Vikram Saini
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View article: Evaluation of the Modified Early Warning Score (MEWS) in In-Hospital Cardiac Arrest in a Tertiary Healthcare Facility
Evaluation of the Modified Early Warning Score (MEWS) in In-Hospital Cardiac Arrest in a Tertiary Healthcare Facility Open
Background/Objective: In-hospital cardiac arrest has high incidence and poor survival rates, posing a significant healthcare challenge. It is important to intervene in the hours before the cardiac arrest to prevent poor outcomes. The modif…
View article: CCDC 1993716: Experimental Crystal Structure Determination
CCDC 1993716: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2203949: Experimental Crystal Structure Determination
CCDC 2203949: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2203947: Experimental Crystal Structure Determination
CCDC 2203947: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Predictive profiling of gram-negative antibiotics in CagA oncoprotein inactivation: a molecular dynamics simulation approach
Predictive profiling of gram-negative antibiotics in CagA oncoprotein inactivation: a molecular dynamics simulation approach Open
Gastric cancer (GC) is the fifth most prevalent form of cancer worldwide. CagA - positive Helicobacter pylori infects more than 60% of the human population. Moreover, chronic infection of CagA-positive H. pylori can directly …
View article: Predictive profiling of gram-negative antibiotics in CagA oncoprotein inactivation: a molecular dynamics simulation approach
Predictive profiling of gram-negative antibiotics in CagA oncoprotein inactivation: a molecular dynamics simulation approach Open
Gastric cancer (GC) is the fifth most prevalent form of cancer worldwide. CagA - positive Helicobacter pylori infects more than 60% of the human population. Moreover, chronic infection of CagA-positive H. pylori can directly …
View article: Comparative Study of Speed Control of Brushless DC Motor
Comparative Study of Speed Control of Brushless DC Motor Open
This paper presents a comparative study on speed control of brushless DC motors, which has wide applications in electrical vehicles, manufacturing plants, aerospace, etc. Initially, the proportional controller is implemented using the deve…
View article: Selection of Ideal Reference Genes for Gene Expression Analysis in COVID-19 and Mucormycosis
Selection of Ideal Reference Genes for Gene Expression Analysis in COVID-19 and Mucormycosis Open
Gene expression studies are critical to develop new diagnostics, therapeutics, and prognostic modalities. However, accurate determination of expression requires data normalization with a reference gene, whose expression does not vary acros…
View article: Amoxicillin modulates gut microbiota to improve short-term high-fat diet induced pathophysiology in mice
Amoxicillin modulates gut microbiota to improve short-term high-fat diet induced pathophysiology in mice Open
Background A high-fat diet (HFD) induced perturbation of gut microbiota is a major contributory factor to promote the pathophysiology of HFD-associated metabolic syndrome. The HFD could also increase the susceptibility to the microbial inf…
View article: Selection of appropriate reference genes for normalization of qRT-PCR based gene expression analysis in SARS-CoV-2, and Covid-associated Mucormycosis infection
Selection of appropriate reference genes for normalization of qRT-PCR based gene expression analysis in SARS-CoV-2, and Covid-associated Mucormycosis infection Open
Selection of reference genes in quantitative PCR is critical to determine accurate and reliable mRNA expression. Despite this knowledge, not a single study has investigated the expression stability of housekeeping genes to determine their …
View article: Brain abscess associated with Mycoplasma faucium – The initial presentation of pulmonary arteriovenous malformation
Brain abscess associated with Mycoplasma faucium – The initial presentation of pulmonary arteriovenous malformation Open
Brain abscesses represent a pathology with significant morbidity and mortality. An underlying predisposing condition may not be apparent or identifiable in some instances. We present a patient with cerebral abscess who was found to have, p…
View article: A Highly Sensitive and Specific Luminescent Mof Determines ▪No Production and Quantifies Hydrogen Sulfide Mediated Inhibition Of ▪No In Living Cells
A Highly Sensitive and Specific Luminescent Mof Determines ▪No Production and Quantifies Hydrogen Sulfide Mediated Inhibition Of ▪No In Living Cells Open
View article: A Cold Chain-Independent Specimen Collection and Transport Medium Improves Diagnostic Sensitivity and Minimizes Biosafety Challenges of COVID-19 Molecular Diagnosis
A Cold Chain-Independent Specimen Collection and Transport Medium Improves Diagnostic Sensitivity and Minimizes Biosafety Challenges of COVID-19 Molecular Diagnosis Open
Approximately forty-four percent of the global population lives in villages, including 59% in Africa ( https://unhabitat.org/World%20Cities%20Report%202020 ). The fast-evolving nature of SARS-CoV-2 and its extremely contagious nature warra…
View article: Oxalate Alters Cellular Bioenergetics, Redox Homeostasis, Antibacterial Response, and Immune Response in Macrophages
Oxalate Alters Cellular Bioenergetics, Redox Homeostasis, Antibacterial Response, and Immune Response in Macrophages Open
Individuals with calcium oxalate (CaOx) kidney stones can have secondarily infected calculi which may play a role in the development of recurrent urinary tract infection (UTI). Uropathogenic Escherichia coli (UPEC) is the most common causa…
View article: The short term High Fat Diet sparks gut microbiota associated metabolic syndrome pathogenesis and impact of Amoxicillin intervention in mice
The short term High Fat Diet sparks gut microbiota associated metabolic syndrome pathogenesis and impact of Amoxicillin intervention in mice Open
Background Knowledge about alteration in gut microbiota on a high-fat diet (HFD) and common antibiotics for a short period is little known. The study was undertaken to evaluate the changes in the microbiota profile in HFD fed mice followed…
View article: Mycobacterium tuberculosis H2S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility
Mycobacterium tuberculosis H2S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility Open
H2S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H2S has been shown to profoundly alter M. tuberculosis (Mtb) energy metabolism and growth. However, compelling evidence for endogenous production of H2S and its role …
View article: <i>Mycobacterium tuberculosis</i> H<sub>2</sub>S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility
<i>Mycobacterium tuberculosis</i> H<sub>2</sub>S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility Open
H 2 S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H 2 S has been shown to profoundly alter M. tuberculosis ( Mtb ) energy metabolism and growth. However, compelling evidence for endogenous production of H 2 S and i…
View article: CCDC 2052526: Experimental Crystal Structure Determination
CCDC 2052526: Experimental Crystal Structure Determination Open
View article: CCDC 2052523: Experimental Crystal Structure Determination
CCDC 2052523: Experimental Crystal Structure Determination Open
View article: CCDC 2052524: Experimental Crystal Structure Determination
CCDC 2052524: Experimental Crystal Structure Determination Open
View article: CCDC 2052525: Experimental Crystal Structure Determination
CCDC 2052525: Experimental Crystal Structure Determination Open
View article: CCDC 2052527: Experimental Crystal Structure Determination
CCDC 2052527: Experimental Crystal Structure Determination Open
View article: CCDC 2052528: Experimental Crystal Structure Determination
CCDC 2052528: Experimental Crystal Structure Determination Open
View article: Exploring salivary diagnostics in COVID-19: a scoping review and research suggestions
Exploring salivary diagnostics in COVID-19: a scoping review and research suggestions Open
View article: An illustrated step-by-step guide to establish a disinfection facility for reuse of personal protective equipment
An illustrated step-by-step guide to establish a disinfection facility for reuse of personal protective equipment Open
COVID-19 pandemic has created unforeseen public health challenges including the disruption of a steady supply of personal protective equipment (PPE) for health care workers (HCWs). Several approaches have been evaluated for safe disinfecti…
View article: Impact and prognosis of the expression of IFN-α among tuberculosis patients
Impact and prognosis of the expression of IFN-α among tuberculosis patients Open
Mycobacterium tuberculosis (M.tb) infection stimulates the release of cytokines, including interferons (IFNs). IFNs are initiators, regulators, and effectors of innate and adaptive immunity. Accordingly, the expression levels of Type I (α,…
View article: Development of a highly effective low-cost vaporized hydrogen peroxide-based method for disinfection of personal protective equipment for their selective reuse during pandemics
Development of a highly effective low-cost vaporized hydrogen peroxide-based method for disinfection of personal protective equipment for their selective reuse during pandemics Open
Background Personal Protective Equipment (PPE) is required to safely work with biological agents of bacterial (i.e. Mycobacterium tuberculosis) or viral origin (Ebola and SARS). COVID-19 pandemic especially has created unforeseen public he…
View article: Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis Open
Hydrogen sulfide (H 2 S) is involved in numerous pathophysiological processes and shares overlapping functions with CO and • NO. However, the importance of host-derived H 2 S in microbial pathogenesis is unknown. Here we show that Mtb -inf…
View article: Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis
Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis Open
(Cell Reports 25, 1938–1952.e1–e5; November 13, 2018) In the original version of this article, an error in Figure 4E was noted after publication. A version of the upper left panel of Figure 4D was inadvertently used as the upper left panel…
View article: Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis
Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis Open