Vijay R. Ramakrishnan
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View article: Pollen Exposure and Chronic Rhinosinusitis Quality of Life Disease Severity
Pollen Exposure and Chronic Rhinosinusitis Quality of Life Disease Severity Open
Background Environmental factors, such as air irritants, may play an important role in chronic rhinosinusitis (CRS); however, no studies to date have examined the role of pollen in CRS disease severity. Here, we analyze the effects of poll…
View article: Are Endoscopic Sinus Surgery Complication Rates Improving Over Time and With the Adoption of Image Guidance?
Are Endoscopic Sinus Surgery Complication Rates Improving Over Time and With the Adoption of Image Guidance? Open
Background Endoscopic sinus surgery (ESS) continues to be widely used as a treatment for refractory chronic rhinosinusitis (CRS). With advancements in technology and surgical technique, we might expect fewer surgical complications to occur…
View article: The Development and Validation of the Smell‐Qx Questionnaire, Based on a Systematic Review of the Literature and the COMET Initiative on the Development of Core Outcome Sets for Clinical Trials in Olfactory Disorders
The Development and Validation of the Smell‐Qx Questionnaire, Based on a Systematic Review of the Literature and the COMET Initiative on the Development of Core Outcome Sets for Clinical Trials in Olfactory Disorders Open
Background Olfactory dysfunction affects up to 22% of the population. Accurate assessment is vital for diagnosis and tracking outcomes, often using patient‐reported outcome measures (PROMs). Aims We aimed to develop and validate a novel qu…
View article: A Systematic Classification of Surgical Approaches for the Sphenoid Sinus: Establishing a Standardized Nomenclature for Endoscopic Sphenoid Sinus Surgery
A Systematic Classification of Surgical Approaches for the Sphenoid Sinus: Establishing a Standardized Nomenclature for Endoscopic Sphenoid Sinus Surgery Open
The sphenoid sinus presents significant challenges during endoscopic sinus surgery. It is essential that surgeons employ strategies that effectively address sphenoid pathology while minimizing surgical risks and optimizing outcomes. Althou…
View article: Mediation of LPS‐Induced Inflammation With Pro‐Resolving Treatment in Human Nasal Polyps: A Pilot Study
Mediation of LPS‐Induced Inflammation With Pro‐Resolving Treatment in Human Nasal Polyps: A Pilot Study Open
View article: High‐Riding Innominate Artery: Booby Trap for <scp>ICU</scp> Tracheotomy
High‐Riding Innominate Artery: Booby Trap for <span>ICU</span> Tracheotomy Open
Despite tracheotomy being a routine procedure, it is not rare to encounter anatomic irregularities that can compromise its success. In this report, we describe a case in which a high riding innominate artery was identified within the surgi…
View article: Multi‐institutional validation of an AI‐based sinus CT analytic platform with olfactory assessments
Multi‐institutional validation of an AI‐based sinus CT analytic platform with olfactory assessments Open
Key points AI‐based CT sinus analysis may have advantages over visual based systems, for example, Lund–Mackay score. Here, we show multi‐institutional validation of an AI algorithm using novel OMC classification. Significant, robust correl…
View article: Features of Importance in Nasal Endoscopy: Deriving a Meaningful Framework
Features of Importance in Nasal Endoscopy: Deriving a Meaningful Framework Open
Objective Critical components of the nasal endoscopic examination have not been definitively established for either the normal examination or for clinical disorders. This study aimed to identify concordance among rhinologists regarding the…
View article: Health care disparities and chronic rhinosinusitis: Does neighborhood disadvantage impact outcomes in sinonasal disease?
Health care disparities and chronic rhinosinusitis: Does neighborhood disadvantage impact outcomes in sinonasal disease? Open
Objective Socioeconomic status (SES) is linked to health outcomes but has not been well studied in patients with chronic rhinosinusitis (CRS). The area deprivation index (ADI) is a comprehensive measure of geographic SES that ranks neighbo…
View article: Comparison of Sinus Flora Using Various Next-Generation Sequencing Techniques Versus Standard Culturing
Comparison of Sinus Flora Using Various Next-Generation Sequencing Techniques Versus Standard Culturing Open
Background:Next generation sequencing methods are being developed to help diagnose infectious diseases at the point of care and to help resolve discrepant results. These new methods hope to replace longer, more tedious sequencing methods s…
View article: Validation of Blunting of Inflammatory Markers in LPS Induced Tissue with SPM Treatment
Validation of Blunting of Inflammatory Markers in LPS Induced Tissue with SPM Treatment Open
Background and Hypothesis: Chronic rhinosinusitis (CRS) is defined as persistent inflammation of the mucosa of the nose and paranasal sinuses, either with or without nasal polyps. The pathophysiology of CRS is thought to occur due to a dys…
View article: Physician views of artificial intelligence in otolaryngology and rhinology: A mixed methods study
Physician views of artificial intelligence in otolaryngology and rhinology: A mixed methods study Open
Objective The study aimed to investigate otolaryngologists' knowledge, trust, acceptance, and concerns with clinical applications of artificial intelligence (AI). Methods This study used mixed methods with survey and semistructured intervi…
View article: INFECTION OF HUMAN OLFACTORY EPITHELIUM WITH ALPHAHERPESVIRUS ELICITS EXPRESSION OF BETA AMYLOID.
INFECTION OF HUMAN OLFACTORY EPITHELIUM WITH ALPHAHERPESVIRUS ELICITS EXPRESSION OF BETA AMYLOID. Open
View article: All chronic rhinosinusitis endotype clusters demonstrate improvement in patient‐reported and clinical outcome measures after endoscopic sinus surgery
All chronic rhinosinusitis endotype clusters demonstrate improvement in patient‐reported and clinical outcome measures after endoscopic sinus surgery Open
Background It is unclear whether chronic rhinosinusitis (CRS) endotypes show a differential response to endoscopic sinus surgery (ESS). We explored patient mucous inflammatory cytokine expression and associations with patient‐reported and …
View article: Inflammation resolution and specialized pro-resolving lipid mediators in chronic rhinosinusitis
Inflammation resolution and specialized pro-resolving lipid mediators in chronic rhinosinusitis Open
Temporal phases of resolution must be tightly regulated to successfully resolve inflammation in CRS while preserving tissue functions such as barrier maintenance and special sensory function. Dysregulation of SPM enzymatic pathways has bee…
View article: Pneumocephalus following sneeze suppression
Pneumocephalus following sneeze suppression Open
Pneumocephalus is defined as air in the intracranial space. It is commonly caused by traumatic skull fractures and is diagnosed by head plain computer tomography. Treatment involves initial stabilization of vital signs and surgical interve…
View article: Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough
Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough Open
Background Antagonists to the P2X purinergic receptors on airway sensory nerves relieve refractory or unexplained chronic cough (RCC/UCC) but can evoke unwanted dysgeusias because the gustatory nerves innervating taste buds express this sa…
View article: Testing specialized pro-resolving mediators on bacteria-derived inflammation in chronic rhinosinusitis
Testing specialized pro-resolving mediators on bacteria-derived inflammation in chronic rhinosinusitis Open
Background and Hypothesis:Chronic rhinosinusitis (CRS) is defined by chronic tissue inflammation, and prior work in the field implicates activation of the NFκb pathway. This pathway is activated by pattern recognition receptors (PRRs), whi…
View article: Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease
Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease Open
View article: Table of Contents
Table of Contents Open
View article: Clinical Validation and Extension of an Automated, Deep Learning–Based Algorithm for Quantitative Sinus CT Analysis
Clinical Validation and Extension of an Automated, Deep Learning–Based Algorithm for Quantitative Sinus CT Analysis Open
Our quantitative processing of sinus CT images provides objective measures that correspond well to established visual scoring methods. While automation is a clear benefit here, validation may be needed in a prospective, multi-institutional…
View article: Work productivity and activity impairment in patients with chronic rhinosinusitis undergoing endoscopic sinus surgery—A prospective, multi‐institutional study
Work productivity and activity impairment in patients with chronic rhinosinusitis undergoing endoscopic sinus surgery—A prospective, multi‐institutional study Open
Background Productivity loss and activity limitations due to chronic rhinosinusitis (CRS) are known to contribute to the significant economic and personal burden of disease. The purpose of this study was to assess productivity and activity…
View article: Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer’s Disease
Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer’s Disease Open
Objective Alzheimer’s disease (AD) is characterized by loss of smell and olfactory system pathology that precedes the diagnosis of dementia. Understanding these early processes can potentially identify diagnostic and therapeutic targets to…
View article: Infection and inflammation in chronic rhinosinusitis: Gene ontology/pathway analysis perspective
Infection and inflammation in chronic rhinosinusitis: Gene ontology/pathway analysis perspective Open
View article: Objective and patient‐based measures of chronic rhinosinusitis in people with cystic fibrosis treated with highly effective modulator therapy
Objective and patient‐based measures of chronic rhinosinusitis in people with cystic fibrosis treated with highly effective modulator therapy Open
The highly effective cystic fibrosis transmembrane conductance regulator modulator therapy (HEMT) with elexacaftor/tezacaftor/ivacaftor (ETI) improves pulmonary disease and chronic rhinosinusitis (CRS) in people with cystic fibrosis (PwCF)…
View article: Evaluating Distance Bias in Chronic Rhinosinusitis Outcomes
Evaluating Distance Bias in Chronic Rhinosinusitis Outcomes Open
ClinicalTrials.gov Identifier: NCT02720653.
View article: Use of a novel chinchilla skull base repair model to test a photo‐initiated thiol‐ene biopolymer
Use of a novel chinchilla skull base repair model to test a photo‐initiated thiol‐ene biopolymer Open
Peter Mariner, PhD, has a former affiliation with Mosaic Biosciences. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing con…
View article: Unraveling the role of the microbiome in chronic rhinosinusitis
Unraveling the role of the microbiome in chronic rhinosinusitis Open
View article: Impact of Airline Secondhand Tobacco Smoke Exposure on Respiratory Health and Lung Function Decades After Exposure Cessation
Impact of Airline Secondhand Tobacco Smoke Exposure on Respiratory Health and Lung Function Decades After Exposure Cessation Open
View article: A dysbiotic microbiome promotes head and neck squamous cell carcinoma
A dysbiotic microbiome promotes head and neck squamous cell carcinoma Open