Vincent Rouilly
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View article: Intratumoral cDC1-T Cell Clusters Serve as Sites of Local Costimulation to Enhance CTL-Mediated Tumor Rejection
Intratumoral cDC1-T Cell Clusters Serve as Sites of Local Costimulation to Enhance CTL-Mediated Tumor Rejection Open
Summary T cells are essential for anti-tumor immunity, but their ability to eliminate tumors depends on coordinated interactions with type 1 conventional dendritic cells (cDC1s). While cDC1s are known for cross-presenting tumor-derived ant…
View article: The Milieu Interieur follow-up study - an integrative approach for studying immunological variation in an aging population
The Milieu Interieur follow-up study - an integrative approach for studying immunological variation in an aging population Open
Human immune responses are highly variable from one individual to another, with these differences determined by both genetic and environmental factors. We previously established the Milieu Interieur cohort to define the boundaries of healt…
View article: Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses Open
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis ( M. tb ) infection impacts host immune responses. We compared the induced immune response to TB antigen, B…
View article: Defective type I interferon immunity is associated with increasing COVID-19 severity
Defective type I interferon immunity is associated with increasing COVID-19 severity Open
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death. We previously reported that reduced blood type I interferon (IFN-I) in severe COVID-1…
View article: SCHNAPPs - Single Cell sHiNy APPlication(s)
SCHNAPPs - Single Cell sHiNy APPlication(s) Open
Single-cell RNA-sequencing (scRNAseq) experiments are becoming a standard tool for bench-scientists to explore the cellular diversity present in all tissues. Data produced by scRNAseq is technically complex and requires analytical workflow…
View article: Distinct systemic and mucosal immune responses to SARS-CoV-2
Distinct systemic and mucosal immune responses to SARS-CoV-2 Open
Summary Coordinated local mucosal and systemic immune responses following SARS-CoV-2 infection protect against COVID-19 pathologies or fail leading to severe clinical outcomes. To understand this process, we performed an integrated analysi…
View article: Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation in health and disease
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation in health and disease Open
Summary The IL-12 family of cytokines comprises the only heterodimeric cytokines mediating diverse functional effects. We previously observed a bi-modal IL-12p70 response to LPS in healthy donors of the Milieu Interieur cohort. Herein, we …
View article: Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses Open
SUMMARY Tuberculosis (TB) remains a major public health problem with host-directed therapeutics offering potential as novel treatment strategies. However, their successful development still requires a comprehensive understanding of how Myc…
View article: Immune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or <i>Mycobacteriu</i> <i>m tuberculosis</i> Infection
Immune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or <i>Mycobacteriu</i> <i>m tuberculosis</i> Infection Open
Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) infection and is a major public health problem. Clinical challenges include the lack of a blood-based test for active disease. Current blood-based tests, such as Qu…
View article: SCHNAPPs - Single Cell sHiNy APPlication(s)
SCHNAPPs - Single Cell sHiNy APPlication(s) Open
Motivation Single-cell RNA-sequencing (scRNAseq) experiments are becoming a standard tool for bench-scientists to explore the cellular diversity present in all tissues. On one hand, the data produced by scRNASeq is technically complex, wit…
View article: Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer
Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer Open
PD-1 and PD-L1 act to restrict T cell responses in cancer and contribute to self-tolerance. Consistent with this role, PD-1 checkpoint inhibitors have been associated with immune-related adverse events (irAEs), immune toxicities thought to…
View article: Polygenic Risk for Skin Autoimmunity Impacts Immune Checkpoint Blockade in Bladder Cancer
Polygenic Risk for Skin Autoimmunity Impacts Immune Checkpoint Blockade in Bladder Cancer Open
PD-1 and PD-L1 act to restrict T-cell responses in cancer and contribute to self-tolerance. Consistent with this role, PD-1 checkpoint inhibitors have been associated with immune-related adverse events (irAEs), immune toxicities thought to…
View article: Immune profiling in M. tuberculosis infection enables stratification of patients with active disease
Immune profiling in M. tuberculosis infection enables stratification of patients with active disease Open
Tuberculosis (TB) is caused by Mycobacterium tuberculosis ( Mtb ) infection and is a major public health problem with an estimated 1.7 billion persons infected worldwide. Clinical challenges in TB include the lack of a blood-based test for…
View article: T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation
T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation Open
Conflict of interest: T.J. Scriba reports grants received from BMGF by University of Cape Town, during the conduct of the study.Conflict of interest: E. Nemes received grants from the Bill and Melinda Gates Foundation, during the conduct o…
View article: Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges Open
Significance Identifying the drivers of the interindividual diversity of the human immune system is crucial to understand their consequences on immune-mediated diseases. By examining the transcriptional responses of 1,000 individuals to va…