Setting: Increased lag time for diagnosis and treatment is a key determinant of adverse retinoblastoma (RB) outcomes. Analysis from INPHOG-RB-19-01, a prospective, multicentric study of newly diagnosed RB with regard to lag time and its correlation with various variables, is presented. Patient or Study Population: All newly diagnosed RB patients treated at the participating centers during the study period were enrolled. Observation Procedure: Lag time was subdivided into parent-lag time (symptom onset to first con…

The aim of this study was to retrospectively determine clinical features, treatment outcomes, and overall survival in four patients with metastatic retinoblastoma at presentation. The mean age at diagnosis was 63 months (range: 24–108 months). Three patients had overt orbital disease of at least one eye and one patient had microscopic orbital disease with scleral infiltration on histopathology. Metastatic sites included regional lymph nodes (RLN) ( n = 4), bone marrow (BM) ( n = 2), and cerebrospinal fluid (CSF) (…