Viktor R. Drel
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View article: Author Correction: Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype
Author Correction: Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype Open
View article: Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype
Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype Open
Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. Our findings reveal that Mg2+ entry through distinct …
View article: Glycolytic lactate in diabetic kidney disease
Glycolytic lactate in diabetic kidney disease Open
Lactate elevation is a well-characterized biomarker of mitochondrial dysfunction, but its role in diabetic kidney disease (DKD) is not well defined. Urine lactate was measured in patients with type 2 diabetes (T2D) in 3 cohorts (HUNT3, SMA…
View article: Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis
Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis Open
View article: Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity
Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity Open
Reduced kidney AMPK activity is associated with nutrient stress-induced chronic kidney disease (CKD) in male mice. In contrast, female mice resist nutrient stress-induced CKD. The role of kidney AMPK in sex-related organ protection against…
View article: Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity
Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity Open
Reduced kidney AMPK activity is associated with nutrient stress-induced chronic kidney disease (CKD) in male mice. In contrast, female mice resist nutrient stress-induced CKD. The role of kidney AMPK in sex-related organ protection against…
View article: 12-OR: Urine Lactate Is a Disease Biomarker for Diabetic Kidney Disease
12-OR: Urine Lactate Is a Disease Biomarker for Diabetic Kidney Disease Open
As lactate (LA) elevation is associated with mitochondrial dysfunction, we examined the role of LA in diabetic kidney disease (DKD) progression. Urine LA (ULA) was measured in patients with type 2 diabetes (T2D) in three independent cohort…
View article: 332 Role of Kynurenine/Tryptophan Ratio in Kidney-Lung crosstalk in two porcine trauma-induced multi-organ injury models
332 Role of Kynurenine/Tryptophan Ratio in Kidney-Lung crosstalk in two porcine trauma-induced multi-organ injury models Open
OBJECTIVES/GOALS: Multiple Organ Failure, often precipitated by Acute Lung Injury, is a life-threatening condition that causes death in military and civilian life. Furthermore, Acute Kidney Injury is very common, increasing morbidity and m…
View article: Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open
Objective: Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). Research Design and Methods: We performed a case-control st…
View article: Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open
OBJECTIVE Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS We performed a case-control stud…
View article: Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Open
Objective: Understanding mechanisms underlying rapid estimated glomerular filtration rate (eGFR) decline is important to predict and treat kidney disease in type 1 diabetes (T1D). Research Design and Methods: We performed a case-control st…
View article: Temporal Telomere and DNA Damage Responses in the Space Radiation Environment
Temporal Telomere and DNA Damage Responses in the Space Radiation Environment Open
Telomeres, repetitive terminal features of chromosomes essential for maintaining genome integrity, shorten with cell division, lifestyle factors and stresses, and environmental exposures, and so they provide a robust biomarker of health, a…
View article: Temporal Telomere and DNA Damage Responses in the Space Radiation Environment
Temporal Telomere and DNA Damage Responses in the Space Radiation Environment Open
View article: Nephrogenic Systemic Fibrosis Is Mediated by Myeloid C-C Chemokine Receptor 2
Nephrogenic Systemic Fibrosis Is Mediated by Myeloid C-C Chemokine Receptor 2 Open
View article: Centrality of bone marrow in the severity of gadolinium‐based contrast‐induced systemic fibrosis
Centrality of bone marrow in the severity of gadolinium‐based contrast‐induced systemic fibrosis Open
Systemic fibrosis can be induced in humans with gadolinium‐based contrast, and cumulative doses correlate with severity. Bone marrow–derived fibrocytes accumulate in the dermis. Whether target organs liberate chemokines to recruit these fi…
View article: Pathophysiology of gadolinium-associated systemic fibrosis
Pathophysiology of gadolinium-associated systemic fibrosis Open
Systemic fibrosis from gadolinium-based magnetic resonance imaging contrast is a scourge for the afflicted. Although gadolinium-associated systemic fibrosis is a rare condition, the threat of litigation has vastly altered clinical practice…