Thuy Tran
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View article: 567 XTX301, a tumor-activated Interleukin-12 (IL-12), demonstrated IL-12 pharmacology in patients with advanced solid tumors: pharmacodynamic data from first-in-human phase 1 study (NCT05684965)
567 XTX301, a tumor-activated Interleukin-12 (IL-12), demonstrated IL-12 pharmacology in patients with advanced solid tumors: pharmacodynamic data from first-in-human phase 1 study (NCT05684965) Open
View article: Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1
Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1 Open
Macrophage migration inhibitory factor (MIF) is an upstream regulatory cytokine that is associated with advanced disease and poor outcomes in multiple cancer types, including melanoma. We investigated whether anti-MIF therapy could enhance…
View article: Assessment of the Air Environment in Open-Pit Coal Mining Area in Cam Pha Region, Quang Ninh Province
Assessment of the Air Environment in Open-Pit Coal Mining Area in Cam Pha Region, Quang Ninh Province Open
Quang Ninh is the main coal mining province in Vietnam, with open-pit coal mining activities concentrated in the Cam Pha area. Coal mining activities, on the one hand, bring about economic development for the locality, but on the other han…
View article: Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma
Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma Open
Although mRNA technologies have reinvigorated cancer vaccine development, the identification of strong antigens with consistent tumor cell expression and generation of durable antigen-specific CD8+ T cell memory remain key chall…
View article: Factors that increase class I MHC expression may contribute to the development of immune checkpoint inhibitor-induced diabetes
Factors that increase class I MHC expression may contribute to the development of immune checkpoint inhibitor-induced diabetes Open
Immune checkpoint inhibitors (ICIs) have improved survival of patients with cancer, yet they pose risks of immune-related adverse events (irAEs). ICI-induced insulin-dependent diabetes mellitus (ICI-DM) is a life-threatening and life-alter…
View article: Proceedings of the seventh annual Women in Melanoma Conference
Proceedings of the seventh annual Women in Melanoma Conference Open
View article: Pharmacist-led counseling on insulin pens: A pre-post study in Nguyen Tri Phuong Hospital
Pharmacist-led counseling on insulin pens: A pre-post study in Nguyen Tri Phuong Hospital Open
Background: Improper insulin pen use remains a significant barrier to optimal glycemic control, leading to treatment inefficacy and increased risk of complications. This study aimed to evaluate the impact of pharmacist-led counseling on ou…
View article: <scp>MIF</scp> as an oncogenic driver of low‐heterogeneity melanomas
<span>MIF</span> as an oncogenic driver of low‐heterogeneity melanomas Open
Identifying targets involved in tumor evolution and immune escape is an active area of research in oncology. Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory cytokine that promotes transformed cell proliferation…
View article: CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells
CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells Open
CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF binding to CD74 induces a signaling cascade resulting in the release of its cytosolic intracellular domain (CD74-ICD), which regulates trans…
View article: 763 Therapeutic targeting of the MIF/DDT-CD74 axis in head and neck squamous cell carcinoma (HNSCC) murine models
763 Therapeutic targeting of the MIF/DDT-CD74 axis in head and neck squamous cell carcinoma (HNSCC) murine models Open
View article: 571 Dual inhibition of MIF and DDT enhances the efficacy of anti-PD-1 therapy in murine melanoma
571 Dual inhibition of MIF and DDT enhances the efficacy of anti-PD-1 therapy in murine melanoma Open
View article: DeepChaos+: Signal Detection Quality Enhancement of High-Speed DP-16QAM Optical Fiber Communication Based on Chaos Masking Technique with Deep Generative Models
DeepChaos+: Signal Detection Quality Enhancement of High-Speed DP-16QAM Optical Fiber Communication Based on Chaos Masking Technique with Deep Generative Models Open
In long-haul WDM (wavelength division multiplexing) optical communication systems utilizing the DP-16QAM modulation scheme, traditional methods for removing chaos have exhibited poor performance, resulting in a high bit error rate of 10−2 …
View article: Successful percutaneous coronary intervention of left main coronary artery dissection following mechanical aortic valve replacement surgery: a case report and literature review
Successful percutaneous coronary intervention of left main coronary artery dissection following mechanical aortic valve replacement surgery: a case report and literature review Open
Background Iatrogenic left main coronary artery (LMCA) dissection resulting from cardiac surgery is a rare complication. Its early detection is challenging and often poses a significant threat to the patient's life. However, evidence regar…
View article: Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma
Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma Open
Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) have been implicated as drivers of tumor progression across a variety of cancers. Recent evidence suggests MIF as a therapeutic target in immune ch…
View article: MIF and CD74 as Emerging Biomarkers for Immune Checkpoint Blockade Therapy
MIF and CD74 as Emerging Biomarkers for Immune Checkpoint Blockade Therapy Open
Immune checkpoint blockade (ICB) therapy is used to treat a wide range of cancers; however, some patients are at risk of developing treatment resistance and/or immune-related adverse events (irAEs). Thus, there is a great need for the iden…
View article: Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities
Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities Open
Discovered as inflammatory cytokines, MIF and DDT exhibit widespread expression and have emerged as critical mediators in the response to infection, inflammation, and more recently, in cancer. In this comprehensive review, we provide detai…
View article: Vascular mimicry as a facilitator of melanoma brain metastasis
Vascular mimicry as a facilitator of melanoma brain metastasis Open
Melanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of death in melanoma and affect 40–60% of patients with late-stage disease. Therefore, uncovering the m…
View article: Immunotherapy utilization in stage IIIA melanoma: less may be more
Immunotherapy utilization in stage IIIA melanoma: less may be more Open
Background Immunotherapy agents are approved for adjuvant treatment of stage III melanoma; however, evidence for survival benefit in early stage III disease is lacking. Current guidelines for adjuvant immunotherapy utilization in stage III…
View article: An unusual case of edematous uvula
An unusual case of edematous uvula Open
View article: Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US
Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US Open
Importance While immunotherapy is being used in an expanding range of clinical scenarios, the incidence of immunotherapy initiation at the end of life (EOL) is unknown. Objective To describe patient characteristics, practice patterns, and …
View article: Cardiac Arrest Caused by Amniotic Fluid Embolism: a Report of Two Clinical Cases
Cardiac Arrest Caused by Amniotic Fluid Embolism: a Report of Two Clinical Cases Open
Background: Amniotic fluid embolism (AFE) is a rare and catastrophic obstetric complication that can lead to sudden cardiac arrest, respiratory distress, and disseminated intravascular coagulation. Recognizing and managing this condition p…
View article: 830 Inhibition of macrophage migration inhibitory factor (MIF) to overcome immune checkpoint resistance in melanoma
830 Inhibition of macrophage migration inhibitory factor (MIF) to overcome immune checkpoint resistance in melanoma Open
Background Activation of stimulator of interferon genes (STING) has shown great potential to enhance antitumor immunity. Several synthetic STING agonists have been tested preclinically and in the clinic. However, these molecules are suscep…
View article: GNAQ-mutated primary subcutaneous blue melanoma arising in naevus of Ota presenting as a skin-coloured forehead mass
GNAQ-mutated primary subcutaneous blue melanoma arising in naevus of Ota presenting as a skin-coloured forehead mass Open
View article: The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma
The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma Open
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treat…
View article: Lenvatinib or anti-VEGF in combination with anti–PD-1 differentially augments antitumor activity in melanoma
Lenvatinib or anti-VEGF in combination with anti–PD-1 differentially augments antitumor activity in melanoma Open
Targeting tumor-associated blood vessels to increase immune infiltration may enhance treatment effectiveness, yet limited data exist regarding anti-angiogenesis effects on the tumor microenvironment (TME). We hypothesized that dual targeti…
View article: Current diagnosis and management of cardiac melanoma: a case series and review
Current diagnosis and management of cardiac melanoma: a case series and review Open
Malignant melanoma is believed to have the highest rate of cardiac metastasis of any cancer based on autopsy studies, but descriptions of clinical findings, diagnosis, and treatment remain lacking. In particular, the use of immunotherapy h…
View article: Assessing the impact of climate change on Ha Tu coal mine, Quang Ninh province
Assessing the impact of climate change on Ha Tu coal mine, Quang Ninh province Open
Climate change has been affecting the socio-economic life of Quang Ninh province in general, and the coal mining activities of many companies, including Ha Tu Coal Joint Stock Company in particular. By the methods of collection, synthesis,…
View article: Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma
Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma Open
View article: Coupled fibromodulin and SOX2 signaling as a critical regulator of distant metastasis initiation in melanoma
Coupled fibromodulin and SOX2 signaling as a critical regulator of distant metastasis initiation in melanoma Open
We aimed to study mechanisms controlling the transition from dormant to clinically relevant brain metastases, a critical process responsible for the majority of melanoma deaths. To this end, we developed in vivo models that accurately mimi…
View article: Merkel Cell Carcinoma: Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally
Merkel Cell Carcinoma: Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally Open
Background Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin. Our report describes the evolution of management and characteristics associated with recurrence, disease-specific survival (DSS) and overall surv…