Explanipedia

Triarylphosphonium BODIPY‐Based [2]Rotaxanes Nanoparticles for Light‐Driven Antibacterial Applications Open

Greta Sambucari, Corinne Coutant, Alessandro Di Michele, Gina Elena Giacomazzo, Pierrick Nun , et al. · 2025

Antimicrobial photodynamic therapy (aPDT) is a promising strategy to overcome issues related to antibiotic resistance. Here the rationale for designing new photosensitizers is described based on the functionalization of bodipy dyes with tr…

Synthesis of long-wavelength-absorbing photosensitizer/nanoparticle conjugates and their in vitro PDT evaluation on colorectal cancer cell lines Open

Luce Janice Ndzimbou, Rayan Chkair, Gautier M.A. Ndong Ntoutoume, Mona Diab‐Assaf, Guillaume Chemin , et al. · 2025

Starting from purpurin-18, a stable purpurin-18 imide derivative with intensive absorption in the near infrared has been synthesized. The opening of the exocycle anhydride by a primary alkylamine bearing an adamantyl group, allows after cy…

Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy Open

Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre, Vincent Sol, Youness Limami , et al. · 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite its promising therapeutic potential, its poor bioavailability, rapid metabolism, …

Activity of Hydrophilic, Biocompatible, Fluorescent, Organic Nanoparticles Functionalized with Purpurin-18 in Photodynamic Therapy for Colorectal Cancer Open

Rayan Chkair, Justine Couvez, Frédérique Brégier, Mona Diab‐Assaf, Vincent Sol , et al. · 2024

Photodynamic therapy (PDT) is a clinically approved, non-invasive therapy currently used for several solid tumors, triggering cell death through the generation of reactive oxygen species (ROS). However, the hydrophobic nature of most of th…

Synthesis and Antiproliferative Effect of 3,4,5-Trimethoxylated Chalcones on Colorectal and Prostatic Cancer Cells Open

Cécile Letulle, François‐Xavier Toublet, Aline Pinon, Soufyane Hba, Aurélie Laurent , et al. · 2024

In the context of designing innovative anticancer agents, the synthesis of a series of chalcones bearing a 3,4,5-trimethoxylated A ring and a variety of B rings, including phenols and original heterocycles such as chromones, was conducted.…

Phototoxicity of the Ethanolic Extract of Skeletonema marinoi for the Dermocosmetic Improvement of Acne Open

J Bérard, Tan‐Sothéa Ouk, Vincent Sol, Louise Lefoulon, Cornelia Landolt , et al. · 2024

Acne is one of the most common dermatological conditions, peaking during adolescence and early adulthood, affecting about 85% of individuals aged 12–24. Although often associated with teenage years, acne can occur at any age, impacting ove…

Disentangling the effects of carbon monoxide and singlet oxygen in photoCORM-based nanomaterials for antimicrobial therapeutics Open

Valentine Guilbaud, Corinne Vanucci‐Bacqué, Florence Bedos‐Belval, Tan-Sothea Ouk, Gautier M.-A. Ndong-Ntoutoume , et al. · 2024

International audience

Development of photoactivatable CO-releasing tricarbonylrhenium(I) complexes and their integration into cellulose nanocrystals in view of antibacterial activity Open

Valentine Guilbaud, Marie Goizet, Nadine Leygue, Alexandre Poirot, Sonia Mallet−Ladeira , et al. · 2024

Hydrophilic Biocompatible Fluorescent Organic Nanoparticles as Nanocarriers for Biosourced Photosensitizers for Photodynamic Therapy Open

Isabelle Sasaki, Frédérique Brégier, Guillaume Chemin, Jonathan Daniel, Justine Couvez , et al. · 2024

Most photosensitizers of interest for photodynamic therapy—especially porphyrinoids and chlorins—are hydrophobic. To circumvent this difficulty, the use of nanocarriers is an attractive strategy. In this perspective, we have developed high…

Improvement of Charcot-Marie-Tooth Phenotype with a Nanocomplex Treatment in Two Transgenic Models of CMT1A Open

Mohamed El Massry, Zeina Msheik, Tarek El Masri, Gautier MA Ndong Ntoutoume, Laetitia Vignaud , et al. · 2024

Curcumin has been shown to exert beneficial effects in peripheral neuropathies. Despite its known biological activities, curcumin has unfavorable pharmacokinetics. Its instability has been linked to its failure in clinical trials of curcum…

Development of Photoactivatable Co-Releasing Tricarbonylrhenium(I) Complexes and Their Integration into Cellulose Nanocrystals in View of Antibacterial Activity Open

Valentine Guilbaud, Marie Goizet, Nadine Leygue, Alexandre Poirot, Sonia Mallet−Ladeira , et al. · 2024

Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles Open

Soufyane Hba, Suzan Ghaddar, Hicham Wahnou, Aline Pinon, Riad El Kebbaj , et al. · 2023

Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates …

A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers Open

R. Petit, Jonathan Izambart, Mathieu Guillou, Jackson Roberto Guedes da Silva Almeida, Raimundo Gonçalves de Oliveira Júnior , et al. · 2023

This study provides a comprehensive overview of the current knowledge regarding phototoxic terrestrial plants and their phototoxic and photosensitizing metabolites. Within the 435,000 land plant species, only around 250 vascular plants hav…

The Promise of Piperine in Cancer Chemoprevention Open

S. Benayad, Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre, Vincent Sol , et al. · 2023

Cancer, characterized by the unregulated growth and dissemination of malignantly transformed cells, presents a significant global health challenge. The multistage process of cancer development involves intricate biochemical and genetic alt…

Polyphenol Content, Antioxidant, and Antibiotic Activities of <i>Pinus Caribaea</i> Morelet Forestry Coproducts Open

Cynthia Sinyeue, Louisa Maerker, Linda Guentas, Valérie Medevielle, Frédérique Brégier , et al. · 2023

Context and objective In the context of valorization of wood waste from the timber industry, this work aims to study the chemical composition and to evaluate the biological capacities of coproducts from Pinus caribaea Morelet. Methods With…

Thermodynamic and structural properties of lipid-photosensitizer conjugates mixed with phospholipids: Impact on the formation and stability of nano-assemblies Open

David Chapron, Jean‐Philippe Michel, Philippe Fontaine, Jérémy Godard, Frédérique Brégier , et al. · 2023

Effects of Lagarosiphon major extracts on the metabolome and photosynthesis of Microcystis aeruginosa Open

Juliette Tison‐Rosebery, Sylvia Moreira, Mélissa Éon, Lucie Campillo, Samuel Maubert , et al. · 2023

Over the last decades, Aquitaine lakes have been exposed to growing biomasses of invasive macrophytes, in particular Lagarosiphon major , and to frequent blooms of the cyanobacteria Microcystis aeruginosa . Our aim was to explore the poten…

Enforcing local DNA kinks by sequence-selective trisintercalating oligopeptides of a tricationic porphyrin. A polarizable Molecular Dynamics study Open

Nohad Gresh, Krystel El Hage, Louis Lagardère, Frédérique Brégier, Jérémy Godard , et al. · 2023

Summary Bisacridinyl-bisarginyl porphyrin (BABAP) is a trisintercalating derivative of a tricationic porphyrin, formerly designed and synthesized in order to selectively target and photosensitize the ten-base pair palindromic sequence d(CG…

Polyphenol-Based Nanoparticles: A Promising Frontier for Enhanced Colorectal Cancer Treatment Open

Hicham Wahnou, Bertrand Liagre, Vincent Sol, H. El Attar, Rükset Attar , et al. · 2023

Colorectal cancer (CRC) poses a significant challenge in healthcare, necessitating the exploration of novel therapeutic strategies. Natural compounds such as polyphenols with inherent anticancer properties have gained attention as potentia…

Spatial Division Multiplexing for Multiplex Coherent Anti-Stokes Raman Scattering Open

Tigran Mansuryan, Alessandro Tonello, Katarzyna Krupa, Alexis Desmoulière, G. Ndong Ntoutoume , et al. · 2023

We demonstrate how a narrowband pump and a broadband spectrum can be spatially multiplexed by selective coupling them in two distinct modes of a few-mode microstructure fiber. The first mode carries most of the input pump energy, and exper…

Shining a Light on Prostate Cancer: Photodynamic Therapy and Combination Approaches Open

Hicham Wahnou, Ibtissam Youlyouz‐Marfak, Bertrand Liagre, Vincent Sol, Mounia Oudghiri , et al. · 2023

Prostate cancer is a major health concern worldwide, and current treatments, such as surgery, radiation therapy, and chemotherapy, are associated with significant side effects and limitations. Photodynamic therapy (PDT) is a promising alte…

Improvement of Charcot-Marie-Tooth Phenotype with a Nanocomplex Treatment in Two Transgenic Models of CMT1A Open

Zeina Msheik, Tarek El Masri, Gautier M.A. Ndong-Ntoutoume, Laetitia Vignaud, Laurence Richard , et al. · 2023

Curcumin was shown to exert beneficial effects on nerve function in peripheral neuropathies. Despite its prominent biological activities, curcumin presents with unfavorable pharmacokinetics. For this purpose, we have developed curcumin-loa…

Porphyrin metalla-assemblies coupled to cellulose nanocrystals for PDT and imaging applications Open

João C. S. Simões, Georges Wagnières, Sophia Sarpaki, Vincent Sol, Bruno Therrien · 2023

Photodynamic therapy (PDT) is an interesting and promising approach to tackle a broad spectrum of cancer. With the combination of a photosensitizer, light and oxygen, PDT achieves a unique selectivity by the production of localized reactiv…

Xylan–Porphyrin Hydrogels as Light-Triggered Gram-Positive Antibacterial Agents Open

Abdechakour Elkihel, Charlotte Vernisse, Tan‐Sothéa Ouk, Romain Lucas, Vincent Chaleix , et al. · 2023

In the present work, we report on the synthesis of light-triggered antibacterial hydrogels, based on xylan chains covalently bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). Not only does TCPP act as a photosensitizer efficient agains…

Porphyrin Metalla-Assemblies Coupled to Cellulose Nanocrystals for PDT and Imaging Applications Open

João C. S. Simões, Georges Wagnières, Sophia Sarpaki, Vincent Sol, Bruno Therrien · 2022

Photodynamic therapy (PDT) is an interesting and promising approach to tackle a broad spectrum of cancer types. With the combination of a photosensitizer, light and oxygen, PDT achieves a unique selectivity by the production of localized r…

First Example of a Heptazine-Porphyrin Dyad; Synthesis and Spectroscopic Properties Open

Frédérique Brégier, Vincent Sol, Yves Champavier, Laurent Galmiche, Clémence Allain , et al. · 2022

We have prepared the first example of a porphyrin linked to an heptazine photoactive antenna. The two entities, linked with an alkyl spacer, demonstrate the activity of both active moieties. While they behave electrochemically independantl…

Coherent anti-Stokes Raman scattering cell imaging and segmentation with unsupervised data analysis Open

Damien Boildieu, Tiffany Guerenne-Del Ben, Ludovic Duponchel, Vincent Sol, Jean‐Michel Petit , et al. · 2022

Coherent Raman imaging has been extensively applied to live-cell imaging in the last 2 decades, allowing to probe the intracellular lipid, protein, nucleic acid, and water content with a high-acquisition rate and sensitivity. In this conte…

Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a π-Extended Porphyrin Open

Charly Gourlot, Alexis Gosset, Elise Glattard, Christopher Aisenbrey, Sabarinathan Rangasamy , et al. · 2022

The increase of antimicrobial resistance to conventional antibiotics is worldwide a major health problem that requires the development of new bactericidal strategies. Antimicrobial photodynamic therapy (a-PDT) that generates reactive oxyge…

Prebiotic Isomaltooligosaccharide Provides an Advantageous Fitness to the Probiotic Bacillus subtilis CU1 Open

Romain Villéger, Émilie Pinault, Karine Vuillier-Devillers, Karine Grenier, Cornelia Landolt , et al. · 2022

Bacillus subtilis CU1 is a probiotic strain with beneficial effects on immune health in elderly subjects and diarrhea. Commercialized under spore form, new strategies to improve the germination, fitness and beneficial effects of the probio…

Synthesis and Investigation of Flavanone Derivatives as Potential New Anti-Inflammatory Agents Open

Cynthia Sinyeue, Mariko Matsui, Michael Oelgemöller, Frédérique Brégier, Vincent Chaleix , et al. · 2022

Flavonoids are polyphenols with broad known pharmacological properties. A series of 2,3-dihydroflavanone derivatives were thus synthesized and investigated for their anti-inflammatory activities. The target flavanones were prepared through…

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