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View article: Three-dimensional H&E histopathology powered by deep learning-assisted multimodal nonlinear microscopy
Three-dimensional H&E histopathology powered by deep learning-assisted multimodal nonlinear microscopy Open
The diagnostic and prognostic potential of histopathology can be significantly enhanced with three-dimensional (3D) imaging. Histopathology relies on the gold-standard 2D inspection of hematoxylin and eosin (H&E)-stained tissue sections wi…
View article: A review on the role of microRNA-340 and curcumin in apoptosis and metastasis in colorectal cancer
A review on the role of microRNA-340 and curcumin in apoptosis and metastasis in colorectal cancer Open
MicroRNAs (miRNAs), which are small non-coding RNA molecules, play a crucial role in regulating gene expression following transcription. They are essential for cellular functions like proliferation, metastasis, apoptosis, and differentiati…
View article: IMUNOTERAPIJOS SUKELTAS SKYDLIAUKĖS FUNKCIJOS SUTRIKIMAS, GYDANT AKIŲ MELANOMĄ: KLINIKINIS ATVEJIS
IMUNOTERAPIJOS SUKELTAS SKYDLIAUKĖS FUNKCIJOS SUTRIKIMAS, GYDANT AKIŲ MELANOMĄ: KLINIKINIS ATVEJIS Open
Pristatomas 57 metų moters, sergančios gyslainės melanoma, atvejis. Dėl gydymo imunoterapija pacientei sutriko skydliaukės funkcija. Nustačius metastazes kepenyse, atlikta abliacija, o dėl ligos progresavimo skirtas gydymas dakarbazinu. …
View article: Correction: Sequential treatment of metastatic renal cell carcinoma patients after first-line vascular endothelial growth factor targeted therapy in a real-world setting: epidemiologic, noninterventional, retrospective–prospective cohort multicentre study
Correction: Sequential treatment of metastatic renal cell carcinoma patients after first-line vascular endothelial growth factor targeted therapy in a real-world setting: epidemiologic, noninterventional, retrospective–prospective cohort multicentre study Open
View article: A Prospective Observational Study Evaluating Predictive and Prognostic Biomarkers in Metastatic Melanoma Undergoing Immunotherapy (BIOMELKID)
A Prospective Observational Study Evaluating Predictive and Prognostic Biomarkers in Metastatic Melanoma Undergoing Immunotherapy (BIOMELKID) Open
View article: 90P Meta-analysis of hypophysitis incidence in melanoma patients treated with immune checkpoint inhibitors
90P Meta-analysis of hypophysitis incidence in melanoma patients treated with immune checkpoint inhibitors Open
View article: 160P Oral DNA vaccination targeting personalised neoantigens in immune checkpoint-inhibitor treated solid tumor patients: Interim results
160P Oral DNA vaccination targeting personalised neoantigens in immune checkpoint-inhibitor treated solid tumor patients: Interim results Open
View article: Immune Checkpoint Blockade in Melanoma – Earlier is Better?
Immune Checkpoint Blockade in Melanoma – Earlier is Better? Open
Administering checkpoint inhibition before surgery, known as neoadjuvant therapy, shows promise in treating bulky yet resectable melanomas, and researchers are investigating its potential in various other cancer types. This approach boasts…
View article: Harnessing ctDNA in Advanced Melanoma: A Promising Tool for Informed Clinical Decisions
Harnessing ctDNA in Advanced Melanoma: A Promising Tool for Informed Clinical Decisions Open
Cutaneous melanoma, an aggressive malignancy, has undergone significant transformation in clinical management with the introduction of immune checkpoint inhibitors (ICIs) and targeted therapies. Current monitoring methods, such as imaging …
View article: Atezolizumab Retains Cellular Binding to Programmed Death Ligand 1 Following Aerosolization<i>via</i>Mesh Nebulizer
Atezolizumab Retains Cellular Binding to Programmed Death Ligand 1 Following Aerosolization<i>via</i>Mesh Nebulizer Open
VM nebulization does not obliterate the functionality of the drug atezolizumab. The integrity of a nebulized form can be rapidly assessed by FTIR and Raman spectrometry.
View article: Sequential treatment of metastatic renal cell carcinoma patients after first-line vascular endothelial growth factor targeted therapy in a real-world setting: epidemiologic, noninterventional, retrospective–prospective cohort multicentre study
Sequential treatment of metastatic renal cell carcinoma patients after first-line vascular endothelial growth factor targeted therapy in a real-world setting: epidemiologic, noninterventional, retrospective–prospective cohort multicentre study Open
Purpose The purpose of our study was to determine whether data on the clinical effectiveness of second-line therapy collected in a real-world setting provide additional valuable information on the optimal sequence of metastatic renal cell …
View article: Sunitinib in patients with favorable and intermediate risk metastatic renal cell carcinoma – Lithuanian National Cancer Institute experience
Sunitinib in patients with favorable and intermediate risk metastatic renal cell carcinoma – Lithuanian National Cancer Institute experience Open
Introduction and Objectives Sunitinib, according to the European Society for Medical Oncology (ESMO) and National Comprehensive Cancer Network (NCCN) recommendations, is one of the recommended regimens for favorable and intermediate risk m…
View article: Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in Lithuania: an analysis of national cancer registration data by gender and anatomical site, 1991–2015
Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in Lithuania: an analysis of national cancer registration data by gender and anatomical site, 1991–2015 Open
In our study, we found higher incidence rates of skin melanoma in females. Melanoma was more commonly diagnosed in the trunk of males and limbs of females, with the highest mortality increase in trunk melanoma in both genders.
View article: The Impact of the COVID-19 Pandemic on Cancer Patient’s Management—Lithuanian Cancer Center Experience
The Impact of the COVID-19 Pandemic on Cancer Patient’s Management—Lithuanian Cancer Center Experience Open
The pandemic spread of the COVID-19 virus significantly affected daily life, but the highest pressure was piled on the health care system. Our aim was to evaluate an impact of COVID-19 pandemic management measures on cancer services at the…
View article: Do the benefits of being a smoker hint at the existence of PD-1/PD-L1 sensitizers for patients on single-agent immunotherapy?
Do the benefits of being a smoker hint at the existence of PD-1/PD-L1 sensitizers for patients on single-agent immunotherapy? Open
Multiple studies demonstrate significantly better therapeutics outcomes in smokers as compared with never smokers when single-agent immunotherapy is applied. Non-smoker patients usually need a combination of chemoimmunotherapy to achieve c…
View article: Retrospective cohort study of androgen deprivation therapy and the risk of diabetes in men with prostate cancer in Lithuania
Retrospective cohort study of androgen deprivation therapy and the risk of diabetes in men with prostate cancer in Lithuania Open
Objectives To examine the risk of type 2 diabetes in patients with prostate cancer and its association with androgen deprivation therapy (ADT). Design and participants We performed a retrospective cohort study of patients diagnosed with pr…
View article: Trends in Incidence and Mortality of Skin Melanoma in Lithuania 1991–2015
Trends in Incidence and Mortality of Skin Melanoma in Lithuania 1991–2015 Open
Background. We aimed to investigate age-specific and sex-specific incidence trends of melanoma in Lithuania from 1991 to 2015. Methods. Analysis was based on data from the population-based Lithuanian Cancer Registry database for 1991–2015,…
View article: Reproductive Factors and Breast Cancer Risk in Lithuanian Women: A Population-Based Cohort Study
Reproductive Factors and Breast Cancer Risk in Lithuanian Women: A Population-Based Cohort Study Open
Background. Although the relationship between reproductive factors and breast cancer is internationally proved, reliable data on former USSR countries are scarce. This study examines the association of parity, age at the first childbirth, …
View article: Sunitinib in patients with metastatic renal cell carcinoma of intermediate and high risk groups – Lithuanian National Cancer Institute retrospective analysis
Sunitinib in patients with metastatic renal cell carcinoma of intermediate and high risk groups – Lithuanian National Cancer Institute retrospective analysis Open
View article: Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study
Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study Open
Emerging data indicates that melanoma may be linked to prostate cancer. We evaluated if the incidence of melanoma was associated with subsequent risk of prostate cancer (PC). We extracted data from the Lithuanian cancer registry from 1993 …
View article: Survival and time interval from surgery to the start of chemotherapy for patients with stage II and III colon cancer
Survival and time interval from surgery to the start of chemotherapy for patients with stage II and III colon cancer Open
Background. Usually adjuvant chemotherapy is started within 12 weeks of surgery, but the evidence on the commencing time is lacking. Our aim was to investigate the association of initiating post-surgery treatment within six weeks vs. six t…
View article: Breast Cancer Screening Program in Lithuania: Interval Cancers and Program Sensitivity After 7 Years of Mammography Screening
Breast Cancer Screening Program in Lithuania: Interval Cancers and Program Sensitivity After 7 Years of Mammography Screening Open
Objective: Analysis of interval cancers is critical in determining the sensitivity of screening and represents an objective measure of the quality of mammography screening program (MSP). Methods: Period analyzed: from 2006 to 2012. The rat…
View article: Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial
Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial Open
View article: Diagnostic accuracy of procalcitonin, interleukin-6 and interleukin-8 for predicting Gram-negative bacteremia in febrile neutropenia patients with acute lymphoblastic leukemia
Diagnostic accuracy of procalcitonin, interleukin-6 and interleukin-8 for predicting Gram-negative bacteremia in febrile neutropenia patients with acute lymphoblastic leukemia Open
Background. Currently available biomarkers are not specific and sensitive enough for early detection of bacterial infection in patients with cancer who have febrile neutropenia. The objective of this study was to assess diagnostic accuracy…