuracy of Virtual Fractional Flow Reserve From Invasive Angiography: Importance of the Method of Reconstructing Three-dimensional Coronary Artery Anatomy
The Accuracy of Virtual Fractional Flow Reserve From Invasive Angiography: Importance of the Method of Reconstructing Three-dimensional Coronary Artery Anatomy Open
Background Three dimensional (3D) coronary anatomy, reconstructed from coronary angiography (CA), is now being used as the basis to compute ‘virtual’ fractional flow reserve (vFFR), and thereby guide treatment decisions in patients with co…
View article: The new role of diagnostic angiography in coronary physiological assessment
The new role of diagnostic angiography in coronary physiological assessment Open
The role of ‘stand-alone’ coronary angiography (CAG) in the management of patients with chronic coronary syndromes is the subject of debate, with arguments for its replacement with CT angiography on the one hand and its confinement to the …
View article: 113 Potential role of coronary physiology in treating ‘bystander’ disease in patients with ST-elevation myocardial infarction
113 Potential role of coronary physiology in treating ‘bystander’ disease in patients with ST-elevation myocardial infarction Open
Background Many patients with ST-segment elevation myocardial infarction (STEMI) have non-culprit lesions (NCLs) in other coronary arteries, for which optimal management is uncertain. In the COMPLETE trial, percutaneous coronary interventi…
View article: 16 Assessing the accuracy of a novel in silico imaging tool for the 3D reconstruction of coronary vasculature in the context of virtual fractional flow reserve
16 Assessing the accuracy of a novel in silico imaging tool for the 3D reconstruction of coronary vasculature in the context of virtual fractional flow reserve Open
Fractional flow reserve (FFR) is the gold standard method for guiding percutaneous coronary intervention. 'Virtual' FFR (vFFR) offers a less-invasive alternative but accuracy is critically dependent on accurate 3D arterial reconstruction.…