Vincent Gagné
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View article: Extrachromosomal microDNA Signature as Candidate Biomarker in Pediatric Acute Lymphoblastic Leukemia
Extrachromosomal microDNA Signature as Candidate Biomarker in Pediatric Acute Lymphoblastic Leukemia Open
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Despite improved therapies, refractory and relapsed ALL remain the leading cause of cancer-related mortality in children. There is a need for accessible biomarkers for…
View article: Roles of HLA-DRB107 :01 and HLA-B15 :01 in the risk of acute Graft Versus Host Disease in pediatric patients undergoing HSCT
Roles of HLA-DRB107 :01 and HLA-B15 :01 in the risk of acute Graft Versus Host Disease in pediatric patients undergoing HSCT Open
Graft Versus Host Disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT). Previous studies suggest that genes coding for different components of the immune system, like human leukocyte antigen …
View article: Uncovering possible silent acquired long <scp>QT</scp> syndrome using exercise stress testing in long‐term pediatric acute lymphoblastic leukemia survivors
Uncovering possible silent acquired long <span>QT</span> syndrome using exercise stress testing in long‐term pediatric acute lymphoblastic leukemia survivors Open
An example of chemotherapy‐induced cardiotoxicity in cancer survivors is acquired long QT syndrome (aLQTS), which may cause serious yet preventable life‐threatening consequences. Our objective was to identify and characterize childhood acu…
View article: Data from <i>Bim</i> Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia
Data from <i>Bim</i> Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia Open
Purpose: Corticosteroids induce apoptosis in the malignant lymphoid cells and are critical component of combination therapy for acute lymphoblastic leukemia (ALL). Several genome-wide microarray studies showed major implication of proapopt…
View article: Supplementary Table 1 and 2 from <i>Bim</i> Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia
Supplementary Table 1 and 2 from <i>Bim</i> Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia Open
Supplementary Table 1 and 2 - PDF file 68K, Supplementary Table 1. Identity of tagSNPs, details of PCR and ASO hybridization Supplementary Table 2. Identity of polymorphisms genotyped only in controls
View article: Supplementary Table 1 from Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia
Supplementary Table 1 from Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia Open
PDF file - 80K, Polymorphisms in ATF5, ASNS and ASS1 genes analyzed in the relation to ASNase related complications.
View article: Supplementary Table 1 from Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia
Supplementary Table 1 from Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia Open
PDF file - 80K, Polymorphisms in ATF5, ASNS and ASS1 genes analyzed in the relation to ASNase related complications.
View article: Data from Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia
Data from Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia Open
Purpose: Asparaginase (ASNase) is a standard and critical component in the therapy of childhood acute lymphoblastic leukemia (ALL), but it is also associated with several toxicities.Experimental design: We recently reported the results of …
View article: Data from <i>Bim</i> Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia
Data from <i>Bim</i> Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia Open
Purpose: Corticosteroids induce apoptosis in the malignant lymphoid cells and are critical component of combination therapy for acute lymphoblastic leukemia (ALL). Several genome-wide microarray studies showed major implication of proapopt…
View article: Data from Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia
Data from Polymorphisms of Asparaginase Pathway and Asparaginase-Related Complications in Children with Acute Lymphoblastic Leukemia Open
Purpose: Asparaginase (ASNase) is a standard and critical component in the therapy of childhood acute lymphoblastic leukemia (ALL), but it is also associated with several toxicities.Experimental design: We recently reported the results of …
View article: Supplementary Table 1 and 2 from <i>Bim</i> Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia
Supplementary Table 1 and 2 from <i>Bim</i> Polymorphisms: Influence on Function and Response to Treatment in Children with Acute Lymphoblastic Leukemia Open
Supplementary Table 1 and 2 - PDF file 68K, Supplementary Table 1. Identity of tagSNPs, details of PCR and ASO hybridization Supplementary Table 2. Identity of polymorphisms genotyped only in controls
View article: Pharmacogenetic Expression of CYP2C19 in a Pediatric Population
Pharmacogenetic Expression of CYP2C19 in a Pediatric Population Open
Genetic variability in CYP2C19 may be associated with both lack of efficacy and toxicity of drugs due to its different metabolic status based on the presence of particular alleles. This literature review summarizes current knowledge relati…
View article: HLA Alleles Associated with Asparaginase Hypersensitivity in Childhood ALL: A Report from the DFCI Consortium
HLA Alleles Associated with Asparaginase Hypersensitivity in Childhood ALL: A Report from the DFCI Consortium Open
Aim: To evaluate the association between human leukocyte antigen (HLA) alleles and native Escherichia coli asparaginase hypersensitivity (AH) in children with acute lymphoblastic leukemia (ALL) who received Dana-Farber Cancer Institute tre…
View article: Genes Identified Through Genome-wide Association Studies of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Patients
Genes Identified Through Genome-wide Association Studies of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Patients Open
Aim: To evaluate top-ranking genes identified through genome-wide association studies for an association with corticosteroid-related osteonecrosis in children with acute lymphoblastic leukemia (ALL) who received Dana-Farber Cancer Institut…
View article: Characterization of the microDNA through the response to chemotherapeutics in lymphoblastoid cell lines
Characterization of the microDNA through the response to chemotherapeutics in lymphoblastoid cell lines Open
Recently, a new class of extrachromosomal circular DNA, called microDNA, was identified. They are on average 100 to 400 bp long and are derived from unique non-repetitive genomic regions with high gene density. MicroDNAs are thought to ari…
View article: Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients
Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients Open
Allergy, pancreatitis and thrombosis are common side-effects of childhood acute lymphoblastic leukemia (ALL) treatment that are associated with the use of asparaginase (ASNase), a key component in most ALL treatment protocols. Starting wit…