Vinay Thohan
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View article: Conservatively-managed large left ventricular pseudoaneurysm with progressive symptom resolution: a case report
Conservatively-managed large left ventricular pseudoaneurysm with progressive symptom resolution: a case report Open
A left ventricular pseudoaneurysm typically occurs as a result of myocardial infarction, blunt chest trauma, or cardiac surgery (typically coronary artery bypass grafting or mitral valve replacement). Pseudoaneurysms form due to left ventr…
View article: Non-ischemic cardiomyopathy after rituximab treatment for mucous membrane pemphigoid: a case report
Non-ischemic cardiomyopathy after rituximab treatment for mucous membrane pemphigoid: a case report Open
We report a rare case of non-ischemic cardiomyopathy in a 62-year-old female with mucous membrane pemphigoid following rituximab therapy. The patient presented with dyspnea and chest pain, and cardiac evaluation-including transthoracic ech…
View article: Genetic insights into non-ischemic arrhythmogenic cardiomyopathy: a case report of desmoplakin mutation
Genetic insights into non-ischemic arrhythmogenic cardiomyopathy: a case report of desmoplakin mutation Open
We aim to describe a unique case of a desmoplakin gene mutation with refractory ventricular arrhythmia and cardiomyopathy. We describe a 29-year-old man hospitalized for chest pain and cardiomyopathy, who subsequently developed ventricular…
View article: Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial
Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial Open
BACKGROUND: An interatrial shunt may provide an autoregulatory mechanism to decrease left atrial pressure and improve heart failure (HF) symptoms and prognosis. METHODS: Patients with symptomatic HF with any left ventricular ejection fract…
View article: Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human
Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human Open
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute to both diseases, suggesting a common underlying pathop…
View article: Use of a Pulmonary Artery Pressure Sensor to Manage Patients With Left Ventricular Assist Devices
Use of a Pulmonary Artery Pressure Sensor to Manage Patients With Left Ventricular Assist Devices Open
Background: Hemodynamic-guided management with a pulmonary artery pressure sensor (CardioMEMS) is effective in reducing heart failure hospitalization in patients with chronic heart failure. This study aims to determine the feasibility and …
View article: Echocardiographic assessment of radial right ventricular function in heart transplant recipients
Echocardiographic assessment of radial right ventricular function in heart transplant recipients Open
Aims Right ventricular (RV) allograft dysfunction is present in half of all heart transplant (HT) recipients. Non‐invasive assessment of RV function in the setting of rejection is not well described. We outline an echocardiographic techniq…
View article: Impact of a <scp>pharmacist‐inclusive post‐discharge</scp> clinic on outcomes in heart failure patients with reduced ejection fraction: Rates of hospital readmission, emergency department visits, or death
Impact of a <span>pharmacist‐inclusive post‐discharge</span> clinic on outcomes in heart failure patients with reduced ejection fraction: Rates of hospital readmission, emergency department visits, or death Open
Introduction Heart failure hospitalization is a hallmark of disease progression associated with increased morbidity and mortality. Benefits of multidisciplinary clinics have been established in the care of heart failure patients and can be…
View article: A principal components analysis of factors associated with successful implementation of an LVAD decision support tool
A principal components analysis of factors associated with successful implementation of an LVAD decision support tool Open
Background A central goal among researchers and policy makers seeking to implement clinical interventions is to identify key facilitators and barriers that contribute to implementation success. Despite calls from a number of scholars, empi…
View article: A Principal Components Analysis of Factors Associated with Successful Implementation of an LVAD Decision Support Tool
A Principal Components Analysis of Factors Associated with Successful Implementation of an LVAD Decision Support Tool Open
BackgroundA central goal among researchers and policy makers seeking to implement clinical interventions is to identify key facilitators and barriers that contribute to implementation success. Despite calls from a number of scholars, empir…
View article: A Principal Components Analysis of Factors Associated with Successful Implementation of an LVAD Decision Support Tool
A Principal Components Analysis of Factors Associated with Successful Implementation of an LVAD Decision Support Tool Open
Background: A central goal among researchers and policy makers seeking to implement clinical interventions is to identify key facilitators and barriers that contribute to implementation success. Despite calls from a number of scholars, emp…
View article: Double Jeopardy Cardiomyopathy Requiring Heart Transplant: Hydroxychloroquine and Rheumatoid Arthritis
Double Jeopardy Cardiomyopathy Requiring Heart Transplant: Hydroxychloroquine and Rheumatoid Arthritis Open
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View article: Left ventricular assist systems and infection-related outcomes: A comprehensive analysis of the MOMENTUM 3 trial
Left ventricular assist systems and infection-related outcomes: A comprehensive analysis of the MOMENTUM 3 trial Open
Infection is the most common adverse effect in patients implanted with contemporary continuous-flow LVADs, with most such events unrelated to the pump or its peripheral components. Whether chronic mechanical circulatory devices confer an i…
View article: Strong muscles, weak heart: testosterone‐induced cardiomyopathy
Strong muscles, weak heart: testosterone‐induced cardiomyopathy Open
Exogenous anabolic androgen steroid use is associated with adverse cardiovascular outcomes. A 53‐year‐old bodybuilder presented with 3 months of exertional dyspnoea. Physical examination showed tachycardia and pan‐systolic murmur; an echoc…
View article: Benefits of Neurohormonal Therapy in Patients With Continuous-Flow Left Ventricular Assist Devices
Benefits of Neurohormonal Therapy in Patients With Continuous-Flow Left Ventricular Assist Devices Open
Left ventricular assist devices (LVADs) have dramatically improved short-term outcomes among patients with advanced heart failure. While neurohormonal blockade (NHB) is the cornerstone of treatment for patients with heart failure with redu…
View article: Healthcare Resource Use and Cost Implications in the MOMENTUM 3 Long-Term Outcome Study
Healthcare Resource Use and Cost Implications in the MOMENTUM 3 Long-Term Outcome Study Open
Background: The MOMENTUM 3 trial compares the centrifugal HeartMate 3 (HM3) with the axial HeartMate II (HMII) continuous-flow left ventricular assist system in patients with advanced heart failure, irrespective of the intended goal of the…
View article: Xenoreactive antibodies and latent fibrin formation in VAD and cardiac transplant recipients can confound the detection and measurement of anti-AT1R antibodies
Xenoreactive antibodies and latent fibrin formation in VAD and cardiac transplant recipients can confound the detection and measurement of anti-AT1R antibodies Open
Autoantibodies to the angiotensin II type 1 receptor (AT1R) are thought to be important in antibody-mediated rejection (AMR), especially in the absence of anti-HLA antibodies. We used a variety of methods to examine the specificity of a co…
View article: An Incidental Finding of AL‑associated Amyloidosis Presenting as Gastric Ulcers
An Incidental Finding of AL‑associated Amyloidosis Presenting as Gastric Ulcers Open
Gastrointestinal tract amyloidosis has been reported in rare instances and related symptoms are usually nonspecific to the disease process. We present a patient who initially had melena on anticoagulation and endoscopy revealed a bleeding …
View article: Mechanisms of Left Ventricular Thrombus Formation in Heart Failure With Reduced Ejection Fraction: Novel Insights From Two-Dimensional Speckle Tracking Echocardiography
Mechanisms of Left Ventricular Thrombus Formation in Heart Failure With Reduced Ejection Fraction: Novel Insights From Two-Dimensional Speckle Tracking Echocardiography Open
Background: Patients suffering from heart failure with reduced ejection fraction (HFrEF) are at increased risk for left ventricular (LV) thrombus and subsequent thromboembolism, yet anticoagulation is not routinely recommended for left ven…
View article: Does Left Ventricular Assist Device Implantation Affect Driving Patterns in Patients With End-Stage Heart Failure?
Does Left Ventricular Assist Device Implantation Affect Driving Patterns in Patients With End-Stage Heart Failure? Open
Background
In 2012, the Canadian Society of Cardiology indicated that patients supported with left ventricular assist device (LVAD) may drive a private vehicle 2 months after implantation, provided they are deemed clinically stable. Obje…
View article: Does Left Ventricular Assist Device Implantation Affect Driving Patterns in Patients With End-Stage Heart Failure?
Does Left Ventricular Assist Device Implantation Affect Driving Patterns in Patients With End-Stage Heart Failure? Open
Background In 2012, the Canadian Society of Cardiology indicated that patients supported with left ventricular assist device (LVAD) may drive a private vehicle 2 months after implantation, provided they are deemed clinically stable. Object…
View article: Favorable Outcomes of LVAD as Bridge to Simultaneous Heart-Kidney Transplantation
Favorable Outcomes of LVAD as Bridge to Simultaneous Heart-Kidney Transplantation Open
Background
Chronic kidney disease (CKD) is an established risk factor for incident cardiovascular disease and progression of heart failure disease state, and is associated with decreased survival after left ventricular assist device…
View article: The Association Between Doppler Measures of Cardiac Function and Outcomes in Patients With Left Ventricular Ejection Fraction ≤ 40% Undergoing Noncardiovascular Surgeries
The Association Between Doppler Measures of Cardiac Function and Outcomes in Patients With Left Ventricular Ejection Fraction ≤ 40% Undergoing Noncardiovascular Surgeries Open
Background: Preoperative risk assessments of individuals who undergo major noncardiac surgery have focused on ischemic heart disease. Information on how to assess the noncardiac surgical risks for patients with depressed cardiac function, …