Sangeeta S. Chavan
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View article: Nociceptor α7nAChR activation blunts neuronal HMGB1 release and attenuates inflammation and nociceptive behavior
Nociceptor α7nAChR activation blunts neuronal HMGB1 release and attenuates inflammation and nociceptive behavior Open
Background High Mobility Group Box 1 (HMGB1) is a nuclear protein that upon extracellular release acts as an alarmin to initiate and amplify inflammation. HMGB1 release from nociceptors contributes to both inflammation and pain; however, t…
View article: A Study of Clinical Profile of Hypertension in Elderly Age Group in Tertiary Care Hospital
A Study of Clinical Profile of Hypertension in Elderly Age Group in Tertiary Care Hospital Open
Introduction: Decompensated alcoholic liver disease (DALD) is a major cause of morbidity and mortality worldwide, with complications including ascites, hepatic encephalopathy, hepatorenal syndrome, and spontaneous bacterial peritonitis. Hy…
View article: The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice
The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice Open
View article: Myelin oligodendrocyte glycoprotein antibody-associated disease: A central nervous system demyelinating disorder – Case report
Myelin oligodendrocyte glycoprotein antibody-associated disease: A central nervous system demyelinating disorder – Case report Open
MOGAD, or Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, is a less-known demyelinating disease that causes inflammation to the CNS (central nervous system) and has been known for a few recent years. It is observed to be i…
View article: The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice
The cholinergic drug galantamine ameliorates acute and subacute peripheral and brain manifestations of acute respiratory distress syndrome in mice Open
Acute respiratory distress syndrome (ARDS) is a life-threatening form of acute lung injury (ALI), which is a common cause of respiratory failure and high mortality in critically ill patients. Long-term mortality and brain dysfunction have …
View article: Neural representation of cytokines by vagal sensory neurons
Neural representation of cytokines by vagal sensory neurons Open
View article: Comparative Evaluation of Shear Bond Strength between Pullulan-enhanced Bonding Agent and Conventional Bonding Agent: An In Vitro Study
Comparative Evaluation of Shear Bond Strength between Pullulan-enhanced Bonding Agent and Conventional Bonding Agent: An In Vitro Study Open
View article: Use of focused ultrasound neuromodulation of peripheral neural circuits to treat inflammation in cardiopulmonary disorders and pain
Use of focused ultrasound neuromodulation of peripheral neural circuits to treat inflammation in cardiopulmonary disorders and pain Open
View article: Cytokine-responsive neurons in the bed nucleus of the stria terminalis activate acute stress response
Cytokine-responsive neurons in the bed nucleus of the stria terminalis activate acute stress response Open
View article: Survey of AI Techniques for Disaster Response and Recovery Using Aerial and Satellite Imagery
Survey of AI Techniques for Disaster Response and Recovery Using Aerial and Satellite Imagery Open
View article: Evaluating the Impact of Depression, Anxiety, Occupational Stress and its Related Factors on Sleep Quality among Dental Practitioners in Madurai City – An Analytical Cross Sectional Study
Evaluating the Impact of Depression, Anxiety, Occupational Stress and its Related Factors on Sleep Quality among Dental Practitioners in Madurai City – An Analytical Cross Sectional Study Open
Background: The field of dentistry is renowned not only for its intricate nature and professionalism but also high stress that permeating into realm of sleep health with serious mental health. Aim: This study aimed to assess the prevalen…
View article: Awareness and Perceptions Regarding E-Pharmacies among the General Population Aged above 18 Years in Madurai City- A Cross Sectional Study
Awareness and Perceptions Regarding E-Pharmacies among the General Population Aged above 18 Years in Madurai City- A Cross Sectional Study Open
Background E-pharmacies are rapidly transforming the way people access medications. This study will identify evolving patterns in e-pharmacy utilization and analyze the factors influencing consumer choice, such as convenience, cost, produc…
View article: Early brain neuroinflammatory and metabolic changes identified by dual tracer microPET imaging in mice with acute liver injury
Early brain neuroinflammatory and metabolic changes identified by dual tracer microPET imaging in mice with acute liver injury Open
Background Acute liver injury (ALI) that progresses into acute liver failure (ALF) is a life-threatening condition with an increasing incidence and associated costs. Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosing is among the lead…
View article: TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens
TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens Open
View article: Nerve stimulation for treatment of diseases and disorders
Nerve stimulation for treatment of diseases and disorders Open
Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or…
View article: Correction: Galantamine ameliorates experimental pancreatitis
Correction: Galantamine ameliorates experimental pancreatitis Open
View article: Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation
Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation Open
Introduction: The vagus nerve innervates multiple organs, but its role in regulating cross-tissue spread of inflammation is as yet unclear. We hypothesized that the vagus nerve may regulate cross-tissue inflammation via modulation of the p…
View article: Circulating extracellular choline acetyltransferase regulates inflammation
Circulating extracellular choline acetyltransferase regulates inflammation Open
Background Choline acetyltransferase (ChAT) is required for the biosynthesis of acetylcholine, the molecular mediator that inhibits cytokine production in the cholinergic anti‐inflammatory pathway of the vagus nerve inflammatory reflex. Ab…
View article: Galantamine ameliorates experimental pancreatitis
Galantamine ameliorates experimental pancreatitis Open
View article: Comparative evaluation of anti-bacterial effect of Caesalpinia sappan aqueous extract and 0.12% Chlorhexidine against Streptococcus mutans – An in vitro study
Comparative evaluation of anti-bacterial effect of Caesalpinia sappan aqueous extract and 0.12% Chlorhexidine against Streptococcus mutans – An in vitro study Open
Aim and objectives: To evaluate and compare the antimicrobial activity of various concentration of C.sappan wood aqueous extract (100mg/ml, 200mg/ml, 300mg/ml, 400mg/ml, 500mg/ml and 600mg/ml) and 0.12% chlorhexidine mouthwash using agar w…
View article: Clinical estimation of anticaries effect of probiotic toothpaste among 18-25 years old young adults- A double blinded randomized controlled trial
Clinical estimation of anticaries effect of probiotic toothpaste among 18-25 years old young adults- A double blinded randomized controlled trial Open
Aim & Objectives: The aim and objective of the study was to estimate the anticaries effect of probiotic toothpaste by assessing the Streptococcus mutans and Lactobacillus levels and by recording indices before and after intervention among …
View article: Clinical practice perception in relation with DEPTh model among dental practitioners in Madurai city -A cross sectional study
Clinical practice perception in relation with DEPTh model among dental practitioners in Madurai city -A cross sectional study Open
Introduction : Clinical epidemiology is a science of making predictions, which aims at promoting the quality of clinical and patient oriented health care, in order to make good decision in care of patients. The study aimed to assess the pe…
View article: Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice
Vagus nerve stimulation primes platelets and reduces bleeding in hemophilia A male mice Open
View article: Electrical stimulation of the dorsal motor nucleus of the vagus regulates inflammation without affecting the heart rate
Electrical stimulation of the dorsal motor nucleus of the vagus regulates inflammation without affecting the heart rate Open
Background The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal m…
View article: Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis
Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis Open
Introduction Inflammation is an inherently self-amplifying process, resulting in progressive tissue damage when unresolved. A brake on this positive feedback system is provided by the nervous system which has evolved to detect inflammatory…
View article: Editorial: Understanding and targeting neuro-immune interactions within disease and inflammation
Editorial: Understanding and targeting neuro-immune interactions within disease and inflammation Open
EDITORIAL article Front. Immunol., 18 April 2023Sec. Multiple Sclerosis and Neuroimmunology Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1201669
View article: Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans
Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans Open
Focused ultrasound stimulation (FUS) activates mechanosensitive ion channels and is emerging as a method of noninvasive neuromodulation. In preclinical studies, FUS of the spleen (sFUS) activates an anti-inflammatory neural pathway which s…
View article: Calcium imaging and analysis of the jugular-nodose ganglia enables identification of distinct vagal sensory neuron subsets
Calcium imaging and analysis of the jugular-nodose ganglia enables identification of distinct vagal sensory neuron subsets Open
Objective. Sensory nerves of the peripheral nervous system (PNS) transmit afferent signals from the body to the brain. These peripheral nerves are composed of distinct subsets of fibers and associated cell bodies, which reside in periphera…
View article: Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses
Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses Open
Background Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β) and other cytokines produced during inflammatory responses activate sensory neurons (noci…
View article: A dual tracer [11C]PBR28 and [18F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia
A dual tracer [11C]PBR28 and [18F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia Open