Sharad Kumar
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View article: NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury
NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury Open
The membrane pore-forming gasdermin (GSDM) proteins are essential executors of pyroptosis. The GSDM family members GSDMD and GSDME can also target mitochondrial membranes, driving apoptosis. Here, we identify the ubiquitin ligase NEDD4L as…
View article: Trends, Challenges, and Opportunities in the Current Landscape of India’s Wool Sector: A Review
Trends, Challenges, and Opportunities in the Current Landscape of India’s Wool Sector: A Review Open
The wool sector in India plays a vital role in the livelihoods of millions of sheep-rearing households, contributing approximately 1.8% to global wool production. India ranks among the largest wool-producing countries globally, yet its mar…
View article: Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice
Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice Open
NEDD4-2, a ubiquitin ligase, regulates a number of ion channels and transporters by promoting their ubiquitination, internalisation and degradation, thereby affecting many signalling and physiological outcomes. Loss of this gene in mice re…
View article: NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis
NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis Open
Successful testis development relies on the coordinated differentiation and assembly of various cell types to establish both endocrine and reproductive functions. The ubiquitin ligase NEDD4 has emerged as a key player in murine testis deve…
View article: Morphological and Biochemical Basis of Resistance in Pulses to the Spotted Pod Borer <i>Maruca vitrata</i>
Morphological and Biochemical Basis of Resistance in Pulses to the Spotted Pod Borer <i>Maruca vitrata</i> Open
Spotted pod borer Maruca vitrata is one of the serious insect on the legumes crop, which causes damage to the crop mainly at the reproductive phase. A study conducted for their preference among four pulses crops namely, pigeanpea, green gr…
View article: Validation of the 5th edition of the World Health Organization and International Consensus Classification guidelines for TP53-mutated myeloid neoplasm in an independent international cohort
Validation of the 5th edition of the World Health Organization and International Consensus Classification guidelines for TP53-mutated myeloid neoplasm in an independent international cohort Open
The World Health Organization (WHO-5) and International Consensus Classification (ICC) acknowledge the poor prognosis of TP53 -mutated ( TP53 mut ) myeloid neoplasm (MN). However, there are substantial differences between the two classific…
View article: Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster
Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster Open
Autophagy-dependent cell death (ADCD) is a context-specific form of programmed cell death that plays an important role in development and homeostasis. During Drosophila metamorphosis, hormonal cues modulate growth and other signalling casc…
View article: Evidence-based risk stratification of myeloid neoplasms harboring <i>TP53</i> mutations
Evidence-based risk stratification of myeloid neoplasms harboring <i>TP53</i> mutations Open
This retrospective analysis aimed to provide evidence-based risk stratification of TP53-mutated (TP53mut) myeloid neoplasms (MNs). Of 580 MNs harboring TP53mut with variant allele frequency (VAF) ≥2%, 219 (37.8%), 194 (33.4%), 92 (15.9%), …
View article: NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis
NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis Open
Successful testis development relies on the coordinated differentiation and assembly of various cell types to establish both endocrine and reproductive functions. The ubiquitin ligase NEDD4 has emerged as a key player in murine testis deve…
View article: Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition
Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition Open
Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression of the human papilloma virus (HPV) oncogenes and loss of retinoblastoma (RB) protein function ha…
View article: Prevalence of bacterial isolates causing surgical site infection with an emphasis on their biofilm forming capacity
Prevalence of bacterial isolates causing surgical site infection with an emphasis on their biofilm forming capacity Open
Background: Biofilm forming bacteria are the cause of many chronic and recurrent infections and are believed to be main factor for the development of non-healing wounds by inducing chronic inflammation.Therefore, early detection ofbiofilm …
View article: Caspase-2 protects against ferroptotic cell death
Caspase-2 protects against ferroptotic cell death Open
Caspase-2, one of the most evolutionarily conserved members of the caspase family, is an important regulator of the cellular response to oxidative stress. Given that ferroptosis is suppressed by antioxidant defense pathways, such as that i…
View article: Understanding Developmental Cell Death Using Drosophila as a Model System
Understanding Developmental Cell Death Using Drosophila as a Model System Open
Cell death plays an essential function in organismal development, wellbeing, and ageing. Many types of cell deaths have been described in the past 30 years. Among these, apoptosis remains the most conserved type of cell death in metazoans …
View article: The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy
The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy Open
Autophagy, the process of elimination of cellular components by lysosomal degradation, is essential for animal development and homeostasis. Using the autophagy-dependent Drosophila larval midgut degradation model we identified an autophagy…
View article: Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling
Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling Open
Retromer prevents the destruction of numerous receptors by recycling them from endosomes to the trans-Golgi network or plasma membrane. This enables retromer to fine-tune the activity of many signaling pathways in parallel. However, the me…
View article: Caspase-2 protects against ferroptotic cell death
Caspase-2 protects against ferroptotic cell death Open
Caspase-2, one of the most evolutionarily conserved member of the caspase family, is an important regulator of the cellular response to oxidative stress. Given that ferroptosis is suppressed by antioxidant defense pathways, such as that in…
View article: A polynomial of degree five representing the selling price of an inventory of deteriorating items with a linear degradation rate, constant holding cost, and demand-dependent selling price
A polynomial of degree five representing the selling price of an inventory of deteriorating items with a linear degradation rate, constant holding cost, and demand-dependent selling price Open
The study suggests a deterministic inventory model as opposed to a probabilistic one. With just odd powers considered, the model's demand rate is a degree five polynomial of the selling price. The keeping expense is assumed to stay constan…
View article: Receptor Recycling by Retromer
Receptor Recycling by Retromer Open
The highly conserved retromer complex controls the fate of hundreds of receptors that pass through the endolysosomal system and is a central regulatory node for diverse metabolic programs. More than 20 years ago, retromer was discovered as…
View article: Joint effect of selling price and promotional efforts on retailer’s inventory control policy with trade credit, time-dependent holding cost, and partial backlogging under inflation
Joint effect of selling price and promotional efforts on retailer’s inventory control policy with trade credit, time-dependent holding cost, and partial backlogging under inflation Open
Technology improvements in the retail industry influence the buying behaviours of customers. In the retail industry, it has been observed that the selling price of goods and promotional efforts influence a customer’s choice. In the retail …
View article: Ganglion Impar Block: A Magic Bullet to Fix Idiopathic Coccygodynia
Ganglion Impar Block: A Magic Bullet to Fix Idiopathic Coccygodynia Open
Coccygodynia (coccydynia) is a painful condition of the perineum in the region of the tailbone or coccyx, aggravated by sitting on hard surfaces. It is frequently associated with injuries to the coccyx following direct trauma. Nevertheless…
View article: Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling
Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling Open
Retromer prevents the destruction of numerous receptors by recycling them from endosomes to the trans-Golgi network or plasma membrane. This enables retromer to fine-tune the activity of many signaling pathways in parallel. However, the me…
View article: Sustainable fuzzy inventory model for deteriorating item with partial backordering along with social and environmental responsibility under the effect of learning
Sustainable fuzzy inventory model for deteriorating item with partial backordering along with social and environmental responsibility under the effect of learning Open
Mitigating carbon emissions and waste, along with economic objectives, are the major concerns for businesses and industries today. Current studies have underlined the requirement to shift the company from entrepreneur to ecopreneur with th…