Vincent Lo Re
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Changes in Three-Dimensional Volumetric Liver Fat Fraction after Cure of Chronic Hepatitis C Infection with Direct-Acting Antivirals Open
Background It remains unclear if cure of hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) leads to change in liver fat fraction and if this change differs from people without HCV observed over similar time. We evaluat…
Development and Validation of Case‐Finding Algorithms to Identify Periprosthetic Joint Infections After Total Hip Arthroplasty in Veterans Health Administration Data Open
Purpose To determine the positive predictive values (PPVs) of ICD‐9‐ and ICD‐10‐based diagnostic coding algorithms to identify periprosthetic joint infection (PJI) following total hip arthroplasty (THA) within the United States (US) Vetera…
High‐Throughput Screening Using the Self‐Controlled Tree‐Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury Open
Background Medications associated with acute liver injury (ALI) are primarily identified by case reports. High‐throughput screening of real‐world data could be leveraged to detect hepatotoxicity signals. Objective To apply tree‐based scan …
Changes in Bone Microarchitecture and Inflammatory Cytokines after Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy Open
Background It remains unclear if cure of hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) ameliorates HCV-related inflammation and bone deficits. We evaluated changes in cytokines and bone measurements by high resolut…
Magnetic resonance evaluation of three-dimensional liver fat fraction by hepatitis C status and associations with inflammatory cytokines Open
Background Chronic hepatitis C virus (HCV) infection may influence cytokine and insulin-like growth factor (IGF-1) levels, which could contribute to increased hepatic steatosis. We utilized MRI to compare three-dimensional volumetric liver…
View article: Adaptation of Risk Score for Hepatocellular Carcinoma Without Alcohol Measures
Adaptation of Risk Score for Hepatocellular Carcinoma Without Alcohol Measures Open
This diagnostic study validates hepatocellular carcinoma risk scores without alcohol measures in veterans with and without alcohol use disorder.
View article: Effectiveness of an Embedded Infectious Disease Screening, Treatment, and Prevention Intervention Within an Inpatient Substance Use Treatment Program
Effectiveness of an Embedded Infectious Disease Screening, Treatment, and Prevention Intervention Within an Inpatient Substance Use Treatment Program Open
Background People with substance use disorders (SUDs) are at higher risk for infectious diseases (IDs). Co-locating ID screening services within inpatient SUD treatment programs may decrease barriers to care; however, the impact of such sc…
View article: Data from Differences in Pathology, Staging, and Treatment between HIV<sup>+</sup> and Uninfected Patients with Microscopically Confirmed Hepatocellular Carcinoma
Data from Differences in Pathology, Staging, and Treatment between HIV<sup>+</sup> and Uninfected Patients with Microscopically Confirmed Hepatocellular Carcinoma Open
Background:The incidence of hepatocellular carcinoma (HCC) is substantially higher among HIV-infected (HIV+) than uninfected persons. It remains unclear if HCC in the setting of HIV infection is morphologically distinct or more aggressive.…
View article: Supplementary Tables 1-9 from Differences in Pathology, Staging, and Treatment between HIV<sup>+</sup> and Uninfected Patients with Microscopically Confirmed Hepatocellular Carcinoma
Supplementary Tables 1-9 from Differences in Pathology, Staging, and Treatment between HIV<sup>+</sup> and Uninfected Patients with Microscopically Confirmed Hepatocellular Carcinoma Open
Supplemental Table 1. Current Procedural Terminology (CPT) codes identifying treatments for hepatocellular carcinoma. Supplemental Table 2. Clinical characteristics of patients with confirmed hepatocellular carcinoma diagnosis in the Veter…
View article: Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes
Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes Open
Background The absence of validated methods to identify cholangiocarcinoma in real‐world data has prevented the conduct of pharmacoepidemiologic studies to evaluate determinants of this malignancy and examine the effectiveness of cholangio…
Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines Open
Background Hepatitis C virus (HCV) infection is associated with reduced bone mineral density (BMD) and increased fracture risk. The structural underpinnings for skeletal fragility with HCV and contributions of inflammatory cytokines remain…
View article: Glucagon-like peptide-1 receptor agonists, but not dipeptidyl peptidase-4 inhibitors, reduce alcohol intake
Glucagon-like peptide-1 receptor agonists, but not dipeptidyl peptidase-4 inhibitors, reduce alcohol intake Open
BACKGROUNDDespite growing preclinical evidence that glucagon-like peptide1 receptor agonists (GLP-1RAs) could be repurposed to treat alcohol use disorder (AUD), clinical evidence is scarce. Additionally, the potential impact of dipeptidyl …
View article: Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status
Hepatotoxicity Score: A New Method to Adjust for Use of Potentially Hepatotoxic Medications by Chronic Liver Disease Status Open
Background Studies evaluating the hepatic safety of medications have been limited by the inability to control for confounding from receipt of other hepatotoxic drugs. Objective The objective of this study was to develop an index (Hepatotox…
View article: Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis
Risk Score for Hepatocellular Cancer in Adults Without Viral Hepatitis or Cirrhosis Open
Importance Hepatocellular carcinoma (HCC) is typically detected only at advanced stages when treatment options are limited. Most of the current HCC risk models focus on patients with viral hepatitis or diagnosed cirrhosis or require variab…
A Validated Algorithm to Identify Hepatic Decompensation in the Veterans Health Administration Electronic Health Record System Open
Purpose Accurate identification of hepatic decompensation is essential for pharmacoepidemiologic research among patients with chronic liver disease. Methods An algorithm using ≥ 1 inpatient or ≥ 2 outpatient International Classification of…
View article: Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data
Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data Open
Importance Current approaches to classify the hepatotoxic potential of medications are based on cumulative case reports of acute liver injury (ALI), which do not consider the size of the exposed population. There is little evidence from re…
View article: Identification of hepatic steatosis among persons with and without HIV using natural language processing
Identification of hepatic steatosis among persons with and without HIV using natural language processing Open
Background: Steatotic liver disease (SLD) is a growing phenomenon, and our understanding of its determinants has been limited by our ability to identify it clinically. Natural language processing (NLP) can potentially identify hepatic stea…
View article: Risk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States
Risk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States Open
There was heterogeneity by country in 90-day absolute risk of ATE and VTE after ambulatory COVID-19 diagnosis both before and during COVID-19 vaccine availability.
View article: 1312. Incidence and Microbiology of Prosthetic Joint Infection According to Time Following Total Knee Arthroplasty: A Retrospective Cohort Study Among US Veterans
1312. Incidence and Microbiology of Prosthetic Joint Infection According to Time Following Total Knee Arthroplasty: A Retrospective Cohort Study Among US Veterans Open
Background Despite the frequency of total knee arthroplasty (TKA) and clinical impact of prosthetic joint infections (PJIs), the incidence and microbiology of these infections in the United States remains unclear. Our objective was to dete…
View article: 1313. Determinants of Prosthetic Joint Infection According to Time Following Total Knee Arthroplasty: A Retrospective Cohort Study Among US Veterans
1313. Determinants of Prosthetic Joint Infection According to Time Following Total Knee Arthroplasty: A Retrospective Cohort Study Among US Veterans Open
Background Despite the clinical impact of prosthetic joint infections (PJIs), the factors associated with these infections remain unclear. We sought to determine patient and surgical determinants of PJIs occurring ≤ 3 months (early period)…
View article: Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty
Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty Open
Importance Despite the frequency of total knee arthroplasty (TKA) and clinical implications of prosthetic joint infections (PJIs), knowledge gaps remain concerning the incidence, microbiological study results, and factors associated with t…
Oral Health Outcomes In An HIV Cohort With Comorbidities- Implementation Roadmap For A Longitudinal Prospective Observational Study Open
Long-term antiretroviral therapy (ART) perpetually suppresses HIV load and has dramatically altered the prognosis of HIV infection, such that HIV is now regarded as a chronic disease. Side effects of ART in Patients With HIV (PWH), has int…
View article: Alcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy
Alcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy Open
Importance Some payers and clinicians require alcohol abstinence to receive direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection. Objective To evaluate whether alcohol use at DAA treatment initiation is assoc…
View article: Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012–2016
Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012–2016 Open
A care cascade is a critical tool for evaluating delivery of care for chronic infections across sequential stages, starting with diagnosis and ending with viral suppression. However, there have been few data describing the hepatitis B viru…
Prevalence and determinants of hepatitis delta virus infection among <span>HIV</span>/hepatitis <span>B‐coinfected</span> adults in care in the United States Open
Hepatitis delta virus (HDV) infection increases the risk of liver complications compared to hepatitis B virus (HBV) alone, particularly among persons with human immunodeficiency virus (HIV). However, no studies have evaluated the prevalenc…
Association between treatment of hepatitis C virus and risk of cardiovascular disease among insured patients with the virus in the United States Open
Purpose Hepatitis C virus (HCV) infection has been associated with increased risk of cardiovascular disease (CVD). It is unclear whether HCV treatment affects risk of CVD among patients infected with HCV. We assessed the incidence and risk…
Performance of an automated deep learning algorithm to identify hepatic steatosis within noncontrast computed tomography scans among people with and without <span>HIV</span> Open
Purpose Hepatic steatosis (fatty liver disease) affects 25% of the world's population, particularly people with HIV (PWH). Pharmacoepidemiologic studies to identify medications associated with steatosis have not been conducted because meth…