Vikas Jhawat
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View article: Eudragit RS100 nanoparticles for sustained release of Cefpodoxime Proxetil: preparation, pharmaceutical characterization, and in-vitro drug release studies
Eudragit RS100 nanoparticles for sustained release of Cefpodoxime Proxetil: preparation, pharmaceutical characterization, and in-vitro drug release studies Open
Objective(s): The primary objective of this study was to develop a sustained-release formulation of cefpodoxime proxetil (CP) using the polymer Eudragit RS 100 (ERS100).Materials and Methods: Pluronic F127 (PF127) was incorporated as an am…
View article: Development and characterization of a gallic acid-infused topical emulgel for enhanced wound management: formulation and i <i>n vitro</i> optimization
Development and characterization of a gallic acid-infused topical emulgel for enhanced wound management: formulation and i <i>n vitro</i> optimization Open
Development of topical emulgel containing gallic acid for wound healing.
View article: Design Strategies for Improving Oral Bioavailability of Tizanidine: Solid Dispersion Approach
Design Strategies for Improving Oral Bioavailability of Tizanidine: Solid Dispersion Approach Open
Tizanidine is a poorly soluble drug that helps relax muscles and lower mild blood pressure. Solid dispersion of tinidazole may improve the solubility of the drug. The method involved mixing tizanidine with Soluplus in different amounts usi…
View article: Development of a Comprehensive Regulatory Model for Medical Devices
Development of a Comprehensive Regulatory Model for Medical Devices Open
Background: The development of a comprehensive regulatory model for medical devices is essential to ensure the safety, efficacy, and quality of medical devices throughout their lifecycle, from design and development to post-market surveill…
View article: Comparative Materiovigilance Program for US, Europe, Japan, India and Proposed Reporting Mechanism for Indian Scenario
Comparative Materiovigilance Program for US, Europe, Japan, India and Proposed Reporting Mechanism for Indian Scenario Open
Medical devices are thought to be a blessing for the healthcare system because they are tools that can save lives. Apart from therapeutic potential, these devices have lot of negative side effects. It took a strong cohort attentive system …
View article: Physiological Pathway, diagnosis and nanotechnology based treatment strategies for ovarian Cancer: A review
Physiological Pathway, diagnosis and nanotechnology based treatment strategies for ovarian Cancer: A review Open
Ovarian cancer is a fatal disease requiring great attention from the scientific community to find novel ways for diagnosis and treatment. Most ovarian malignancies, or 90% of cases, are epithelial ovarian cancers. HGSC (High Grade Ovarian …
View article: Utilization of kinase inhibitors as novel therapeutic drug targets: A review
Utilization of kinase inhibitors as novel therapeutic drug targets: A review Open
Kinase inhibitors are a significant and continuously developing division of target therapeutics. The drug discovery and improvement efforts have examined numerous attempts to target the signaling pathway of kinases. The Kinase inhibitors h…
View article: Formulation and Quality Control Tests for Nanoemulsion of Tofacitinib: A Novel Approach
Formulation and Quality Control Tests for Nanoemulsion of Tofacitinib: A Novel Approach Open
Background: Tofacitinib (TFB) is a pioneer JAK (Janus kinase) inhibitor mainly employed to treat rheumatoid arthritis. It has proven efficacy for the treatment of rheumatoid arthritis in the oral dosage form. Oral TFB exhibited several tox…
View article: Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension
Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension Open
The paper aimed to progress an ideal gastro retentive drug delivery system intended for directing Losartan and Hydrochlorothiazide as a fixed-dose combination for anti-hypertensive therapy. The bilayer tablets were primed through direct co…
View article: Unwinding Complexities of Diabetic Alzheimer by Potent Novel Molecules
Unwinding Complexities of Diabetic Alzheimer by Potent Novel Molecules Open
Diabetes mellitus is one of the aggressive disorders in global society. No pharmacotherapy is available for permanent diabetes cure, although management is possible with drugs and physical activities. One of the recent complications notice…
View article: Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension
Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension Open
Background: Different antihypertensive therapies (especially diuretics) are reported to induce the new onset of diabetes in some hypertensive patients. α-adducin-1 (ADD1) gene is salt sensitive gene which has its role in etiology of hypert…
View article: Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism Is Not Responsible for Antihypertensive Therapy Induced New Onset of Type 2 Diabetes in Essential Hypertension
Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism Is Not Responsible for Antihypertensive Therapy Induced New Onset of Type 2 Diabetes in Essential Hypertension Open
Background: Antihypertensive drug therapies have been reported to be associated with new onset of type 2 diabetes mellitus in some hypertensive patients after prolonged use. Angiotensin converting enzyme (ACE) gene has been found to affect…
View article: PREVALENCE AND RISK FACTORS OF ESSENTIAL HYPERTENSION AND NEW ONSET OF DIABETES IN ESSENTIAL HYPERTENSION IN RURAL POPULATION OF HARYANA
PREVALENCE AND RISK FACTORS OF ESSENTIAL HYPERTENSION AND NEW ONSET OF DIABETES IN ESSENTIAL HYPERTENSION IN RURAL POPULATION OF HARYANA Open
Objective: We conducted a well-designed prevalence study in a rural population of Haryana in Mullana rural area to find out the latest prevalence of essential hypertension, the prescription pattern of antihypertensive drugs and the associa…
View article: Formulation and evaluation of novel controlled release of topical pluronic lecithin organogel of mefenamic acid
Formulation and evaluation of novel controlled release of topical pluronic lecithin organogel of mefenamic acid Open
In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical carrier for controlled delivery of mefenamic acid. Ten organogel formulations were prepared by a method employing lecithin as lipophilic phase a…