Viktor Wixler
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View article: The anti-inflammatory and tolerogenic potential of small spleen peptides
The anti-inflammatory and tolerogenic potential of small spleen peptides Open
Maintaining peripheral immune tolerance and preventing harmful autoimmune reactions is a fundamental task of the immune system. However, these essential functions are significantly compromised during autoimmune disorders, creating a major …
View article: Small Spleen Peptides (SSPs) Shape Dendritic Cell Differentiation through Modulation of Extracellular ATP Synthesis Profile
Small Spleen Peptides (SSPs) Shape Dendritic Cell Differentiation through Modulation of Extracellular ATP Synthesis Profile Open
Restoring peripheral immune tolerance is crucial for addressing autoimmune diseases. An ancient mechanism in maintaining the balance between inflammation and tolerance is the ratio of extracellular ATP (exATP) and adenosine. Our previous r…
View article: CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes
CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes Open
Four‐and‐a‐half LIM domains protein 2 (FHL2) is an anti‐hypertrophic adaptor protein that regulates cardiac myocyte signalling and function. Herein, we identified cardiomyopathy‐associated 5 (CMYA5) as a novel FHL2 interaction partner in c…
View article: Phosphorylation of JIP4 at S730 Presents Antiviral Properties against Influenza A Virus Infection
Phosphorylation of JIP4 at S730 Presents Antiviral Properties against Influenza A Virus Infection Open
Influenza A virus (IAV) infection is a world health concern, and current treatment options encounter high rates of resistance. Our group investigates host pathways modified in IAV infection as promising new targets.
View article: Def-6, a Guanine Nucleotide Exchange Factor for Rac1, Interacts with the Skeletal Muscle Integrin Chain α7A and Influences Myoblast Differentiation
Def-6, a Guanine Nucleotide Exchange Factor for Rac1, Interacts with the Skeletal Muscle Integrin Chain α7A and Influences Myoblast Differentiation Open
Integrin alpha7beta1 is the major laminin binding integrin receptor of muscle cells. The alpha7 chain occurs in several splice isoforms, of which alpha7A and alpha7B differ in their intracellular domains only. The fact that the expression …
View article: Phosphorylation of JIP4 at S730 presents anti-viral properties against influenza A virus infection
Phosphorylation of JIP4 at S730 presents anti-viral properties against influenza A virus infection Open
Influenza A virus (IAV) is the causative agent of flu disease that results in annual epidemics and occasional pandemics. IAV alters several signaling pathways of the cellular host response in order to promote its replication. Therefore, ou…
View article: Phosphorylation of Influenza A Virus NS1 at Serine 205 Mediates Its Viral Polymerase-Enhancing Function
Phosphorylation of Influenza A Virus NS1 at Serine 205 Mediates Its Viral Polymerase-Enhancing Function Open
Influenza A viruses (IAVs) still pose a major threat to human health worldwide. As a zoonotic virus, IAV can spontaneously overcome species barriers and even reside in new hosts after efficient adaptation.
View article: Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers
Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers Open
Non-small cell lung cancers (NSCLCs) establish a highly immunosuppressive tumor microenvironment supporting cancer growth. To interfere with cancer-mediated immunosuppression, selective immune-checkpoint inhibitors (ICIs) have been approve…
View article: Spontaneous onset of TNFα‐triggered colonic inflammation depends on functional T lymphocytes, <scp>S100A8</scp>/<scp>A9</scp> alarmins, and <scp>MHC</scp> H‐2 haplotype
Spontaneous onset of TNFα‐triggered colonic inflammation depends on functional T lymphocytes, <span>S100A8</span>/<span>A9</span> alarmins, and <span>MHC</span> H‐2 haplotype Open
Recently, we established a doxycycline‐inducible human tumor necrosis factor alpha (TNFα)‐transgenic mouse line, ihTNFtg. Non‐induced young and elderly mice showed low but constitutive expression of hTNFα due to promoter leakiness. The per…
View article: The role of FHL2 in wound healing and inflammation
The role of FHL2 in wound healing and inflammation Open
The 4‐and‐a‐half LIM domain protein 2 (FHL2) is a multifunctional adaptor protein that can interact with cell surface receptors, cytosolic adaptor and structural proteins, kinases, and nuclear transcription factors. It is involved in numer…
View article: Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation
Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation Open
The four and a half LIM domains protein 2 (Fhl2) is an adaptor protein capable of mediating protein–protein interactions. Here, we report for the first time phenotypic changes in the brain of Fhl2-deficient mice. We showed that Fhl2 is exp…
View article: Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation
Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation Open
Autoimmune diseases, such as psoriasis and arthritis, show a patchy distribution of inflammation despite systemic dysregulation of adaptive immunity. Thus, additional tissue-derived signals, such as danger-associated molecular patterns (DA…
View article: Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages
Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages Open
Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer and demonstrates high resistance to radiation and chemotherapy. These tumors evade immune system detection by promoting an immunosuppressive tumor microenvironment…
View article: Inflammatory Cytokines Stabilize SOXC Transcription Factors to Mediate the Transformation of Fibroblast‐Like Synoviocytes in Arthritic Disease
Inflammatory Cytokines Stabilize SOXC Transcription Factors to Mediate the Transformation of Fibroblast‐Like Synoviocytes in Arthritic Disease Open
Objective Fibroblast‐like synoviocytes (FLS) produce key synovial fluid and tissue components to ensure joint integrity under healthy conditions, whereas they become cancer‐like and aggressively contribute to joint degeneration in inflamma…
View article: Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked
Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked Open
Expression of the influenza A virus (IAV) nonstructural protein (NS1) results in the activation of c-Jun N-terminal kinase (JNK). Both NS1 and JNK are involved in apoptosis induction. To investigate their interrelationship, we stably expre…
View article: Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity
Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity Open
Phosphorylation and dephosphorylation acts as a fundamental molecular switch that alters protein function and thereby regulates many cellular processes. The non-structural protein 1 (NS1) of influenza A virus is an important factor regulat…
View article: In Vitro and In Vivo Antitumor Activity of a Novel Semisynthetic Derivative of Cucurbitacin B
In Vitro and In Vivo Antitumor Activity of a Novel Semisynthetic Derivative of Cucurbitacin B Open
Lung cancer is the most deadly type of cancer in humans, with non-small-cell lung cancer (NSCLC) being the most frequent and aggressive type of lung cancer showing high resistance to radiation and chemotherapy. Despite the outstanding prog…