Vikas Khillan
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View article: Thinking beyond Tuberculosis: Pulmonary Nocardiosis by Nocardia farcinica in a Patient with Autoimmune Hepatitis
Thinking beyond Tuberculosis: Pulmonary Nocardiosis by Nocardia farcinica in a Patient with Autoimmune Hepatitis Open
Nocardiosis is a rare but serious infection caused by Nocardia species (class Actinobacteria, order Corynebacteriales). Nocardia is commonly found in soil, dust and plant material, and the infection primarily affects immunocompromised indi…
View article: Preoperative infection within a month is associated with inferior post-transplant outcomes in adult living donor liver transplants
Preoperative infection within a month is associated with inferior post-transplant outcomes in adult living donor liver transplants Open
Background: Preoperative infection is a major determinant of outcome following liver transplant. The current study aims to assess the impact of the interval between preoperative infection and transplantation on post-operative outcomes foll…
View article: Utility of CBNAAT (GeneXpert MTB/RIF assay) in rapid diagnosis of extrapulmonary tuberculosis in a hepatobiliary tertiary center
Utility of CBNAAT (GeneXpert MTB/RIF assay) in rapid diagnosis of extrapulmonary tuberculosis in a hepatobiliary tertiary center Open
Objectives Newer diagnostic techniques like cartridge-based nucleic acid amplification techniques (CB NAAT) need to be evaluated for extrapulmonary tuberculosis (EPTB), as being a paucibacillary condition, it is often underdiagnosed with c…
View article: Cryptococcosis among HIV negative liver disease patients: Epidemiology, underlying conditions, antifungal susceptibility profile from tertiary care hepatobiliary center
Cryptococcosis among HIV negative liver disease patients: Epidemiology, underlying conditions, antifungal susceptibility profile from tertiary care hepatobiliary center Open
According to the study liver conditions are a significant risk factor for cryptococcal infection. Therefore, cryptococcal isolation and antifungal susceptibility testing, as well as appropriate antifungal drug use, should be studied and pa…
View article: Delhi's network for surveillance of antimicrobial resistance: The journey, challenges and output from first year
Delhi's network for surveillance of antimicrobial resistance: The journey, challenges and output from first year Open
There are many challenges in generating quality AMR data in lower-middle-income countries. There is a need for resource allocation and capacity building at all levels to ensure the collection of quality assured data.
View article: P406 Rise in HIV negative Cryptococcal infection in liver disease patient: epidemiology, risk factor, antifungal susceptibility profile from tertiary care hepatobiliary center
P406 Rise in HIV negative Cryptococcal infection in liver disease patient: epidemiology, risk factor, antifungal susceptibility profile from tertiary care hepatobiliary center Open
Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objective Cryptococcus neoformans is an encapsulated yeast found ubiquitously in the environment, considered important in immunocompromised individuals with HIV. Non-HIV susceptible …
View article: P141 Study of prevalence, antifungal profile and predictors of mortality in chronic pulmonary Aspergillosis in a cohort of liver disease patient
P141 Study of prevalence, antifungal profile and predictors of mortality in chronic pulmonary Aspergillosis in a cohort of liver disease patient Open
Poster session 2, September 22, 2022, 12:30 PM - 1:30 PM Objectives Chronic pulmonary aspergillosis (CPA) is a neglected cause of respiratory disease even in high-TB burden countries like India. It is a term that includes simple aspergillo…
View article: P409 Study of epidemiology, risk factors and antifungal sensitivity pattern of fungal pneumonia in critically ill cirrhotics
P409 Study of epidemiology, risk factors and antifungal sensitivity pattern of fungal pneumonia in critically ill cirrhotics Open
Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Liver cirrhosis causes immune dysregulation and increased susceptibility to fungal infections. We studied the epidemiology and risk factors, and compared the rapid diagnos…
View article: P438 Epidemiology, risk factor analysis and management of invasive <i>Candida auris</i> infections in tertiary care hepatobiliary center in India
P438 Epidemiology, risk factor analysis and management of invasive <i>Candida auris</i> infections in tertiary care hepatobiliary center in India Open
Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Candida auris (C. auris) infections are associated with misidentification, intrahospital transmission, poor treatment outcomes, and higher mortalities. Prompt detection, e…
View article: Vaccine Breakthrough Infections by SARS-CoV-2 Variants after ChAdOx1 nCoV-19 Vaccination in Healthcare Workers
Vaccine Breakthrough Infections by SARS-CoV-2 Variants after ChAdOx1 nCoV-19 Vaccination in Healthcare Workers Open
This study elucidated the clinical, humoral immune response and genomic analysis of vaccine breakthrough (VBT) infections after ChAdOx1 nCoV-19/Covishield vaccine in healthcare workers (HCWs). Amongst 1858 HCWs, 1639 had received either tw…
View article: Invasive Candida auris Infections: Epidemiology, Risk Factor Analysis and Management in Tertiary Care Hepatobiliary Centre
Invasive Candida auris Infections: Epidemiology, Risk Factor Analysis and Management in Tertiary Care Hepatobiliary Centre Open
View article: Clinicogenomic analysis of breakthrough infections by SARS CoV2 variants after ChAdOx1 nCoV- 19 vaccination in healthcare workers
Clinicogenomic analysis of breakthrough infections by SARS CoV2 variants after ChAdOx1 nCoV- 19 vaccination in healthcare workers Open
Background India saw a massive surge and emergence of SARS CoV2 variants. We elucidated clinical and humoral immune response and genomic analysis of vaccine breakthrough (VBT) infections after ChAdOx1 nCoV-19 vaccine in healthcare workers …
View article: Post-fecal microbiota transplant taxa correlate with 3-month survival in severe alcoholic hepatitis patients
Post-fecal microbiota transplant taxa correlate with 3-month survival in severe alcoholic hepatitis patients Open
View article: Comparative Evaluation of Echinococcus Serology with Cytology for the Diagnosis of Hepatic Hydatid Disease
Comparative Evaluation of Echinococcus Serology with Cytology for the Diagnosis of Hepatic Hydatid Disease Open
Objectives The purpose of this study is to determine the diagnostic efficacy of enzyme-linked immunosorbent assay (ELISA) in radiologically confirmed liver mass lesions for the diagnosis of hepatic hydatid disease (HHD) and to compare the …
View article: Incidence, Microbiological Profile, and Impact of Preventive Measures on Central Line-associated Bloodstream Infection in Liver Care Intensive Care Unit
Incidence, Microbiological Profile, and Impact of Preventive Measures on Central Line-associated Bloodstream Infection in Liver Care Intensive Care Unit Open
Khodare A, Kale P, Pindi G, Joy L, Khillan V. Incidence, Microbiological Profile, and Impact of Preventive Measures on Central Line-associated Bloodstream Infection in Liver Care Intensive Care Unit. Indian J Crit Care Med 2020;24(1):17-22.
View article: Elizabethkingia meningoseptica: Waiting to Strike
Elizabethkingia meningoseptica: Waiting to Strike Open
Introduction: The prevalence of nosocomial infection by Elizabethkingia meningoseptica (E. meningoseptica) has increased. It has been found to be associated with outbreaks of neonatal, adult and device related infections with mortality rat…
View article: Diagnostic Utility of Real Time Multiplex PCR for Identification of Atypical Bacterial Respiratory Pathogens
Diagnostic Utility of Real Time Multiplex PCR for Identification of Atypical Bacterial Respiratory Pathogens Open
Introduction: Infections are common in cirrhosis and is the leading cause of progression of liver failure and increased mortality. Non-specific findings on radiology prompt a need for a diagnostic armamentarium targeting both typical as we…
View article: 2047. Study of Molecular epidemiology, risk factor analysis and comparison of diagnostic methods for rapid diagnosis of fungal pneumonia in critically ill cirrhotics
2047. Study of Molecular epidemiology, risk factor analysis and comparison of diagnostic methods for rapid diagnosis of fungal pneumonia in critically ill cirrhotics Open
BACKGROUND: Liver cirrhosis causes immune dysregulation and increased susceptibility to fungal infections. We studiede risk factors, molecular epidemiology and compared the rapid diagnostic methods and biomarkers for fungal pneumonia in cr…
View article: Antimicrobial-Induced Cytopenia and Bone Marrow Hypocellularity in Patients with Cirrhosis
Antimicrobial-Induced Cytopenia and Bone Marrow Hypocellularity in Patients with Cirrhosis Open
There is great variation in cytopenias in cirrhotic patients with same severity and hypersplenism and their causative factors are not clear. Recent studies have highlighted the role of gut microbiome in regulation of constant and emergency…
View article: Resurgence of global opportunistic multidrug-resistant <i>Stenotrophomonas maltophilia</i>
Resurgence of global opportunistic multidrug-resistant <i>Stenotrophomonas maltophilia</i> Open
S. maltophilia was effectively isolated from the hospital environment, with two of hand impression and three of water samples' positive. Patients with respiratory infection had most S. maltophilia isolates. Antibiotic suscept…
View article: The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre
The Prevalence and Profile of Mycobacterial Infections in Liver Diseases from Tertiary Care Hepatobiliary Centre Open
Introduction: There is paucity of data regarding mycobacterial infections in liver diseases. Guidelines do not exist for diagnosis, monitoring of patients and modification of the treatment. Aim: Our aim was to elucidate demographic charact…
View article: A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance
A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance Open
Overall, 25% and 13% of isolates were MDR and multi-azole resistant, respectively. The most common resistance combination was azoles and 5-flucytosine in 14% followed by azoles and amphotericin B in 7% and azoles and echinocandins in 2% of…
View article: Infections in Live Donor Liver Transplant Recipients: A Study of Timeline, Aetiology and Antimicrobial Resistance of Bacterial and Fungal Infections from the Developing World
Infections in Live Donor Liver Transplant Recipients: A Study of Timeline, Aetiology and Antimicrobial Resistance of Bacterial and Fungal Infections from the Developing World Open
Infections are the leading cause of morbidity and mortality in liver transplant (LT) recipients. We studied timeline, spectrum of infection, system involved, and antimicrobial resistance in 64 patients undergoing live donor LT with 6-month…
View article: Bacterial and fungal infections in liver transplant recipients
Bacterial and fungal infections in liver transplant recipients Open
Background: According to the latest WHO data ,Liver disease related deaths in India reached 2.44% of total deaths. The most effective treatment for patients with end-stage liver disease is to undergo liver transplantation. Infectious compl…
View article: <i>Strongyloides stercoralis</i> hyperinfection in patient with autoimmune hepatitis and purpura fulminans
<i>Strongyloides stercoralis</i> hyperinfection in patient with autoimmune hepatitis and purpura fulminans Open
Strongyloidiosis is usually an asymptomatic chronic nematodal disease. The term hyperinfection is used to denote autoinfection, a phenomenon in which the number of worms increases enormously. Development or exacerbation of gastrointestinal…
View article: Catheter associated mycobacteremia: Opening new fronts in infection control
Catheter associated mycobacteremia: Opening new fronts in infection control Open
Mycobacterium fortuitum is a rapidly growing Mycobacterium ubiquitous in nature, known to form biofilms. This property increases its propensity to colonize the in situ central line and makes it a prospective threat for nosocomial infection…
View article: Hemodialysis catheter-related bacteremia caused by Stenotrophomonas maltophilia
Hemodialysis catheter-related bacteremia caused by Stenotrophomonas maltophilia Open