Thomas V. Johnson
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View article: Clinical Outcomes of Hydrus Microstent Implantation for Open-Angle Glaucoma: Results from a Large Academic Center
Clinical Outcomes of Hydrus Microstent Implantation for Open-Angle Glaucoma: Results from a Large Academic Center Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells
Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells Open
Glaucoma is the leading cause of irreversible blindness, driven by the progressive loss of retinal ganglion cells (RGCs). Stem cell-derived RGC transplantation could revolutionize glaucoma treatment, but the inner limiting membrane (ILM) r…
View article: Compact lens-based dual-channel adaptive optics scanning laser ophthalmoscopy for <i>in-vivo</i> three-dimensional retinal imaging in mice
Compact lens-based dual-channel adaptive optics scanning laser ophthalmoscopy for <i>in-vivo</i> three-dimensional retinal imaging in mice Open
Adaptive optics (AO) has been instrumental in ophthalmic imaging, by correcting wavefront aberrations in ocular optics and achieving diffraction-limited resolution. Current state-of-the-art AO retinal imaging systems use mirror-based optic…
View article: Recommendations for the optimization of student led free vision screening programs
Recommendations for the optimization of student led free vision screening programs Open
Purpose To report the summary characteristics of operational models associated with Student Led Free Vision Screening Programs (SLFVSP) and to identify opportunities for program optimization. Methods An 81-question mixed methods survey was…
View article: The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy
The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy Open
Topical Rip reduced RGC loss in GL and ON crush, with suppression of ROCK signaling in the retina and ON. The neuroprotection mechanisms appear to involve effects on both RGC and astrocyte responses to IOP elevation.
View article: The relationship between intraocular pressure and glaucoma: An evolving concept
The relationship between intraocular pressure and glaucoma: An evolving concept Open
Intraocular pressure (IOP) is the most important modifiable risk factor for glaucoma and fluctuates considerably within patients over short and long time periods. Our field's understanding of IOP has evolved considerably in recent years, d…
View article: Macular Degeneration Drug Prescribing Patterns After Step Therapy Introduction in Medicare Advantage
Macular Degeneration Drug Prescribing Patterns After Step Therapy Introduction in Medicare Advantage Open
Importance In Medicare Advantage (MA), step therapy for physician-administered drugs is an approach to lowering drug spending. The impact of step therapy in MA on prescribing behavior and the magnitude of any changes has not been analyzed.…
View article: Capabilities and Limitations of Student-Led Free Vision Screening Programs in the United States
Capabilities and Limitations of Student-Led Free Vision Screening Programs in the United States Open
The CSLEC aims to develop a consensus-based standardization for the scope of screening services, offer guidelines for diagnostic criteria, promote real-time data stewardship, and identify means to improve follow-up care mechanisms in membe…
View article: Comparison of the Biomechanics of the Mouse Astrocytic Lamina Cribrosa Between Glaucoma and Optic Nerve Crush Models
Comparison of the Biomechanics of the Mouse Astrocytic Lamina Cribrosa Between Glaucoma and Optic Nerve Crush Models Open
We found alterations in the ex vivo mechanical behavior in eyes from mice with experimental glaucoma but not in those with crushed optic nerves. The results of this study demonstrate that significant axon injury does not directly affect me…
View article: Prediction of MIGS outcomes on second eyes using first eyes’ response
Prediction of MIGS outcomes on second eyes using first eyes’ response Open
To evaluate how well outcomes following cataract extraction and microinvasive glaucoma surgery in one eye predict outcomes in sequential second eye. Retrospective study of 78 patients who underwent cataract extraction and microinvasive gla…
View article: Regional Gene Expression in the Retina, Optic Nerve Head, and Optic Nerve of Mice with Optic Nerve Crush and Experimental Glaucoma
Regional Gene Expression in the Retina, Optic Nerve Head, and Optic Nerve of Mice with Optic Nerve Crush and Experimental Glaucoma Open
A major risk factor for glaucomatous optic neuropathy is the level of intraocular pressure (IOP), which can lead to retinal ganglion cell axon injury and cell death. The optic nerve has a rostral unmyelinated portion at the optic nerve hea…
View article: The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium
The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Comparing Ahmed-FP7 to Baerveldt-250 and Baerveldt-350 surgical outcomes: 1-year results from a retrospective cohort study leveraging the electronic health record
Comparing Ahmed-FP7 to Baerveldt-250 and Baerveldt-350 surgical outcomes: 1-year results from a retrospective cohort study leveraging the electronic health record Open
Objective To compare outcomes following Ahmed-FP7 (AGI-FP7), Baerveldt-250mm 2 (BGI-250), or Baerveldt-350mm 2 (BGI-350) implantation. Methods and analysis Retrospective cohort study comprising 800 eyes from 800 individuals who underwent s…
View article: A Coming of Age for Glaucoma Neuroprotection
A Coming of Age for Glaucoma Neuroprotection Open
Glaucoma neuroprotection encompasses treatments capable of reducing retinal ganglion cell injury or death through a mechanism independent of, and potentially complementary to, intraocular pressure (IOP) reduction. The need for neuroprotect…
View article: Preparedness and response of assisted living facilities toward COVID-19 infection control in Houston, Texas, USA
Preparedness and response of assisted living facilities toward COVID-19 infection control in Houston, Texas, USA Open
Background Long-term care facilities (LTCFs) including assisted living facilities (ALFs) are hubs for high transmission and poor prognosis of COVID-19 among the residents who are more susceptible due to old age and comorbidities. Aim Houst…
View article: Regional Gene Expression in the Retina, Optic Nerve Head, and Optic Nerve of Mice with Experimental Glaucoma and Optic Nerve Crush
Regional Gene Expression in the Retina, Optic Nerve Head, and Optic Nerve of Mice with Experimental Glaucoma and Optic Nerve Crush Open
A major risk factor for glaucomatous optic neuropathy is the level of intraocular pressure (IOP), which can lead to retinal ganglion cell axon injury and cell death. The optic nerve has a rostral unmyelinated portion at the optic nerve hea…
View article: HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease Open
Tight glycemic control (TGC), the cornerstone of diabetic management, reduces the incidence and progression of diabetic microvascular disease. However, TGC can also lead to transient episodes of hypoglycemia, which have been associated wit…
View article: Internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells
Internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells Open
Optic neuropathies cause irreversible vision loss as retinal ganglion cells (RGCs) die. Transplantation of pluripotent stem cell (PSC)-derived RGCs offers one potential therapeutic avenue to restore vision in patients suffering from optic …
View article: Formulation and Evaluation of Polymer‐Based Nanoparticles for Intravitreal Gene‐Delivery Applications
Formulation and Evaluation of Polymer‐Based Nanoparticles for Intravitreal Gene‐Delivery Applications Open
The advent of the first‐ever retinal gene therapy product, involving subretinal administration of a virus‐based gene delivery platform, has garnered hope that this state‐of‐the‐art therapeutic modality may benefit a broad spectrum of patie…
View article: Quantitative Microstructural Analysis of Cellular and Tissue Remodeling in Human Glaucoma Optic Nerve Head
Quantitative Microstructural Analysis of Cellular and Tissue Remodeling in Human Glaucoma Optic Nerve Head Open
Alteration in LC structure in glaucoma involves migration of astrocytes into axonal bundles, change in astrocyte orientation and processes, production of basement membrane material, and thinning of connective tissue beams.
View article: Association Between Open Payments–Reported Industry Transfers of Value and Prostaglandin Analog Prescribing in the US
Association Between Open Payments–Reported Industry Transfers of Value and Prostaglandin Analog Prescribing in the US Open
Importance Reported transfers of value (TOV) from pharmaceutical companies have been associated with greater use of branded anti–vascular endothelial growth factor agents by ophthalmologists, but payment under the Medicare Part B buy-and-b…
View article: Restoring partial vision to a blind patient
Restoring partial vision to a blind patient Open
This paper reports an important breakthrough in partially restoring sight to a man who had lost his vision due to retinitis pigmentosa (RP), a heritable retinal degenerative disease that affects approximately 1 in 4000 people. Long conside…
View article: Aquaporin 4 is not present in normal porcine and human lamina cribrosa
Aquaporin 4 is not present in normal porcine and human lamina cribrosa Open
Aquaporin 4 is absent from astrocytes in the rodent optic nerve head, despite high expression in the retina and myelinated optic nerve. The purpose of this study was to quantify regional aquaporin channel expression in astrocytes of the po…
View article: Analyses of transplanted human retinal ganglion cell morphology and localization in murine organotypic retinal explant culture
Analyses of transplanted human retinal ganglion cell morphology and localization in murine organotypic retinal explant culture Open
Retinal ganglion cell (RGC) transplantation has the potential to restore vision in optic neuropathy, but donor neuron survival and retinal integration remain challenging. Here, we present a protocol for ex vivo human RGC transplantation on…