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View article: Metabolites associated with abnormal glucose metabolism responding to primary care lifestyle intervention
Metabolites associated with abnormal glucose metabolism responding to primary care lifestyle intervention Open
View article: Blueprint of the distinct metabolite profiles of healthy pig heart chambers
Blueprint of the distinct metabolite profiles of healthy pig heart chambers Open
The heart is one of the most studied organs, with physiological processes and disease research. While it is well-established that significant structural and functional differences exist between the chambers, most studies focus on only a si…
View article: Effect of the Roast Level on Lipophilic and Hydrophilic Compounds in Pot and Filter Coffee Beverages
Effect of the Roast Level on Lipophilic and Hydrophilic Compounds in Pot and Filter Coffee Beverages Open
Roast levels may affect the profile and content of phytochemicals in coffee. The composition of potentially bioactive compounds was investigated in pot coffee (PC) and filter coffee (FC) beverages prepared from light, medium, medium-dark, …
View article: Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry
Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry Open
Liquid chromatography‐mass spectrometry (LC–MS) is a powerful technique for the detection and quantification of methylated quaternary ammonium compounds (mQACs), such as acylcarnitines and methylated amino‐acid‐derived (betainized) compoun…
View article: Existing food processing classifications overlook the phytochemical composition of processed plant-based protein-rich foods
Existing food processing classifications overlook the phytochemical composition of processed plant-based protein-rich foods Open
View article: Metabolite variations in faba bean ingredients: Unraveling the links between off-flavors and chemical compounds
Metabolite variations in faba bean ingredients: Unraveling the links between off-flavors and chemical compounds Open
Faba bean ingredients are attracting interest for their suitability in producing protein-rich plant-based foods. However, their sensory characteristics (e.g., bitterness) challenge consumer acceptance. This study explored variations in the…
View article: Metabolic profiles of meconium in preeclamptic and normotensive pregnancies
Metabolic profiles of meconium in preeclamptic and normotensive pregnancies Open
Introduction Preeclampsia (PE) is a common vascular pregnancy disorder affecting maternal and fetal metabolism with severe immediate and long-term consequences in mothers and infants. During pregnancy, metabolites in the maternal circulati…
View article: Anthocyanins as protectors of gut microbiota: mitigating the adverse effects of microplastic-induced disruption
Anthocyanins as protectors of gut microbiota: mitigating the adverse effects of microplastic-induced disruption Open
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
Background: Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promisin…
View article: Author response: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Author response: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promising approach t…
View article: Author response: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Author response: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
View article: Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight
Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight Open
View article: Eight-year diet and physical activity intervention affects serum metabolites during childhood and adolescence: A nonrandomized controlled trial
Eight-year diet and physical activity intervention affects serum metabolites during childhood and adolescence: A nonrandomized controlled trial Open
View article: Reviewer #1 (Public Review): Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder
Reviewer #1 (Public Review): Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to alcohol addiction are not yet fully understood, and in this respect, metabolomics represents a promising approa…
View article: Reviewer #2 (Public Review): Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder
Reviewer #2 (Public Review): Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to alcohol addiction are not yet fully understood, and in this respect, metabolomics represents a promising approa…
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
Background: Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promisin…
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to alcohol addiction are not yet fully understood, and in this respect, metabolomics represents a promising approa…
View article: Eight-year Combined Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood and Adolescence: A Nonrandomized Controlled Trial
Eight-year Combined Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood and Adolescence: A Nonrandomized Controlled Trial Open
Background Molecular mechanisms underlying the beneficial effects of long-term lifestyle interventions on cardiometabolic health during childhood and adolescence remain largely unknown. Such information would provide valuable insights into…
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promising approach t…
View article: Metabolic changes in response to varying whole-grain wheat and rye intake
Metabolic changes in response to varying whole-grain wheat and rye intake Open
View article: Nutritional metabolomics: Recent developments and future needs
Nutritional metabolomics: Recent developments and future needs Open
Metabolomics has rapidly been adopted as one of the key methods in nutrition research. This review focuses on the recent developments and updates in the field, including the analytical methodologies that encompass improved instrument sensi…
View article: Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta
Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta Open
Background The maternal microbiota modulates fetal development, but the mechanisms of these earliest host-microbe interactions are unclear. To investigate the developmental impacts of maternal microbial metabolites, we compared full-term f…
View article: Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression
Associations of altered hepatic gene expression in American lifestyle-induced obesity syndrome diet-fed mice with metabolic changes during NAFLD development and progression Open
Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains poorly understood due to the complex metabolic and inflammatory changes in the liver. This study aimed to elucidate hepatic events related to inflammation and lipid metabolism …
View article: Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition Open
The essential role of gut microbiota in health and disease is well recognized, but the biochemical details that underlie the beneficial impact remain largely undefined. To maintain its stability, microbiota participates in an interactive h…
View article: Metabolite Pattern Derived from <i>Lactiplantibacillus plantarum</i>—Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth
Metabolite Pattern Derived from <i>Lactiplantibacillus plantarum</i>—Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth Open
Scope Fermentation improves many food characteristics using microbes, such as lactic acid bacteria (LAB). Recent studies suggest fermentation may also enhance the health properties, but mechanistic evidence is lacking. The study aims to id…
View article: Microbiota-derived metabolites as drivers of gut–brain communication
Microbiota-derived metabolites as drivers of gut–brain communication Open
Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes transform and metabolize dietary- and host-derived molecules generat…
View article: Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain and placenta
Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain and placenta Open
The maternal microbiota modulates fetal development, but the mechanisms of these earliest host-microbe interactions are unclear. We compared full-term fetuses from germ-free (GF) and normally colonized mouse dams by gene expression profili…
View article: Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease
Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease Open
5-Aminovaleric acid betaine (5-AVAB) is a trimethylated compound associated with the gut microbiota, potentially produced endogenously, and related to the dietary intake of certain foods such as whole grains. 5-AVAB accumulates within the …
View article: Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool
Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool Open
The mechanisms by which exercise benefits patients with non-alcoholic fatty liver disease (NAFLD), the most common liver disease worldwide, remain poorly understood. A non-targeted liquid chromatography-mass spectrometry (LC–MS)-based meta…