Vijay K. Sharma
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View article: CT perfusion identified potential treatment opportunities in one in five mild strokes
CT perfusion identified potential treatment opportunities in one in five mild strokes Open
Background Guidelines generally advise against reperfusion therapy in patients with mild stroke (NIHSS ≤ 5) and non-disabling symptoms. However, stroke severity can fluctuate, and clinical scores may not fully capture tissue at risk. Relia…
View article: Seizures after decompressive surgery for cerebral venous thrombosis
Seizures after decompressive surgery for cerebral venous thrombosis Open
Introduction The incidence and outcomes of seizures among patients with severe cerebral venous thrombosis treated with decompressive surgery are unknown as are potential predictors of seizures in these patients. Patients and methods We rep…
View article: Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy
Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy Open
Small fiber neuropathy (SFN) affects small-diameter sensory and autonomic nerve fibers, leading to chronic pain and autonomic dysfunction. While SFN can be associated with diabetes and autoimmune diseases, a significant proportion of cases…
View article: Asian-Pacific Expert Opinion on Patent Foramen Ovale Closure: Review of New Evidence and Focused Update
Asian-Pacific Expert Opinion on Patent Foramen Ovale Closure: Review of New Evidence and Focused Update Open
In 2020, clinical experts from leading Asian-Pacific cardiology and neurology centers published an expert opinion and consensus statement on transcatheter patent foramen ovale (PFO) closure for patients in the Asian-Pacific region. Given r…
View article: Large subfoveal pigment epithelial detachment causing macular hole formation: Surgical approach
Large subfoveal pigment epithelial detachment causing macular hole formation: Surgical approach Open
Subfoveal pigment epithelial detachments (PEDs) have been reported to develop full-thickness macular hole (FTMH). The response to treatment has been varied in different reports, with most cases having persistent PED even after successful s…
View article: Evaluation of physical properties, colour quest and sensory of sorghum-based nutribar
Evaluation of physical properties, colour quest and sensory of sorghum-based nutribar Open
View article: Transcranial Doppler Screening in Sickle Cell Disease: Insights from a Regional Study in Karnataka, India
Transcranial Doppler Screening in Sickle Cell Disease: Insights from a Regional Study in Karnataka, India Open
Sickle cell disease (SCD), a hereditary blood disorder in India, disproportionately affects Adivasi communities burdened by socio-economic and systemic inequities. Stroke, a severe complication of SCD, is underexplored in Indian population…
View article: Yoga Mudras and Physiological Benefits: A Narrative Review of Their Role in Cardiopulmonary Function
Yoga Mudras and Physiological Benefits: A Narrative Review of Their Role in Cardiopulmonary Function Open
Yoga Mudras, specific hand gestures used in conjunction with pranayama and meditation, are believed to influence physiological functions, particularly those related to the circulatory and respiratory systems. This narrative review explores…
View article: Patterns of neuropsychological deficits and memory profile in ischaemic stroke subtypes in an Asian cohort
Patterns of neuropsychological deficits and memory profile in ischaemic stroke subtypes in an Asian cohort Open
Due to the heterogenous nature of stroke, cognitive impairments differ widely across subtypes. This study explored neuropsychological patterns and memory profiles of Asian patients with different ischaemic stroke subtypes. Participants inc…
View article: Risk Assessment of Brucella Exposure Through Raw Milk Consumption in India: One Health Implications and Control Strategies
Risk Assessment of Brucella Exposure Through Raw Milk Consumption in India: One Health Implications and Control Strategies Open
Brucellosis is a zoonotic disease with significant public health implications. Understanding the risks of consuming unpasteurized (raw) milk is critical for effective control measures. A quantitative risk assessment was conducted to estima…
View article: Objective and subjective outcomes following implantable collamer lens (ICL) implantation for the correction of myopia
Objective and subjective outcomes following implantable collamer lens (ICL) implantation for the correction of myopia Open
BACKGROUND: Implantable collamer lens (ICL) implantation has gained popularity as a surgical option for the correction of high myopia. This study aimed to evaluate the visual outcomes, patient satisfaction, and safety of ICL implantation b…
View article: Timing of starting anticoagulation following decompressive surgery for cerebral vein and sinus thrombosis: An observational study
Timing of starting anticoagulation following decompressive surgery for cerebral vein and sinus thrombosis: An observational study Open
Background: Anticoagulation is the mainstay acute therapy for cerebral venous thrombosis (CVT). Decompressive surgery is required in a small minority of patients with large parenchymal lesions and impending herniation, which requires a tem…
View article: ASSOCIATION BETWEEN SCREEN TIME RELATED MUSCULOSKELETAL SYMPTOM AMONG DESK JOB EMPLOYEES: A CROSS-SECTIONAL STUDY
ASSOCIATION BETWEEN SCREEN TIME RELATED MUSCULOSKELETAL SYMPTOM AMONG DESK JOB EMPLOYEES: A CROSS-SECTIONAL STUDY Open
View article: Embolization of Middle Meningeal Artery in Patients with Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis of Randomized-Controlled Clinical Trials
Embolization of Middle Meningeal Artery in Patients with Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis of Randomized-Controlled Clinical Trials Open
Background: Chronic subdural hematoma (cSDH) is a common neurosurgical condition, particularly among elderly patients. Middle meningeal artery (MMA) embolization has emerged as a minimally invasive adjunctive treatment aimed at reducing re…
View article: Acute Blood Pressure Lowering and Risk of Ischemic Lesions on MRI After Intracerebral Hemorrhage
Acute Blood Pressure Lowering and Risk of Ischemic Lesions on MRI After Intracerebral Hemorrhage Open
Importance Diffusion-weighted imaging (DWI) lesions have been demonstrated in patients with subacute intracerebral hemorrhage (ICH), suggesting ischemic injury, which may be related to blood pressure (BP) reduction. Objective To test the h…
View article: Return to Work After Ischemic Stroke in Young Adults: A Multicenter Cohort Study, Systematic Review, and Meta‐Analysis
Return to Work After Ischemic Stroke in Young Adults: A Multicenter Cohort Study, Systematic Review, and Meta‐Analysis Open
Background Ischemic stroke incidence in young adults is increasing globally, with return to work (RTW) a key rehabilitation goal. We aimed to assess the overall proportions of and factors associated with RTW following young adult ischemic …
View article: 16P Development and characterization of peptide-drug conjugates for targeted therapy in small cell lung cancer
16P Development and characterization of peptide-drug conjugates for targeted therapy in small cell lung cancer Open
View article: Impact of number of passes and futile reperfusion in basilar artery occlusion acute ischaemic stroke
Impact of number of passes and futile reperfusion in basilar artery occlusion acute ischaemic stroke Open
Introduction: Mechanical thrombectomy (MT) is the standard of care in anterior circulation large vessel occlusion. A vital modifiable factor is successful reperfusion. While multiple passes improve the rates of successful reperfusion, prev…
View article: Risk Assessment of Brucella Exposure Through Raw Milk Consumption in India; One Health Implications and Control Strategies
Risk Assessment of Brucella Exposure Through Raw Milk Consumption in India; One Health Implications and Control Strategies Open
View article: Comparative study on physico-chemical properties of litchi seed starch using different extraction methods
Comparative study on physico-chemical properties of litchi seed starch using different extraction methods Open
View article: Microembolic signal detection in acute ischemic stroke: Clinical relevance and impact on treatment individualization—A narrative review
Microembolic signal detection in acute ischemic stroke: Clinical relevance and impact on treatment individualization—A narrative review Open
Background Microembolic signals (MES) can be detected using transcranial Doppler (TCD) ultrasound in several clinical scenarios, including acute ischemic stroke (AIS). This narrative review aims to provide insights into their role in AIS p…
View article: The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice
The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice Open
Bile acids are liver-derived signaling molecules that can be found in the brain, but their role there remains largely unknown. We found increased brain chenodeoxycholic acid (CDCA) in mice with absent 12α-hydroxylase (Cyp8b1), a bile acid …
View article: Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke
Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke Open
ClinicalTrials.gov (NCT01422616).
View article: Numerical Investigation of Increasing-Decreasing Stepped Micro Pin Fin Heat Sink Having Various Arrangements
Numerical Investigation of Increasing-Decreasing Stepped Micro Pin Fin Heat Sink Having Various Arrangements Open
The ongoing trend of miniaturization of electronic devices, including computer processors, high-speed servers and micro-electro-mechanical system devices, should go hand in hand with their improved performance. However, managing heat remai…
View article: Multi-Modal Assessment of Cerebral Hemodynamics in Resuscitated Out-of-Hospital Cardiac Arrest Patients: A Case-Series
Multi-Modal Assessment of Cerebral Hemodynamics in Resuscitated Out-of-Hospital Cardiac Arrest Patients: A Case-Series Open
We assessed the feasibility of concurrent monitoring of cerebral hemodynamics in adult, comatose out-of-hospital cardiac arrest (OHCA) patients admitted to the National University Heart Centre Singapore from October 2021 to August 2023. Pa…
View article: Kitaev physics in the two-dimensional magnet <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>NiPSe</mml:mi><mml:mn>3</mml:mn></mml:msub></mml:math>
Kitaev physics in the two-dimensional magnet Open
The Kitaev interaction, found in candidate materials such as α−RuCl3, occurs through the metal (M)-ligand (X)-metal (M) paths of the edge-sharing octahedra because the large spin-orbit coupling (SOC) on the metal atoms activates directiona…
View article: Validation of the transcranial Doppler rescue criteria for mechanical thrombectomy
Validation of the transcranial Doppler rescue criteria for mechanical thrombectomy Open
Background and Purpose Transcranial Doppler (TCD) identifies acute stroke patients with arterial occlusion where treatment may not effectively open the blocked vessel. This study aimed to examine the clinical utility and prognostic value o…
View article: Effect of Hemolysis on Serum Markers of Liver Function
Effect of Hemolysis on Serum Markers of Liver Function Open
Introduction Samples received in the laboratory are often rejected because of visible hemolysis. Every laboratory has protocols on whether to accept or reject hemolyzed samples based on tests ordered. The objective of the study was to obse…
View article: Ozil Phacoemulsification Handpiece versus Phacofragmatome in the Management of Dropped Lens Fragments: A Randomized Controlled Trial
Ozil Phacoemulsification Handpiece versus Phacofragmatome in the Management of Dropped Lens Fragments: A Randomized Controlled Trial Open
Purpose In cataract surgery, dislocation of lens fragments into the vitreous cavity is a rare but significant complication. This study compares the effectiveness of the Ozil phacoemulsification handpiece with the traditional phacofragmatom…
View article: Outcomes of Decompressive Surgery for Patients With Severe Cerebral Venous Thrombosis: DECOMPRESS2 Observational Study
Outcomes of Decompressive Surgery for Patients With Severe Cerebral Venous Thrombosis: DECOMPRESS2 Observational Study Open
BACKGROUND: Decompressive neurosurgery is recommended for patients with cerebral venous thrombosis (CVT) who have large parenchymal lesions and impending brain herniation. This recommendation is based on limited evidence. We report long-te…