Vincent A. Magnotta
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View article: QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding a biosignature, Protocol for a cross-sectional diagnostic study (Preprint)
QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding a biosignature, Protocol for a cross-sectional diagnostic study (Preprint) Open
BACKGROUND Myofascial pain remains an underdiagnosed contributor to musculoskeletal pain conditions, including plantar heel pain, the most common source of foot pain. The current standard for diagnosing myofascial pain is a clinical exam …
View article: Efficacy of Diet on Quality of life in Multiple Sclerosis (EDQ-MS): a study protocol for a randomized controlled clinical trial
Efficacy of Diet on Quality of life in Multiple Sclerosis (EDQ-MS): a study protocol for a randomized controlled clinical trial Open
Background The primary objective of this study is to evaluate the efficacy of two dietary interventions, time-restricted olive oil-based (TROO) ketogenic and modified Paleolithic elimination (MPE), compared to usual care control group rece…
View article: Central Nervous System Iron Content in Pediatric CKD
Central Nervous System Iron Content in Pediatric CKD Open
View article: Feasibility and accuracy of the ASERT digital questionnaire in mood tracking for a longitudinal research study on bipolar disorder
Feasibility and accuracy of the ASERT digital questionnaire in mood tracking for a longitudinal research study on bipolar disorder Open
View article: A dose-finding study shows terazosin enhanced energy metabolism in neurologically healthy adults
A dose-finding study shows terazosin enhanced energy metabolism in neurologically healthy adults Open
Background Parkinson's disease (PD) is a common neurodegenerative disease lacking treatments that modify progressive neuron loss. Terazosin (TZ) increases activity of the glycolytic enzyme phosphoglycerate kinase 1 and could potentially be…
View article: Accelerating 3D radial MPnRAGE using a self‐supervised deep factor model
Accelerating 3D radial MPnRAGE using a self‐supervised deep factor model Open
Purpose To develop a self‐supervised and memory‐efficient deep learning image reconstruction method for 4D non‐Cartesian MRI with high resolution and a large parametric dimension. Methods The deep factor model (DFM) represents a parametric…
View article: HIV and Low Omega-3 Levels May Heighten Hippocampal Volume Differences Between Men and Women With Substance Use
HIV and Low Omega-3 Levels May Heighten Hippocampal Volume Differences Between Men and Women With Substance Use Open
View article: SNP-Associated Differential Methylation in<i>ARHGEF38:</i>Insights into Genetic-Epigenetic Interactions
SNP-Associated Differential Methylation in<i>ARHGEF38:</i>Insights into Genetic-Epigenetic Interactions Open
Objective Associations have been seen between suicidal behavior and differential DNA methylation of certain genes, with one study showing significant hypomethylation of ARHGEF38 in postmortem brain samples from individuals with bipolar dis…
View article: Characteristics of people with bipolar disorder I with and without auditory verbal hallucinations
Characteristics of people with bipolar disorder I with and without auditory verbal hallucinations Open
View article: Decreased Cerebral Atp in Pre-Motor Manifest Huntington's Disease: A Pilot Study
Decreased Cerebral Atp in Pre-Motor Manifest Huntington's Disease: A Pilot Study Open
View article: A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study
A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study Open
Background Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current st…
View article: ASSOCIATIONS BETWEEN SLEEP HYGIENE INDEX SCORE AND WHITE MATTER MICROSTRUCTURE
ASSOCIATIONS BETWEEN SLEEP HYGIENE INDEX SCORE AND WHITE MATTER MICROSTRUCTURE Open
Sleep complaints are common among older adults. Sleep hygiene refers to practices that promote adequate sleep and may represent an interventional target for improving sleep quality. Individuals with Alzheimer’s disease often exhibit white …
View article: Associations Between Circadian Timing and White Matter Microstructure
Associations Between Circadian Timing and White Matter Microstructure Open
Background Individuals with Alzheimer’s disease often exhibit white matter microstructure degenerations observable through diffusion tensor imaging (DTI). The circadian system regulates sleep and wake cycles. As people age, sleep and wake …
View article: PyAMARES, an Open-Source Python Library for Fitting Magnetic Resonance Spectroscopy Data
PyAMARES, an Open-Source Python Library for Fitting Magnetic Resonance Spectroscopy Data Open
Background/Objectives: Magnetic resonance spectroscopy (MRS) is a valuable tool for studying metabolic processes in vivo. While numerous quantification methods exist, the advanced method for accurate, robust, and efficient spectral fitting…
View article: Safety Clearance and Artifact Testing of a Nitinol Breast Biopsy Clip in an Ultra-High Resolution (7 Tesla) Magnetic Resonance Imaging Environment
Safety Clearance and Artifact Testing of a Nitinol Breast Biopsy Clip in an Ultra-High Resolution (7 Tesla) Magnetic Resonance Imaging Environment Open
Background The lack of safety clearance of several metallic breast biopsy clips in 7 Tesla (T) poses a significant hurdle to using advanced magnetic resonance imaging (MRI) techniques in clinical management or cancer research. Aims This ar…
View article: Mutant Huntingtin Drives Development of an Advantageous Brain Early in Life: Evidence in Support of Antagonistic Pleiotropy
Mutant Huntingtin Drives Development of an Advantageous Brain Early in Life: Evidence in Support of Antagonistic Pleiotropy Open
Objective Huntington's disease (HD) is a neurodegenerative disease caused by a triplet repeat expansion within the gene huntingtin ( HTT ). Antagonistic pleiotropy is a theory of aging that posits that some genes, facilitating individual f…
View article: Patterns of Immune Dysregulation in Bipolar Disorder
Patterns of Immune Dysregulation in Bipolar Disorder Open
Background Bipolar disorder is a debilitating mood disorder associated with a high risk of suicide and characterized by immune dysregulation. In this study, we used a multi-faceted approach to better distinguish the pattern of dysregulatio…
View article: An Improved Postprocessing Method to Mitigate the Macroscopic Cross-Slice B0 Field Effect on R2* Measurements in the Mouse Brain at 7T
An Improved Postprocessing Method to Mitigate the Macroscopic Cross-Slice B0 Field Effect on R2* Measurements in the Mouse Brain at 7T Open
The MR transverse relaxation rate, R2*, has been widely used to detect iron and myelin content in tissue. However, it is also sensitive to macroscopic B0 inhomogeneities. One approach to correct for the B0 effect is to fit gradient-echo si…
View article: A pilot dose-finding study of Terazosin in humans
A pilot dose-finding study of Terazosin in humans Open
Background Parkinson’s disease (PD) is a prevalent neurodegenerative disorder where progressive neuron loss is driven by impaired brain bioenergetics, particularly mitochondrial dysfunction and disrupted cellular respiration. Terazosin (TZ…
View article: Structural Changes in Brain White Matter Tracts Associated With Overactive Bladder Revealed by Diffusion Tensor Magnetic Resonance Imaging: Findings From a Symptoms of Lower Urinary Tract Dysfunction Research Network Cross-Sectional Case-Control Study
Structural Changes in Brain White Matter Tracts Associated With Overactive Bladder Revealed by Diffusion Tensor Magnetic Resonance Imaging: Findings From a Symptoms of Lower Urinary Tract Dysfunction Research Network Cross-Sectional Case-Control Study Open
ClinicalTrials.gov: NCT02485808.
View article: Investigating the relationship between DNA methylation, genetic variation, and suicide attempt in bipolar disorder
Investigating the relationship between DNA methylation, genetic variation, and suicide attempt in bipolar disorder Open
Individuals with bipolar disorder are at increased risk for suicide, and this can be influenced by a range of biological, clinical, and environmental risk factors. Biological components associated with suicide include DNA modifications tha…
View article: Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder Open
Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA methylation patterns may serve as possible biomarkers of SA. We conducted epigenome-wide association studies (EWAS) of blood DNA methylation associate…
View article: Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Study Representativeness Table
View article: Figure S2 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S2 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Predictive power of T2* in patients receiving standard-of-care therapy.
View article: Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Study Representativeness Table
View article: Figure S5 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S5 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
U251 cells have lower basal levels of labile iron.
View article: Figure S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S1 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
T2* relaxation in GBM and normal tissue.
View article: Figure S3 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S3 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Test, re-test study to determine inter- and intra-session variability of T2* mapping in vivo.
View article: Data from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Data from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
Purpose:Pharmacologic ascorbate (P-AscH−) is hypothesized to be an iron (Fe)-dependent tumor-specific adjuvant to chemoradiation in treating glioblastoma (GBM). This study determined the efficacy of combining P-AscH− …
View article: Figure S7 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
Figure S7 from Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open
P-AscH- stimulates the release of iron as Fe2+ from ferritin.