Vincent See
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View article: Ablation of idiopathic ventricular arrhythmias from the right ventricular apex
Ablation of idiopathic ventricular arrhythmias from the right ventricular apex Open
RV apical VAs demonstrate a distinctive ECG morphology that aids localization. Catheter ablation is effective but may require an epicardial approach.
View article: Sucroferric oxyhydroxide use in patients on haemodialysis – real-world experience from an Asian cohort
Sucroferric oxyhydroxide use in patients on haemodialysis – real-world experience from an Asian cohort Open
Background Sucroferric oxyhydroxide has been used in the treatment of hyperphosphataemia in adult patients with chronic kidney disease receiving haemodialysis or peritoneal dialysis since 2013. However, there is a paucity of data on sucrof…
View article: Metabolic Scar Assessment with<sup>18</sup>F-FDG PET: Correlation to Ischemic Ventricular Tachycardia Substrate and Successful Ablation Sites
Metabolic Scar Assessment with<sup>18</sup>F-FDG PET: Correlation to Ischemic Ventricular Tachycardia Substrate and Successful Ablation Sites Open
The functional and molecular imaging characteristics of ischemic ventricular tachycardia (VT) substrate are incompletely understood. Our objective was to compare regional 18F-FDG PET tracer uptake with detailed electroanatomic maps (EAMs) …
View article: A case of withheld defibrillator treatment for 9 minutes of ventricular tachycardia
A case of withheld defibrillator treatment for 9 minutes of ventricular tachycardia Open
Implantable cardioverter-defibrillators (ICDs) reduce mortality in high-risk populations by sensing and appropriately treating ventricular tachyarrhythmias with either antitachycardia pacing or high-voltage shock.1 An adverse effect of ICD…
View article: <i>KCNQ1</i> and Long QT Syndrome in 1/45 Amish
<i>KCNQ1</i> and Long QT Syndrome in 1/45 Amish Open
Background: In population-based research exome sequencing, the path from variant discovery to return of results is not well established. Variants discovered by research exome sequencing have the potential to improve population health. Meth…
View article: Wearing Your Heart on Your Wrist
Wearing Your Heart on Your Wrist Open
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View article: Clinical Pharmacology‐Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy
Clinical Pharmacology‐Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy Open
Oral sotalol, used in adults for sinus rhythm control, is initiated at 80 mg b.i.d. and titrated to a maximum safe dose. The US Food and Drug Administration recommends monitoring the corrected QT interval (QT c ) for at least 3 days, until…
View article: Challenges and opportunities for integrating genetic testing into a diagnostic workflow: heritable long QT syndrome as a model
Challenges and opportunities for integrating genetic testing into a diagnostic workflow: heritable long QT syndrome as a model Open
Background An increasing number of diagnostic evaluations incorporate genetic testing to facilitate accurate and timely diagnoses. The increasing number and complexity of genetic tests continue to pose challenges in deciding when to test, …
View article: Ventricular Tachycardia (VT) Substrate Characteristics: Insights from Multimodality Structural and Functional Imaging of the VT Substrate Using Cardiac MRI Scar, <sup>123</sup>I-Metaiodobenzylguanidine SPECT Innervation, and Bipolar Voltage
Ventricular Tachycardia (VT) Substrate Characteristics: Insights from Multimodality Structural and Functional Imaging of the VT Substrate Using Cardiac MRI Scar, <sup>123</sup>I-Metaiodobenzylguanidine SPECT Innervation, and Bipolar Voltage Open
Postischemic adaptation results in characteristic myocardial structural and functional changes in the ventricular tachycardia (VT) substrate. The aim of this study was to compare myocardial structural and functional adaptations (late gadol…
View article: A review of the LARIAT device: insights from the cumulative clinical experience
A review of the LARIAT device: insights from the cumulative clinical experience Open
Atrial fibrillation (AF) is the most common arrhythmic disorder world-wide, accounting for 15 % of all strokes. Management of stroke risk in AF is complicated by intolerance of anti-coagulation (AC) therapy and difficulty maintaining thera…
View article: Global and Regional Myocardial Innervation Before and After Ablation of Drug-Refractory Ventricular Tachycardia Assessed with <sup>123</sup>I-MIBG
Global and Regional Myocardial Innervation Before and After Ablation of Drug-Refractory Ventricular Tachycardia Assessed with <sup>123</sup>I-MIBG Open
Patients with ischemic cardiomyopathy have larger areas of abnormal innervation than those with nonischemic cardiomyopathy. Although VT ablation did not change global innervation, a novel arrhythmia-specific segmental analysis demonstrated…
View article: Three-Dimensional <sup>123</sup> I- <i>Meta</i> -Iodobenzylguanidine Cardiac Innervation Maps to Assess Substrate and Successful Ablation Sites for Ventricular Tachycardia
Three-Dimensional <sup>123</sup> I- <i>Meta</i> -Iodobenzylguanidine Cardiac Innervation Maps to Assess Substrate and Successful Ablation Sites for Ventricular Tachycardia Open
Background— Innervation is a critical component of arrhythmogenesis and may present an important trigger/substrate modifier not used in current ventricular tachycardia (VT) ablation strategies. Methods and Results— Fifteen patients referre…