Vijayalekshmi Sarojini
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View article: ε‐Poly‐L‐lysine‐<i>graft</i>‐oligo(3‐hexylthiophene) Copolymers as Antibacterial and Biodegradable Polymer Electronics
ε‐Poly‐L‐lysine‐<i>graft</i>‐oligo(3‐hexylthiophene) Copolymers as Antibacterial and Biodegradable Polymer Electronics Open
Biodegradable polymer electronics offer an innovative solution to the growing challenge of electronic waste, which are engineered to disintegrate after a defined functional period. Here, a new class of graft copolymer is presented, ε‐poly‐…
View article: Adjuvant strategies to tackle <i>mcr</i> -mediated polymyxin resistance
Adjuvant strategies to tackle <i>mcr</i> -mediated polymyxin resistance Open
The emergence of the mobile colistin resistance ( mcr ) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant …
View article: Rational design of self‐assembling ultrashort peptides for the shape‐ and size‐tunable synthesis of metal nanostructures
Rational design of self‐assembling ultrashort peptides for the shape‐ and size‐tunable synthesis of metal nanostructures Open
Peptides have attracted great interest as platforms for the design of nanocomposite hydrogels due to their distinct bioactivity, biofunctionality and biocompatibility. Previously, we have reported on a family of peptides that self‐assemble…
View article: Antimicrobial fibres derived from aryl-diazonium conjugation of chitosan with Harakeke (Phormium tenax) and Hemp (Cannabis sativa) Hurd
Antimicrobial fibres derived from aryl-diazonium conjugation of chitosan with Harakeke (Phormium tenax) and Hemp (Cannabis sativa) Hurd Open
Surface functionalisation of natural materials to develop sustainable and environmentally friendly antimicrobial fibres has received great research interest in recent years. Herein, chitosan covalent conjugation via aryl-diazonium based ch…
View article: Development of truncated Battacin antimicrobials featuring novel N-terminal fatty acids with an excellent safety profile
Development of truncated Battacin antimicrobials featuring novel N-terminal fatty acids with an excellent safety profile Open
Octapeptin B5 peptides containing a novel fatty acids have been found to have enhanced antibacterial activity against Staphylococcus aureus and also have an excellent safety profile. Cyclic lipopeptides such as the polymyxins and battacin …
View article: Evaluating the potential of environmentally friendly compounds to deactivate different life stages of <i>Phytophthora</i> species
Evaluating the potential of environmentally friendly compounds to deactivate different life stages of <i>Phytophthora</i> species Open
Phytophthora species are a genus in the oomycete class and are destructive plant pathogens. The ability to inhibit all stages in the life cycle of these aggressive Phytophthora pathogens is essential for the long‐term protection of native …
View article: Editorial: Food bioactives: Implications for meeting Sustainable Development Goals
Editorial: Food bioactives: Implications for meeting Sustainable Development Goals Open
EDITORIAL article Front. Sustain. Food Syst., 30 January 2023Sec. Sustainable Food Processing Volume 7 - 2023 | https://doi.org/10.3389/fsufs.2023.1137862
View article: Mechanistic insight into functionally different human islet polypeptide (hIAPP) amyloid: the intrinsic role of the C-terminal structural motifs
Mechanistic insight into functionally different human islet polypeptide (hIAPP) amyloid: the intrinsic role of the C-terminal structural motifs Open
Targeting amyloidosis requires high-resolution insight into the underlying mechanisms of amyloid aggregation.
View article: Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2
Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2 Open
Hypoxia‐inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals. By using the CO‐releasing molecule‐2 (CORM‐2) as an in situ CO donor, we demonstrate that CO is an inhibitor of PHD2. This report provide…
View article: Molecular engineering of antimicrobial peptides: microbial targets, peptide motifs and translation opportunities
Molecular engineering of antimicrobial peptides: microbial targets, peptide motifs and translation opportunities Open
The global public health threat of antimicrobial resistance has led the scientific community to highly engage into research on alternative strategies to the traditional small molecule therapeutics. Here, we review one of the most popular a…
View article: Structural characterization of a PCP–R didomain from an archaeal nonribosomal peptide synthetase reveals novel interdomain interactions
Structural characterization of a PCP–R didomain from an archaeal nonribosomal peptide synthetase reveals novel interdomain interactions Open
Nonribosomal peptide synthetases (NRPSs) are multimodular enzymes that produce a wide range of bioactive peptides, such as siderophores, toxins, and antibacterial and insecticidal agents. NRPSs are dynamic proteins characterized by extensi…
View article: Molecular Dynamics Simulation of the Interaction of Two Linear Battacin Analogs with Model Gram-Positive and Gram-Negative Bacterial Cell Membranes
Molecular Dynamics Simulation of the Interaction of Two Linear Battacin Analogs with Model Gram-Positive and Gram-Negative Bacterial Cell Membranes Open
Antimicrobial peptides (AMPs) are a potential solution to the increasing threat of antibiotic resistance, but successful design of active but nontoxic AMPs requires understanding their mechanism of action. Molecular dynamics (MD) simulatio…
View article: Covalently Immobilized Battacin Lipopeptide Gels with Activity against Bacterial Biofilms
Covalently Immobilized Battacin Lipopeptide Gels with Activity against Bacterial Biofilms Open
Novel antibiotic treatments are in increasing demand to tackle life-threatening infections from bacterial pathogens. In this study, we report the use of a potent battacin lipopeptide as an antimicrobial gel to inhibit planktonic and mature…
View article: Synthesis and Antibacterial Analysis of Analogues of the Marine Alkaloid Pseudoceratidine
Synthesis and Antibacterial Analysis of Analogues of the Marine Alkaloid Pseudoceratidine Open
In an effort to gain more understanding on the structure activity relationship of pseudoceratidine 1, a di-bromo pyrrole spermidine alkaloid derived from the marine sponge Pseudoceratina purpurea that has been shown to exhibit potent biofo…
View article: An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant
An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant Open
An investigation using recombinant ribosomal proteins and synthetic peptide models was conducted to uncover the effect of the introduction of a negative charge at the C-terminal tail of ribosomal protein S15.
View article: Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations
Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations Open
Cell-penetrating peptide conjugated peptide aldehydes Tat-A and Tat-B showed low micromolar anticancer and antifungal activities and synergistic action in combination with cisplatin and amphotericin B against cancer and funga…
View article: CCDC 1915581: Experimental Crystal Structure Determination
CCDC 1915581: Experimental Crystal Structure Determination Open
View article: CCDC 1915580: Experimental Crystal Structure Determination
CCDC 1915580: Experimental Crystal Structure Determination Open
View article: Protein Levels and Microstructural Changes in Localized Regions of Early Cartilage Degeneration Compared with Adjacent Intact Cartilage
Protein Levels and Microstructural Changes in Localized Regions of Early Cartilage Degeneration Compared with Adjacent Intact Cartilage Open
Objective It was hypothesized that the respective protein profiles of bovine cartilage from sites of localized mild to moderate (GI to GII) degeneration versus adjacent sites of intact tissue would vary in accordance with the tissue micros…
View article: Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An <i>in vitro</i> boron neutron capture therapy study
Cyclic-RGDyC functionalized liposomes for dual-targeting of tumor vasculature and cancer cells in glioblastoma: An <i>in vitro</i> boron neutron capture therapy study Open
The efficacy of boron neutron capture therapy depends on the selective delivery of 10B to the target. Integrins αvβ3 are transmembrane receptors over-expressed in both glioblastoma cells and its neovasculature. In this study, a novel appro…
View article: Synthetic insect antifreeze peptides modify ice crystal growth habit
Synthetic insect antifreeze peptides modify ice crystal growth habit Open
Synthetic antifreeze peptides based on the hyperactive antifreeze protein modify the shape of ice crystals and show enhanced antifreeze activity with the addition of a small molecule.
View article: Computational Assessment of Dose due to Primordial Radionuclides in Soils of Coastal Regions of Kanyakumari District in Tamil Nadu, India
Computational Assessment of Dose due to Primordial Radionuclides in Soils of Coastal Regions of Kanyakumari District in Tamil Nadu, India Open
The natural radioactivity due to uranium, Thorium and potassium in soil contributes to the radiation dose received by human beings significantly. Gamma ray spectrometric measurements carried out for the natural radioactivity levels due to …