Explanipedia

Monitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients with Multiple Myeloma Open

Charissa Wijnands, Peter Karel, Jolein Gloerich, Gad Armony, Anastasia Tzasta , et al. · 2025

Background/Objectives: Multiple Myeloma (MM) is a hematologic malignancy caused by clonally expanded plasma cells that produce a monoclonal immunoglobulin (M-protein), a personalized biomarker. Recently, we developed an ultra-sensitive mas…

An automated workflow based on data independent acquisition for practical and high-throughput personalized assay development and minimal residual disease monitoring in multiple myeloma patients Open

Charissa Wijnands, Gad Armony, Somayya Noori, Jolein Gloerich, Vincent Bonifay , et al. · 2024

Objectives Minimal residual disease (MRD) status in multiple myeloma (MM) is an important prognostic biomarker. Personalized blood-based targeted mass spectrometry detecting M-proteins (MS-MRD) was shown to provide a sensitive and minimall…

M-protein diagnostics in multiple myeloma patients using ultra-sensitive targeted mass spectrometry and an off-the-shelf calibrator Open

Charissa Wijnands, Pieter Langerhorst, Somayya Noori, Jenneke J. Keizer-Garritsen, Hans J. C. T. Wessels , et al. · 2023

Objectives Minimal residual disease status in multiple myeloma is an important prognostic biomarker. Recently, personalized blood-based targeted mass spectrometry (MS-MRD) was shown to provide a sensitive and minimally invasive alternative…

Author Correction: Property space mapping of Pseudomonas aeruginosa permeability to small molecules Open

Inga V. Leus, Jon W. Weeks, Vincent Bonifay, Yue Shen, Liang Yang , et al. · 2023

P10 AN ULTRA-SENSITIVE METHOD FOR SEQUENCING AND MONITORING OF M-PROTEIN IN PERIPHERAL BLOOD (M-INSIGHT) Open

Vincent Bonifay, Victor Vimard, Somayya Noori, Charissa Wijnands, Cyrille Touzeau , et al. · 2023

With the improvement of therapy (monoclonal antibody, CAR-T), detection of minimal residual disease (MRD) and early restart of therapy is of high importance to manage multiple myeloma disease (MM). Most sensitive MRD assays to date are bas…

B04 IMPLEMENTING M-PROTEIN DIAGNOSTICS IN MULTIPLE MYELOMA PATIENTS USING ULTRA-SENSITIVE TARGETED MASS SPECTROMETRY DATA AND AN OFF-THE-SHELF CALIBRATOR Open

Charissa Wijnands, Pieter Langerhorst, Somayya Noori, Jolein Gloerich, Vincent Bonifay , et al. · 2023

Introduction: Minimal residual disease (MRD) detection in Multiple Myeloma (MM) patients currently relies on bone marrow samples. These tests provide important information, but are invasive and not suitable for frequent monitoring. However…

Dynamic monitoring of myeloma minimal residual disease with targeted mass spectrometry Open

Somayya Noori, Charissa Wijnands, Pieter Langerhorst, Vincent Bonifay, Christoph Stingl , et al. · 2023

Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics Open

Inga V. Leus, Justyna Adamiak, Brinda Chandar, Vincent Bonifay, Shibin Zhao , et al. · 2023

Gram-negative bacteria are notoriously more resistant to antibiotics than Gram-positive bacteria, primarily due to the presence of the outer membrane and a plethora of active efflux pumps. However, the potency of antibiotics also varies dr…

Property space mapping of Pseudomonas aeruginosa permeability to small molecules Open

Inga V. Leus, Jon W. Weeks, Vincent Bonifay, Yue Shen, Liang Yang , et al. · 2022

Two membrane cell envelopes act as selective permeability barriers in Gram-negative bacteria, protecting cells against antibiotics and other small molecules. Significant efforts are being directed toward understanding how small molecules p…

A selective antibiotic for Lyme disease Open

Nadja Leimer, Xiaoqian Wu, Yu Imai, Madeleine Morrissette, Norman Pitt , et al. · 2021

Loss of RND-Type Multidrug Efflux Pumps Triggers Iron Starvation and Lipid A Modifications in Pseudomonas aeruginosa Open

Justyna Adamiak, Varsha Jhawar, Vincent Bonifay, Courtney E. Chandler, Inga V. Leus , et al. · 2021

Transporters belonging to the r esistance- n odulation- d ivision (RND) superfamily of proteins are invariably present in the genomes of Gram-negative bacteria and are largely responsible for the intrinsic antibiotic resistance of these or…

Defining new chemical space for drug penetration into Gram-negative bacteria Open

Shibin Zhao, Justyna Adamiak, Vincent Bonifay, Jitender Mehla, Helen I. Zgurskaya , et al. · 2020

Erratum for Leus et al., “Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii” Open

Inga V. Leus, Jon W. Weeks, Vincent Bonifay, Lauren A. Smith, Sophie Richardson , et al. · 2020

2 from bottom, AbΔ3 columns: For CF, "0.01" and "0.01" should read "8 -16" and "Not determined," respectively; for TRI, "0.78 -1.56" and "0.78" should read "0.01" and "0.01

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors Open

Yangxiong Li, Jessi J. Gardner, Katherine R. Fortney, Inga V. Leus, Vincent Bonifay , et al. · 2019

Metabolomic study of human tissue and urine in clear cell renal carcinoma by LC-HRMS and PLS-DA Open

Joanna Nizioł, Vincent Bonifay, Krzysztof Ossoliński, Tadeusz Ossoliński, Anna Ossolińska , et al. · 2018

Renal cell carcinoma (RCC) is the most prevalent and lethal malignancy of the kidney. Despite all the efforts made, no tissue biomarker is currently used in the clinical management of patients with kidney cancer. A search for possible biom…

Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii Open

Inga V. Leus, Jon W. Weeks, Vincent Bonifay, Lauren A. Smith, Sophie Richardson , et al. · 2018

Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the resistance-nod…

Untargeted Metabolomics Approach in Halophiles: Understanding the Biodeterioration Process of Building Materials Open

Justyna Adamiak, Vincent Bonifay, Anna Otlewska, Jan Sunner, Iwona B. Beech , et al. · 2017

The aim of the study was to explore the halophile metabolome in building materials using untargeted metabolomics which allows for broad metabolome coverage. For this reason, we used high-performance liquid chromatography interfaced to high…

Metabolomic and Metagenomic Analysis of Two Crude Oil Production Pipelines Experiencing Differential Rates of Corrosion Open

Vincent Bonifay, Boris Wawrik, Jan Sunner, Emily C. Snodgrass, Egemen Aydın , et al. · 2017

Corrosion processes in two North Sea oil production pipelines were studied by analyzing pig envelope samples via metagenomic and metabolomic techniques. Both production systems have similar physico-chemical properties and injection waters …

Metabolomic and high-throughput sequencing analysis—modern approach for the assessment of biodeterioration of materials from historic buildings Open

Beata Gutarowska, Sukriye Celikkol-Aydin, Vincent Bonifay, Anna Otlewska, Egemen Aydın , et al. · 2015

Preservation of cultural heritage is of paramount importance worldwide. Microbial colonization of construction materials, such as wood, brick, mortar, and stone in historic buildings can lead to severe deterioration. The aim of the present…

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