Vincent Hayes
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View article: 6MO Translational relevance of the combined treatment PARP inhibitors and AsiDNA in homologous recombination proficient tumors
6MO Translational relevance of the combined treatment PARP inhibitors and AsiDNA in homologous recombination proficient tumors Open
View article: 6P AsiDNA targets drug-tolerant persister cells responsible of resistance to PARP inhibitors
6P AsiDNA targets drug-tolerant persister cells responsible of resistance to PARP inhibitors Open
View article: Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation
Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation Open
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by complexes between platelet factor 4 (PF4) and heparin or other polyanions, but the risk of thrombosis extends beyond exposure to heparin implicating other PF4 p…
View article: Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability
Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability Open
Cadherins play a major role in mediating cell–cell adhesion, which shares many parallels with platelet–platelet interactions during aggregate formation and clot stabilization. Platelets express epithelial (E)-cadherin, but its contribution…
View article: Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia
Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia Open
Key Points Development of thrombocytopenia in HIT is modulated by the (re)distribution of PF4 among hematopoietic and endothelial cell surfaces. Redistribution of PF4 from platelets to other hematopoietic cells may limit thrombocytopenia b…
View article: Enhancing functional platelet release in vivo from in vitro–grown megakaryocytes using small molecule inhibitors
Enhancing functional platelet release in vivo from in vitro–grown megakaryocytes using small molecule inhibitors Open
Key Points Drugs shown to enhance megakaryocyte ploidy and size variably effect terminal injury and apoptosis of in vitro–grown megakaryocytes. The number of functional platelets released in vivo from infused megakaryocytes can be enhanced…
View article: Threading an elephant through the eye of a needle: Where are platelets made?
Threading an elephant through the eye of a needle: Where are platelets made? Open
View article: Identifying and enriching platelet-producing human stem cell–derived megakaryocytes using factor V uptake
Identifying and enriching platelet-producing human stem cell–derived megakaryocytes using factor V uptake Open
Key Points Describe human MK populations representing distinct developmental stages within a heterogeneous culture. FV uptake identifies cultured MKs ready to release platelets upon infusion into mice.
View article: FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology
FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology Open
Key Points Paris-Trousseau syndrome is solely a result of FLI1 hemizygous deletion, with ETS1 levels being normal. Elevated FLI1 levels in megakaryocytes do not interfere with and may enhance megakaryopoiesis.
View article: Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia
Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia Open
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder initiated by antibodies against complexes between human platelet factor 4 (hPF4) and heparin. A better understanding of the events that initiate the prothrombotic state may…
View article: A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation
A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation Open
The use of fibrinolytic agents to prevent new thrombus formation is limited by an increased risk of bleeding due to lysis of hemostatic clots that prevent hemorrhage in damaged blood vessels. We sought to develop an agent that provides thr…
View article: Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia
Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia Open
Key Points The procoagulant nature of HIT can be simulated in a microfluidic model using human blood and its components. PF4/glycosaminoglycans/immunoglobulin G complexes activate monocytes through FcγRIIA to generate TF and thrombin, lead…
View article: Atomic description of the immune complex involved in heparin-induced thrombocytopenia
Atomic description of the immune complex involved in heparin-induced thrombocytopenia Open
Heparin-induced thrombocytopenia (HIT) is an autoimmune thrombotic disorder caused by immune complexes containing platelet factor 4 (PF4), antibodies to PF4 and heparin or cellular glycosaminoglycans (GAGs). Here we solve the crystal struc…
View article: Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells Open
Transfusion of donor-derived platelets is commonly used for thrombocytopenia, which results from a variety of clinical conditions and relies on a constant donor supply due to the limited shelf life of these cells. Embryonic stem (ES) and i…
View article: Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale
Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale Open
Key Points Infused human megakaryocytes release young platelets in the lungs with characteristics similar to donor platelets. Platelets released from ex vivo–derived megakaryocytes are preactivated and compare poorly to donor platelets.