Ville Leinonen
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View article: Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk
Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk Open
BACKGROUND: Preeclampsia is associated with increased risk of subsequent maternal cardiovascular diseases (CVD) compared with normotensive pregnancies. We examined whether prolonging the duration between preeclampsia diagnosis and delivery…
View article: The protective <i>PLCG2</i> variants delay Alzheimer’s disease onset age in <i>APOE ε</i>4 carriers
The protective <i>PLCG2</i> variants delay Alzheimer’s disease onset age in <i>APOE ε</i>4 carriers Open
INTRODUCTION We investigated the impact of protective PLCG2 -P522R and PLCG2 -3’UTR variants, and the TREM2 -R62H risk variant on Alzheimer’s disease (AD) onset age in relation to APOE ε4 status. Plasma-based biomarkers of the different va…
View article: Brain Ventricle Morphology Markers in Predicting Shunt Surgery Outcome in Idiopathic Normal-Pressure Hydrocephalus
Brain Ventricle Morphology Markers in Predicting Shunt Surgery Outcome in Idiopathic Normal-Pressure Hydrocephalus Open
Background Idiopathic normal pressure hydrocephalus (iNPH) is characterized by a clinical triad of symptoms: abnormal gait, memory problems, and urinary incontinence. Neuroimaging plays a crucial role in diagnosing iNPH. However, current r…
View article: Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease
Neuroinflammation Markers in Tear Fluid of Mild Alzheimer’s Disease Open
View article: Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype Open
View article: GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy
GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy Open
Cerebrospinal fluid (CSF) amyloid beta (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau181) are well accepted markers of Alzheimer’s disease. We performed a GWAS meta-analysis including 18,948 individuals of European and 416 non-Eu…
View article: APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers′s disease
APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers′s disease Open
Among the more than 90 identified genetic risk loci for late-onset Alzheimer′s disease (AD) and related dementias, the apolipoprotein E gene (APOE) ϵ2/ϵ3/ϵ4 polymorphism remains the longstanding benchmark for genetic disease risk with a co…
View article: Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’
Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’ Open
Background While the temporal profile of amyloid (Aβ) and tau cerebrospinal fluid (CSF) biomarkers along the Alzheimer’s disease (AD) continuum is well-studied, chronological changes of CSF proteins reflecting other disease-relevant proces…
View article: Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab
Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab Open
Objective We have established a comprehensive sample handling protocol designed for the multiscale assessment of epileptogenic tissue. This protocol aims to identify novel therapeutic targets and enhance the diagnosis and stratification of…
View article: Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism
Altered tear fluid protein expression in persons with mild Alzheimer's disease in proteins involved in oxidative stress, protein synthesis, and energy metabolism Open
Background Tear fluid (TF) is a protein-rich solution that reflects pathophysiological changes in Alzheimer's disease (AD). Objective In this study, we examined whether TF proteins were differently expressed in persons with mild AD dementi…
View article: A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease Open
View article: Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus
Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus Open
Background Idiopathic normal pressure hydrocephalus (iNPH) is a common disorder in aging populations. Alzheimer's disease (AD) is a significant comorbidity in iNPH patients, and the presence of AD pathology is associated with worse shuntin…
View article: Outcome After Anterior Cervical Decompression and Fusion—A Nationwide FinSpine Register Study of Independent Predictors of Outcome at 12 Months After Surgery for Degenerative Cervical Spine
Outcome After Anterior Cervical Decompression and Fusion—A Nationwide FinSpine Register Study of Independent Predictors of Outcome at 12 Months After Surgery for Degenerative Cervical Spine Open
Study Design. Longitudinal, nationwide register study. Objective. To identify independent predictors of clinical outcomes at 12 months for patients undergoing primary anterior cervical discectomy and fusion (ACDF) for degenerative cervical…
View article: Microelectrode array scaled for human hippocampal slices
Microelectrode array scaled for human hippocampal slices Open
Temporal lobe epilepsy (TLE) is a prevalent neurological disorder characterized by recurrent seizures originating from the cortex, amygdala and especially hippocampus. While two-thirds of TLE patients achieve seizure control through medica…
View article: Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study
Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study Open
We studied the iNPH-associated CWH43 LOF variants for the first time on a population-scale. Contrary to previously reported findings in smaller cohorts, our study revealed a low prevalence of these variants in the population-scale Finnish …
View article: Association between postoperative thromboembolic and hemorrhagic complications and clinical outcomes after surgery for chronic subdural hematoma in patients with anticoagulation therapy for atrial fibrillation
Association between postoperative thromboembolic and hemorrhagic complications and clinical outcomes after surgery for chronic subdural hematoma in patients with anticoagulation therapy for atrial fibrillation Open
View article: Predictors of Recurrent Opioid and Neuropathic Pain Medication Use After Primary ACDF Surgery for Degenerative Cervical Spine: A Nationwide Finnish Spine Register (FinSpine) Study
Predictors of Recurrent Opioid and Neuropathic Pain Medication Use After Primary ACDF Surgery for Degenerative Cervical Spine: A Nationwide Finnish Spine Register (FinSpine) Study Open
View article: Well-being in pain questionnaire: A novel, reliable, and valid tool for assessment of the personal well-being in individuals with chronic low back pain
Well-being in pain questionnaire: A novel, reliable, and valid tool for assessment of the personal well-being in individuals with chronic low back pain Open
Background Well-being is closely related to health, recovery, and longevity. Chronic musculoskeletal pain (CMP) is a major health challenge in the general population, which can have a negative effect on subjective well-being. The ability t…
View article: Outcome measures after anterior cervical decompression and fusion surgery –non-respondents do not bias the results: A Finnish spine register (FinSpine) study
Outcome measures after anterior cervical decompression and fusion surgery –non-respondents do not bias the results: A Finnish spine register (FinSpine) study Open
Non-respondents do not bias the assessment of outcome measures following ACDF at 12 months, supporting the validity and reliability of national quality registers like FinSpine for clinical research.
View article: Optimizing Feature Selection for Unbalanced Metabolomics Data with A Background Factor: A Comparative Study in Parkinson’s Disease
Optimizing Feature Selection for Unbalanced Metabolomics Data with A Background Factor: A Comparative Study in Parkinson’s Disease Open
Publisher Copyright: © 2024 IEEE.
View article: Ambulatory Care vs Overnight Hospitalization After Anterior Surgery for Cervical Radiculopathy
Ambulatory Care vs Overnight Hospitalization After Anterior Surgery for Cervical Radiculopathy Open
Importance During the past decade, spinal surgical procedures have been increasingly performed on an ambulatory basis, a change in clinical practice supported only by observational evidence thus far. There have been no randomized clinical …
View article: Segment Anything for Dendrites from Electron Microscopy
Segment Anything for Dendrites from Electron Microscopy Open
Segmentation of cellular structures in electron microscopy (EM) images is fundamental to analyzing the morphology of neurons and glial cells in the healthy and diseased brain tissue. Current neuronal segmentation applications are based on …
View article: Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes Open
Background Patients with Alzheimer's disease (AD) frequently present with cerebral amyloid angiopathy (CAA), characterized by the accumulation of beta-amyloid (Aβ) within the cerebral blood vessels, leading to cerebrovascular dysfunction. …
View article: Risk Variants Associated With Normal Pressure Hydrocephalus
Risk Variants Associated With Normal Pressure Hydrocephalus Open
We identified 6 loci significantly associated with NPH in the thus far largest GWAS in chronic hydrocephalus. The genes near the top loci have previously been associated with blood-brain barrier and blood-CSF barrier function and with incr…
View article: Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome
Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome Open
Neuropathologic changes of Alzheimer disease (AD) including Aβ accumulation and neuroinflammation are frequently observed in the cerebral cortex of patients with idiopathic normal pressure hydrocephalus (iNPH). We created an automated anal…
View article: Synapse protein signatures in cerebrospinal fluid and plasma predict cognitive maintenance versus decline in Alzheimer’s disease
Synapse protein signatures in cerebrospinal fluid and plasma predict cognitive maintenance versus decline in Alzheimer’s disease Open
Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous, with ages of symptom onset ranging from age 40-100 years and conversion from mild cognitive impairment to AD dementia taking 2-20 years. Development of bio…
View article: Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry
Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry Open
Background Idiopathic Normal Pressure Hydrocephalus (iNPH) is a chronic condition affecting the elderly. It is characterized by a triad of symptoms and radiological findings. Glaucoma is the leading cause of irreversible blindness worldwid…
View article: Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes Open
Alzheimer’s disease (AD) patients often exhibit cerebral amyloid angiopathy (CAA), i.e beta-amyloid (Aβ) accumulation within cerebral blood vessels causing cerebrovascular dysfunction. Pericytes wrap around vascular capillaries, thus regul…
View article: Monoallelic<i>TYROBP</i>deletion is a novel risk factor for Alzheimer’s disease
Monoallelic<i>TYROBP</i>deletion is a novel risk factor for Alzheimer’s disease Open
Biallelic loss-of-function variants in TYROBP and TREM2 cause autosomal recessive presenile dementia with bone cysts known as Nasu-Hakola disease (NHD, alternatively polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopa…
View article: Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus
Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus Open
Background: The gut microbiome is a complex system within the human gastrointestinal tract. The bacteria play a significant role in human health, and some can promote inflammation and pathologic processes through chemical interactions or m…