Explanipedia

Improving mitochondria-associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and cancer Open

Michal Cagalinec, Mohd Adnan, Silvia Borecká, Geert Bultynck, Vinay Choubey , et al. · 2025

Membrane contact sites harbor a distinct set of proteins with varying biological functions, thereby emerging as hubs for localized signaling nanodomains underlying adequate cell function. Here, we will focus on mitochondria-associated endo…

ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome Open

Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta , et al. · 2024

ER Calcium Depletion as a Key Driver for Impaired ER-to-Mitochondria Calcium Transfer and Mitochondrial Dysfunction in Wolfram Syndrome Open

Mailis Liiv, Annika Vaarmann, Malle Kuum, Ruby Gupta-Blixt, Lucia Janickova , et al. · 2023

Wolfram syndrome (WS) is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in WS involves poor ER Ca²⁺ handling, but how this disturbance leads to the disease is not known. The current study,…

Negative feedback system to maintain cell ROS homeostasis: KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy Open

Akbar Zeb, Vinay Choubey, Ruby Gupta, Vladimir Veksler, Allen Kaasik · 2022

If cellular reactive oxygen species (ROS) production surpasses the intracellular antioxidant capacity, thus altering the ROS homeostasis, the cell needs to eradicate faulty mitochondria responsible for these excessive ROS. We have shown th…

Molecular Mechanisms and Regulation of Mammalian Mitophagy Open

Vinay Choubey, Akbar Zeb, Allen Kaasik · 2021

Mitochondria in the cell are the center for energy production, essential biomolecule synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility enables cells to adapt to the changes in cellular environment a…

A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy Open

Akbar Zeb, Vinay Choubey, Ruby Gupta, Malle Kuum, Dzhamilja Safiulina , et al. · 2021

Withdrawal: Activation of autophagic flux against xenoestrogen bisphenol-A-Induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of rapamycin (mTOR) pathways. Open

Swati Agarwal, Shashi Kant Tiwari, Brashket Seth, Anuradha Yadav, Anshuman Singh , et al. · 2020

VOLUME 290 (2015) PAGES 21163–21184 This article has been withdrawn by the authors. Portions of the LC3 immunoblot in Fig 2B overlap with Fig 3A. The Control and BPA (40μg/kg) images in Fig 2F are duplicates. Considering these issues, the …

Withdrawal: Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal Open

Pallab Maity, Samik Bindu, Vinay Choubey, Athar Alam, Kalyan Mitra , et al. · 2019

VOLUME 283 (2008) PAGES 14391–14401 This article has been withdrawn by the authors. The images of 2 and 4 h after NSAID exposure without lansoprazole from Table 1 were reused in Fig. 7 of Pal, C., et al. (2012) J. Biol. Chem. 287, 3495–350…

Mitochondrial transport proteins RHOT1 and RHOT2 serve as docking sites for PRKN-mediated mitophagy Open

Dzhamilja Safiulina, Malle Kuum, Vinay Choubey, Miriam A. Hickey, Allen Kaasik · 2019

The Parkinson disease-associated proteins PINK1 and PRKN coordinate the ubiquitination of mitochondrial outer membrane proteins to tag them either for degradation or for autophagic clearance of the mitochondrion. The proteins include the m…

Miro proteins prime mitochondria for Parkin translocation and mitophagy Open

Dzhamilja Safiulina, Malle Kuum, Vinay Choubey, Nana Gogichaishvili, Joanna Liiv , et al. · 2018

Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome Open

Michal Cagalinec, Mailis Liiv, Zuzana Hodurova, Miriam A. Hickey, Annika Vaarmann , et al. · 2016

Deficiency of the protein Wolfram syndrome 1 (WFS1) is associated with multiple neurological and psychiatric abnormalities similar to those observed in pathologies showing alterations in mitochondrial dynamics. The aim of this study was to…

Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway Open

Shashi Kant Tiwari, Brashket Seth, Swati Agarwal, Anuradha Yadav, Madhumita Karmakar , et al. · 2015

Activation of Autophagic Flux against Xenoestrogen Bisphenol-A-induced Hippocampal Neurodegeneration via AMP kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Pathways Open

Swati Agarwal, Shashi Kant Tiwari, Brashket Seth, Anuradha Yadav, Anshuman Singh , et al. · 2015

Wolfram syndrome 1: from ER stress to impaired mitochondrial dynamics and neuronal development Open

Mailis Liiv, Michal Cagalinec, Zuzana Hodurova, Annika Vaarmann, Merle Mandel , et al. · 2015

Mitochondrial biogenesis is rate limiting-factor for axonal growth Open

Merle Mandel, Annika Vaarmann, Akbar Zeb, Przemyslaw Warȩski, Joanna Liiv , et al. · 2015

SpringerPlus 2015, 4(Suppl 1):L1 MicroRNAs (miRNAs) are short, 22-25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3'-untranslated region (3'-UTR) of coding mRNA targets, interrupting trans…

Miro1 overexpression protects against α-synuclein-induced mitochondrial loss in neuronal culture Open

Dzhamilja Safiulina, Vinay Choubey, Miriam A. Hickey, Allen Kaasik · 2015

Vinay Choubey YOU? Author Swipe