Charles Vincent
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View article: Patient-reported harm from NHS treatment or care, or the lack of access to care: a cross-sectional survey of general population prevalence, impact and responses
Patient-reported harm from NHS treatment or care, or the lack of access to care: a cross-sectional survey of general population prevalence, impact and responses Open
Objectives The aim of this article is to provide an estimate of the proportion of the general public reporting healthcare-related harm in Great Britain, its location, impact, responses post-harm and desired reactions from healthcare provid…
View article: Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT
Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT Open
Background Transitions from hospital to home are a risky time for older people (aged 75 years and older). Unplanned and often avoidable hospital re-admissions are therefore high in this group. This research aimed to understand if increased…
View article: The Dutch gender-neutral pronoun die: more accepted for generic than for specific reference
The Dutch gender-neutral pronoun die: more accepted for generic than for specific reference Open
Research on English singular they and Swedish hen indicates that gender-neutral pronouns for specific (nonbinary) reference are less accepted than for generic reference. This raises the question whether this greater acceptance of the gener…
View article: Requirements for effective investigation and learning after suicide: the views of persons with lived experience and professionals
Requirements for effective investigation and learning after suicide: the views of persons with lived experience and professionals Open
Objective This study aims to provide a deeper understanding of what persons with lived experience and professionals with experience of patient safety, suicide research, and investigations consider to be most important in investigations of …
View article: Systems analysis of clinical incidents: development of a new edition of the London Protocol
Systems analysis of clinical incidents: development of a new edition of the London Protocol Open
The investigation of incidents and accidents, together with subsequent reflection and action, is an essential component of safety management in every safety-critical industry, including healthcare. A number of formal methods of incident an…
View article: Investigators are human too: outcome bias and perceptions of individual culpability in patient safety incident investigations
Investigators are human too: outcome bias and perceptions of individual culpability in patient safety incident investigations Open
Background Healthcare patient safety investigations inappropriately focus on individual culpability and the target of recommendations is often on the behaviours of individuals, rather than addressing latent failures of the system. The aim …
View article: A road map for the operationalization of resilience in healthcare - A mixed method study
A road map for the operationalization of resilience in healthcare - A mixed method study Open
View article: Strategies for adapting under pressure: an interview study in intensive care units
Strategies for adapting under pressure: an interview study in intensive care units Open
Background Healthcare systems are operating under substantial pressures. Clinicians and managers are constantly having to make adaptations, which are typically improvised, highly variable and not coordinated across teams. This study aimed …
View article: The safety of early phase clinical trials: Bridging the gap between governance and practice
The safety of early phase clinical trials: Bridging the gap between governance and practice Open
Clinical trials are governed by an extensive set of laws, regulations, guidance and ethical frameworks aimed at safeguarding human health and managing the risks of medical research. These documents cover every phase of clinical research an…
View article: A service-user digital intervention to collect real-time safety information on acute, adult mental health wards: the WardSonar mixed-methods study
A service-user digital intervention to collect real-time safety information on acute, adult mental health wards: the WardSonar mixed-methods study Open
Background Acute inpatient mental health services report high levels of safety incidents. The application of patient safety theory has been sparse, particularly concerning interventions that proactively seek patient perspectives. Objective…
View article: Adaptive strategies used by surgical teams under pressure: an interview study among senior healthcare professionals in four major hospitals in the United Kingdom
Adaptive strategies used by surgical teams under pressure: an interview study among senior healthcare professionals in four major hospitals in the United Kingdom Open
Background Healthcare systems are operating under substantial pressures, and often simply cannot provide the standard of care they aspire to within the available resources. Organisations, managers, and individual clinicians make constant a…
View article: Making a career in patient safety: How I got hooked
Making a career in patient safety: How I got hooked Open
View article: The quality of care delivered to residents in long-term care in Australia: an indicator-based review of resident records (CareTrack Aged study)
The quality of care delivered to residents in long-term care in Australia: an indicator-based review of resident records (CareTrack Aged study) Open
Background This study estimated the prevalence of evidence-based care received by a population-based sample of Australian residents in long-term care (LTC) aged ≥ 65 years in 2021, measured by adherence to clinical practice guideline (CPG)…
View article: The impact of a new approach to family safeguarding in social care: Initial findings from an analysis of routine data
The impact of a new approach to family safeguarding in social care: Initial findings from an analysis of routine data Open
Child safeguarding services intervene when a child is at risk of serious emotional or physical harm. Oxfordshire County Council is implementing a new approach to child safeguarding (Family Solutions Plus [FSP]) with a greater focus on whol…
View article: Greed, Exploitation and Identification with Capitalism
Greed, Exploitation and Identification with Capitalism Open
Greed The association of Jews with money, and the depiction of Jews as a uniquely greedy and rapacious people, is one of the oldest of antisemitic myths. Writings, speeches and imagery portraying Jews as grasping, avaricious and miserly, e…
View article: Health services under pressure: a scoping review and development of a taxonomy of adaptive strategies
Health services under pressure: a scoping review and development of a taxonomy of adaptive strategies Open
Objective The objective of this review was to develop a taxonomy of pressures experienced by health services and an accompanying taxonomy of strategies for adapting in response to these pressures. The taxonomies were developed from a revie…
View article: Exploring the “Black Box” of Recommendation Generation in Local Health Care Incident Investigations: A Scoping Review
Exploring the “Black Box” of Recommendation Generation in Local Health Care Incident Investigations: A Scoping Review Open
Background Incident investigation remains a cornerstone of patient safety management and improvement, with recommendations meant to drive action and improvement. There is little empirical evidence about how—in real-world hospital settings—…
View article: Data from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Data from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Subpopulations of cancer stem–like cells (CSC) are thought to drive tumor progression and posttreatment recurrence in multiple solid tumors. However, the mechanisms that maintain stable proportions of self-renewing CSC within heterogeneous…
View article: Supplemental Figure S6 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S6 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Annexin II expression is not enriched in cancer stem cell populations.
View article: Supplemental Figure S3 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S3 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Progastrin regulates the self-renewal of ALDHhigh colorectal CSCs.
View article: Supplemental Figure S2 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S2 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Progastrin inhibition decreases colonosphere incidence, CSC frequency and ALDHhigh cell proportion in vitro.
View article: Supplemental Methods from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Methods from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Description of additional methods and procedures used in the study.
View article: Supplemental Figure S1 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S1 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
ALDHhigh CRC cells display CSC characteristics and elevated progastrin expression.
View article: Supplemental Figure S5 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S5 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Promotion of a glycolytic profile by progastrin is essential for the self-renewal ability of ALDHhigh cells.
View article: Supplemental Figure S4 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S4 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
shRNA-mediated down regulation of progastrin in vitro and in vivo.
View article: Supplemental Figure S4 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S4 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
shRNA-mediated down regulation of progastrin in vitro and in vivo.
View article: Supplemental Figure S3 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S3 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Progastrin regulates the self-renewal of ALDHhigh colorectal CSCs.
View article: Supplemental Figure S1 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S1 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
ALDHhigh CRC cells display CSC characteristics and elevated progastrin expression.
View article: Supplemental Figure S2 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure S2 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Progastrin inhibition decreases colonosphere incidence, CSC frequency and ALDHhigh cell proportion in vitro.
View article: Supplemental Figure Legends from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Supplemental Figure Legends from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells Open
Legend for Supplemental Figures S1-S6.