Vincent U. Gant
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View article: H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells
H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells Open
Background The histone variant H3.3 is enriched at active regulatory elements such as promoters and enhancers in mammalian genomes. These regions are highly accessible, creating an environment that is permissive to transcription factor bin…
View article: Additional file 4 of H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells
Additional file 4 of H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells Open
Additional file 4: Table S3. Pairwise comparison of TF binding activity between WT ESCs and EBs or between WT and H3.3 KO EBs.
View article: Additional file 2 of H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells
Additional file 2 of H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells Open
Additional file 2: Table S1. Pairwise comparison of TF binding activity between WT and H3.3 KO, HIRA KO, ATRX KO and DAXX KO ESCs.
View article: Additional file 5 of H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells
Additional file 5 of H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells Open
Additional file 5: Table S4. Summary of datasets generated or used in this study.
View article: Additional file 3 of H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells
Additional file 3 of H3.3 contributes to chromatin accessibility and transcription factor binding at promoter-proximal regulatory elements in embryonic stem cells Open
Additional file 3: Table S2. Summary of pairwise comparisons of differential expression and binding activity of TFs between WT and H3.3 KO or HIRA KO ESCs.
View article: CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome
CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome Open
View article: Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency
Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency Open
Somatic mutations are rare in pediatric acute myeloid leukemia (pAML), indicating that alternate strategies are needed to identify targetable dependencies. We performed the first enhancer mapping of pAML in 22 patient samples. Generally, p…
View article: ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress Open
View article: ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress Open
ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures. While several studies demonstrate that loss of ATRX…
View article: Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds
Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds Open
Children with Down syndrome have an approximately 10-fold increased risk of developing acute lymphoblastic leukemia and this risk is influenced by inherited genetic variation. Genome-wide association studies have identified IKZF1 as a stro…
View article: An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance
An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance Open
View article: Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome
Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome Open
The authors report the interaction between Down syndrome, a major genetic leukemia predisposition condition, and inherited genetic alleles associated with increased susceptibility to childhood acute lymphoblastic leukemia.
View article: Characterization of the Nodamura virus RNA-dependent RNA polymerase and formation of RNA replication complexes in mammalian cells
Characterization of the Nodamura virus RNA-dependent RNA polymerase and formation of RNA replication complexes in mammalian cells Open
Positive-strand RNA viruses amplify their genomes in membrane-bound structures associated with intracellular membranes and organelles called replication complexes (RCs). Here, we begin to elucidate mechanisms of Nodamura virus (NoV; family…