Vin‐Cent Wu
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View article: Real-world trends in glucagon-like peptide-1 receptor agonists prescribing in acute kidney disease: a global federated-network study of dialysis-requiring acute kidney injury survivors
Real-world trends in glucagon-like peptide-1 receptor agonists prescribing in acute kidney disease: a global federated-network study of dialysis-requiring acute kidney injury survivors Open
View article: Saline and N-acetylcysteine-based strategies and other approaches to prevent the risk of CA-AKI: a meta-analysis
Saline and N-acetylcysteine-based strategies and other approaches to prevent the risk of CA-AKI: a meta-analysis Open
Background While hydration is currently the most evidence-supported strategy for preventing contrast-associated acute kidney injury (CA-AKI) in patients undergoing cardiovascular angiography, the potential benefits of combining a saline an…
View article: Finerenone versus spironolactone in patients with chronic kidney disease and type 2 diabetes: a target trial emulation
Finerenone versus spironolactone in patients with chronic kidney disease and type 2 diabetes: a target trial emulation Open
View article: SUN-224 Interrogating the Distinction Between Low-Renin Hypertension and Primary Aldosteronism Using Angiotensin Converting Enzyme Inhibition
SUN-224 Interrogating the Distinction Between Low-Renin Hypertension and Primary Aldosteronism Using Angiotensin Converting Enzyme Inhibition Open
Disclosure: C. Tsai: None. J.M. Brown: None. S.P. Salle: None. A.J. Newman: None. V. Wu: None. Y. Lin: None. A. Vaidya: None. Background: Primary aldosteronism (PA) is a form of low-renin hypertension (LRH) characterized by inappropriate a…
View article: #1592 Impact of sodium-glucose cotransporter-2 inhibitors on outcomes in patients with type 1 diabetes with acute kidney disease
#1592 Impact of sodium-glucose cotransporter-2 inhibitors on outcomes in patients with type 1 diabetes with acute kidney disease Open
Background and Aims Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) have shown significant benefits in improving cardiovascular and kidney outcomes, primarily in patients with type 2 diabetes (T2D) and acute kidney disease (AKD). This…
View article: Immune checkpoint inhibitors-associated acute kidney injury: a systematic review and meta-analysis of incidence, kidney recovery, and recurrent risk
Immune checkpoint inhibitors-associated acute kidney injury: a systematic review and meta-analysis of incidence, kidney recovery, and recurrent risk Open
View article: Discontinuation versus continuation of renin–angiotensin system inhibitors in chronic kidney disease stage 3–5 patients: a systematic review and meta-analysis
Discontinuation versus continuation of renin–angiotensin system inhibitors in chronic kidney disease stage 3–5 patients: a systematic review and meta-analysis Open
Background Renin-angiotensin system inhibitors (RASi), comprising angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB) are known for cardio- and renoprotection. However, there is uncertainty regarding t…
View article: Comparison of Acute Kidney Disease Staging by Estimated Glomerular Filtration Rate and by Serum Creatinine Ratio in Patients With Dialysis-requiring Acute Kidney Injury: A National Cohort Study From Taiwan
Comparison of Acute Kidney Disease Staging by Estimated Glomerular Filtration Rate and by Serum Creatinine Ratio in Patients With Dialysis-requiring Acute Kidney Injury: A National Cohort Study From Taiwan Open
We conclude that the AKDeGFR staging system performs better than the AKDsCr staging system in patients with acute kidney injury requiring dialysis regarding all-cause mortality and kidney recovery. Future investigatio…
View article: Universal Screening for Primary Aldosteronism in Hypertensive Patients: A 2025 Taipei Positional Paper
Universal Screening for Primary Aldosteronism in Hypertensive Patients: A 2025 Taipei Positional Paper Open
View article: Incidence of pregnancy-associated acute kidney injury in low- and middle-income countries: a meta-analysis
Incidence of pregnancy-associated acute kidney injury in low- and middle-income countries: a meta-analysis Open
Pregnancy-associated acute kidney injury is a significant maternal health concern in low- and middle-income countries. By providing more resources to prevent the common etiologies and expand the availability of antenatal care, its deleteri…
View article: Liquid Chromatography-Tandem Mass Spectrometry Outperforms Radioimmunoassay in Guiding Surgical Decisions Based on Adrenal Venous Sampling in Primary Aldosteronism
Liquid Chromatography-Tandem Mass Spectrometry Outperforms Radioimmunoassay in Guiding Surgical Decisions Based on Adrenal Venous Sampling in Primary Aldosteronism Open
LC-MS/MS outperformed RIA in identifying unilateral disease, resulting in higher rates of complete clinical success in adrenalectomy patients when surgical decisions were based on LC-MS/MS lateralization results.
View article: Incident obstructive sleep apnea in patients with primary aldosteronism following COVID-19 infection: a health global federated network analysis
Incident obstructive sleep apnea in patients with primary aldosteronism following COVID-19 infection: a health global federated network analysis Open
Background: In the context of the COVID-19 pandemic, there is growing concern about the virus’s effects on individuals with existing endocrine disorders such as primary aldosteronism (PA). Objectives: This study explores the potential rela…
View article: Proteomic signatures to detect unilateral primary aldosteronism in hypertensive patients
Proteomic signatures to detect unilateral primary aldosteronism in hypertensive patients Open
Context Primary aldosteronism (PA) is a major cause of hypertension and cardiovascular disease; however, diagnosing PA remains challenging. Objective We investigated whether deep proteomic analyses could be used to diagnose unilateral PA i…
View article: Trajectories of urea‑to‑creatinine ratio and risk of clinical outcomes in survivors of acute kidney disease: a population-based study
Trajectories of urea‑to‑creatinine ratio and risk of clinical outcomes in survivors of acute kidney disease: a population-based study Open
Background The urea-to-creatinine ratio (UCR) serves as a common metric for assessing dehydration, catabolism, excessive protein intake and impaired kidney perfusion. However, the performance of UCR in patients with acute kidney disease (A…
View article: Non‐Inferiority of Subcutaneous Efepoetin Alfa Compared to Methoxy Polyethylene Glycol‐Epoetin Beta in Stage 3 or 4 <scp>CKD</scp> Patients: Insights From a Phase 3 Trial
Non‐Inferiority of Subcutaneous Efepoetin Alfa Compared to Methoxy Polyethylene Glycol‐Epoetin Beta in Stage 3 or 4 <span>CKD</span> Patients: Insights From a Phase 3 Trial Open
Aim Efepoetin alfa, a novel long‐acting erythropoietin (EPO)‐hybrid Fc fusion protein, represents a promising erythropoiesis‐stimulating agent (ESA) for addressing anaemia in chronic kidney disease (CKD) patients. This Phase 3 trial was to…
View article: Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis Open
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes metabolic constraints on cancer cells. The meta…
View article: Association of Angiotensin Receptor-Neprilysin Inhibitors Use and Better Cardiorenal Outcomes in Patients With Heart Failure and Acute Kidney Disease
Association of Angiotensin Receptor-Neprilysin Inhibitors Use and Better Cardiorenal Outcomes in Patients With Heart Failure and Acute Kidney Disease Open
In HF patients with AKD, ARNi was associated with reduced all-cause mortality, MAKE, and readmission risks compared to ACEi, particularly with concurrent mineralocorticoids, diuretics, or beta-blockers. Future research is necessary to furt…
View article: Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis Open
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes metabolic constraints on cancer cells. The meta…
View article: Cardio-kidney outcomes for combined versus monotherapy with finerenone or SGLT2 inhibitors in patients with CKD
Cardio-kidney outcomes for combined versus monotherapy with finerenone or SGLT2 inhibitors in patients with CKD Open
Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and finerenone each improve kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD). This study compares the association between combined therapy versus…
View article: Renal replacement therapy modalities and techniques in intensive care units: An international survey
Renal replacement therapy modalities and techniques in intensive care units: An international survey Open
This international survey underscores the large diversity in RRT practices wordlwide, as well as heterogeneity in beliefs and preferences among intensivists. These data highlight the need for robust comparative trials to identify the optim…
View article: Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis Open
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes metabolic constraints on cancer cells. The meta…
View article: Potential benefits of GLP-1 receptor agonist in dialysis patients with type 2 diabetes: the need for comprehensive pharmacokinetic and hemodialysis analyses
Potential benefits of GLP-1 receptor agonist in dialysis patients with type 2 diabetes: the need for comprehensive pharmacokinetic and hemodialysis analyses Open
View article: Speculating suitability of partial adrenalectomy for lateralized primary aldosteronism: With emphasis on partial and complete success as optimistic outcomes
Speculating suitability of partial adrenalectomy for lateralized primary aldosteronism: With emphasis on partial and complete success as optimistic outcomes Open
View article: Unilateral Primary Aldosteronism Lacking <i>KCNJ5</i> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus
Unilateral Primary Aldosteronism Lacking <i>KCNJ5</i> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus Open
The association between KCNJ5 mutations and the risk of developing new-onset diabetes mellitus (NODM) in patients with unilateral primary aldosteronism (uPA) remains underexplored. To investigate this association, we conducted a longitudin…
View article: <b>Unilateral Primary Aldosteronism Lacking</b><b><i> KCNJ5</i></b><b> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus</b>
<b>Unilateral Primary Aldosteronism Lacking</b><b><i> KCNJ5</i></b><b> Somatic Mutations is Associated with an Elevated Risk of New-Onset Diabetes Mellitus</b> Open
The association between KCNJ5 mutations and the risk of developing new-onset diabetes mellitus (NODM) in patients with unilateral primary aldosteronism (uPA) remains underexplored. To investigate this association, we conducted a longitudin…
View article: C-terminal FGF-23 production coupling with aldosterone via FAM20C and predicting cardiovascular events in primary aldosteronism
C-terminal FGF-23 production coupling with aldosterone via FAM20C and predicting cardiovascular events in primary aldosteronism Open
This study examined the involvement of fibroblast growth factor-23 (FGF-23) in primary aldosteronism (PA), a condition characterized by elevated aldosterone levels and hypertension. We recruited patients with unilateral PA (uPA) and observ…
View article: Quality indicators and clinical outcomes: the role of care quality in nondiabetic chronic kidney disease management
Quality indicators and clinical outcomes: the role of care quality in nondiabetic chronic kidney disease management Open
Quality indicators (QIs) are essential for evaluating healthcare quality, but their validation for nondiabetic chronic kidney disease (CKD) populations is limited. We aimed to assess the association between QIs and outcomes in nondiabetic …
View article: Association of glucagon-like peptide-1 receptor agonists with cardiovascular and kidney outcomes in type 2 diabetic kidney transplant recipients
Association of glucagon-like peptide-1 receptor agonists with cardiovascular and kidney outcomes in type 2 diabetic kidney transplant recipients Open
View article: Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis
Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis Open
Background The object of this study was to investigate the incidence rate of major adverse cardiovascular event (MACE) among patients with primary aldosteronism (PA) after adrenalectomy or mineralocorticoid receptor antagonist (MRA) treatm…
View article: Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study
Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study Open
Objectives Immune checkpoint inhibitors (ICPi) have significantly improved survival for patients with advanced cancers. However, the occurrence of ICPi-associated acute kidney injury (AKI) and its clinical impact remains unclear. This stud…