Vikki A. Krysov
YOU?
Author Swipe
View article: The contribution of <i>RBM20</i> truncating variants to human cardiomyopathy
The contribution of <i>RBM20</i> truncating variants to human cardiomyopathy Open
Background Genetic diagnosis has become increasingly important to guide clinical decision making for patients with dilated cardiomyopathy (DCM). Disease-causing (P/LP) missense variants in the gene RBM20 cause a highly penetrant arrhythmog…
<i>Rothia</i>-Associated Meningitis in a Patient With HIV: A Case Report Open
A 47-year-old man with HIV, off antiretroviral therapy for 4 months since losing insurance coverage, presented to the emergency department after he was found unresponsive with blood around the mouth. A seizure was suspected, and cerebrospi…
Overcoming Hesitancy and Barriers to Care with Integration of Telemedicine in a Free Student-run Health Clinic Open
Introduction: Nadezhda Clinic is a free student-run health clinic that provides culturally sensitive primary care services to the underserved Russian-speaking population of the greater Sacramento area. At the onset of the COVID-19 pandemic…
Regional Variation in Cardiovascular Genes Enables a Tractable Genome Editing Strategy Open
BACKGROUND: To realize the potential of genome engineering therapeutics, tractable strategies must be identified that balance personalized therapy with the need for off-the-shelf availability. We hypothesized that regional clustering of pa…
Regional variation in cardiovascular genes enables a tractable genome editing strategy Open
Recent rise in the number and therapeutic potential of genome engineering technologies has generated excitement in cardiovascular genetics. One significant barrier to their implementation is costly and time consuming reagent development fo…
Guide RNA and pegRNA design and preparation v1 Open
This protocol outlines the induction and correction of mutagenesis in HEK293T cells using CRISPR-X and prime editing.