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View article: Nasopharyngeal Proteomic Profiles from Patients Hospitalized Due to COVID-19 in Manaus, Amazonas, Brazil
Nasopharyngeal Proteomic Profiles from Patients Hospitalized Due to COVID-19 in Manaus, Amazonas, Brazil Open
This study investigated proteomic differences in nasopharyngeal swabs of SARS-CoV-2-infected patients from Manaus (Brazil) who were hospitalized during the devastating first wave of the COVID-19 pandemic, before the emergence of the deadly…
View article: A APRENDIZAGEM NO CONTEXTO DA EDUCAÇÃO INCLUSIVA: CENÁRIOS E PERSPECTIVAS
A APRENDIZAGEM NO CONTEXTO DA EDUCAÇÃO INCLUSIVA: CENÁRIOS E PERSPECTIVAS Open
A Educação Inclusiva não é apenas uma premissa legal, mas um imperativo ético e social que exige a contínua reavaliação das nossas práticas pedagógicas. É nesse contexto de desafios e de urgência por uma escola mais justa e equitativa que …
View article: Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria
Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria Open
Malaria is a highly prevalent infectious disease caused by Plasmodium parasites. Plasmodium intraerythrocytic replication leads to hemolysis-driven intermittent febrile crisis in patients. Additionally, the lysis of unparasitized red blood…
View article: Clinical outcomes of dolutegravir treatment in people living with HIV in Brazil: protocol for the CODE cohort
Clinical outcomes of dolutegravir treatment in people living with HIV in Brazil: protocol for the CODE cohort Open
View article: Clinical outcomes of dolutegravir treatment in people living with HIV in Brazil: protocol for the CODE cohort
Clinical outcomes of dolutegravir treatment in people living with HIV in Brazil: protocol for the CODE cohort Open
View article: Clinical and laboratory profiles of Oropouche virus disease from the 2024 outbreak in Manaus, Brazilian Amazon
Clinical and laboratory profiles of Oropouche virus disease from the 2024 outbreak in Manaus, Brazilian Amazon Open
Background The 2024 Oropouche virus (OROV) outbreak in Brazil raised public health concerns due to its unprecedented rapid spread, high incidence, and potential neurological complications. OROV symptoms overlap with locally endemic arbovir…
View article: Towards Malaria Elimination: A Nationwide Case–Control Study to Assess Risk Factors for Severe Malaria‐Related Deaths in Brazil
Towards Malaria Elimination: A Nationwide Case–Control Study to Assess Risk Factors for Severe Malaria‐Related Deaths in Brazil Open
Objective The objective of this study is to describe malaria‐related deaths and assess their risk factors. Methods This is a case–control study using data from Brazil's Ministry of Health (2011–2020) on malaria‐related deaths (ICD‐10: B50‐…
View article: The cost-effectiveness of tafenoquine following screening with STANDARD™ G6PD screening for the treatment of vivax malaria in the Brazilian Public Health System
The cost-effectiveness of tafenoquine following screening with STANDARD™ G6PD screening for the treatment of vivax malaria in the Brazilian Public Health System Open
View article: Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV
Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV Open
Frailty was associated with markedly higher hazard of MACE. Though frailty did not appear to modify the protective effects of pitavastatin seen in the primary trial, the efficacy in frail PWH remains uncertain due to the limited number of …
View article: IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection
IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection Open
Introduction Malaria remains a significant public health challenge in Brazil, where Plasmodium vivax ( P. vivax ) is the predominant species. Dysregulated immune responses contribute substantially to malaria pathogenesis. Indoleamine 2,3-d…
View article: Navigating parasite antigen genetic diversity in the design of Plasmodium vivax serological exposure markers for malaria
Navigating parasite antigen genetic diversity in the design of Plasmodium vivax serological exposure markers for malaria Open
Background Plasmodium vivax poses a major obstacle to malaria elimination because it can lie dormant in the liver for weeks or months before reactivating and causing a relapse of infection. These dormant forms (hypnozoites) cannot be detec…
View article: Eficácia da isotretinoína, espironolactona e terapias hormonais combinadas na acne feminina e Síndrome dos Ovários Policísticos (SOP)
Eficácia da isotretinoína, espironolactona e terapias hormonais combinadas na acne feminina e Síndrome dos Ovários Policísticos (SOP) Open
Introdução: A Síndrome dos Ovários Policísticos (SOP) é um distúrbio endócrino comum em mulheres, frequentemente associado à acne persistente devido ao hiperandrogenismo e resistência à insulina. O tratamento eficaz requer uma abordagem mu…
View article: Impact of CYP2D6, MAOA, and UGT2B7 genetic variants on recurrence of Plasmodium Vivax in the Brazilian Amazon
Impact of CYP2D6, MAOA, and UGT2B7 genetic variants on recurrence of Plasmodium Vivax in the Brazilian Amazon Open
The biotransformation of primaquine is mediated by cytochrome P-450 (CYP) enzymes and monoamine oxygenase A (MAO-A). Polymorphisms in the genes that encode these enzymes can alter the clinical response of patients with Plasmodium vivax mal…
View article: Decentralization of snakebite antivenom treatment to indigenous community health centers in the Brazilian Amazon: From demand to the first treatment (the SAVING Program)
Decentralization of snakebite antivenom treatment to indigenous community health centers in the Brazilian Amazon: From demand to the first treatment (the SAVING Program) Open
Brazilian antivenoms have excellent efficacy in recovering venom-induced coagulopathy, in addition to having a good safety profile with only 10% of patients experiencing a mild reaction such as urticaria or pruritus. More than 3.5 hundred …
View article: Yellow Fever Virus in Mosquitoes from Rainforest Bordering Manaus, Brazil, 2022
Yellow Fever Virus in Mosquitoes from Rainforest Bordering Manaus, Brazil, 2022 Open
We detected yellow fever virus in Haemagogus mosquitoes collected in 2022 in an Amazon rainforest bordering Manaus, Brazil. The viral genome sequence occupied a basal position within the South American I genotype 1E lineage. Our findings r…
View article: Optimising COVID-19 Episode Identification Using Serology and PCR/Rapid Antigen Testing: Insights from the BRACE Trial
Optimising COVID-19 Episode Identification Using Serology and PCR/Rapid Antigen Testing: Insights from the BRACE Trial Open
Background Accurately identifying COVID-19 episodes was crucial during the pandemic for evaluating interventions. Results from diagnostic tools like PCR, rapid antigen test (RAT) and serology are affected by factors such as timing of tests…
View article: An observational pilot study of an active surveillance tool to enhance pharmacovigilance in Brazil
An observational pilot study of an active surveillance tool to enhance pharmacovigilance in Brazil Open
View article: The 1985 Plasmodium vivax malaria elimination campaign in Santa Catarina, Brazil: the feasibility of using serology amid other integrated tools in the last mile
The 1985 Plasmodium vivax malaria elimination campaign in Santa Catarina, Brazil: the feasibility of using serology amid other integrated tools in the last mile Open
View article: Stabilized designs of the malaria adhesin protein PvRBP2b for use as a potential diagnostic for Plasmodium vivax
Stabilized designs of the malaria adhesin protein PvRBP2b for use as a potential diagnostic for Plasmodium vivax Open
Plasmodium vivax is emerging as the most prevalent species causing malaria outside Africa. Most P. vivax infections are relapses due to the reactivation of the dormant liver stage parasites (hypnozoites). Hypnozoites are a major reservoir …
View article: Association between cytokine and increased risk of death in ART- naïve and ART-non-adherence patients hospitalized with advanced HIV disease
Association between cytokine and increased risk of death in ART- naïve and ART-non-adherence patients hospitalized with advanced HIV disease Open
ART-naïve PLWHA hospitalized with advanced HIV have a higher risk of death. Some immunological markers are possible predictors of death upon hospital admission due to HIV/AIDS, and their levels were found to be increased in post-mortem blo…
View article: Clinical outcomes of Dolutegravir treatment in people living with HIV in Brazil: Protocol for the CODE Cohort
Clinical outcomes of Dolutegravir treatment in people living with HIV in Brazil: Protocol for the CODE Cohort Open
The Clinical Outcomes of Dolutegravir Treatment in People Living with HIV in Brazil (CODE) cohort study is a multicenter, prospective, observational study designed to evaluate the safety and efficacy of Dolutegravir (DTG)-based antiretrovi…
View article: Efeitos da fisioterapia respiratória, reabilitação pulmonar e broncodilatadores no controle da dispneia, qualidade de vida e na redução de exacerbações no DPOC
Efeitos da fisioterapia respiratória, reabilitação pulmonar e broncodilatadores no controle da dispneia, qualidade de vida e na redução de exacerbações no DPOC Open
Introdução: A Doença Pulmonar Obstrutiva Crônica (DPOC) é uma condição inflamatória progressiva que causa limitação irreversível ao fluxo aéreo, impactando negativamente a qualidade de vida. Estratégias terapêuticas incluem broncodilatador…
View article: Safety and Efficacy of 3 Alternative Regimens Against Relapsing <i>Plasmodium vivax</i> Malaria in Glucose 6-Phosphate Dehydrogenase–Deficient Patients in the Brazilian Amazon (ALTPRIM)
Safety and Efficacy of 3 Alternative Regimens Against Relapsing <i>Plasmodium vivax</i> Malaria in Glucose 6-Phosphate Dehydrogenase–Deficient Patients in the Brazilian Amazon (ALTPRIM) Open
Background Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and …
View article: Impact of dengue virus infection on the cytoadherence of Plasmodium vivax-infected erythrocytes
Impact of dengue virus infection on the cytoadherence of Plasmodium vivax-infected erythrocytes Open
BACKGROUND Coinfections of Plasmodium parasites and the dengue virus have been linked to severe disease in some patients. The interactions between these two pathogens, particularly their effects on disease progression, highlight the clinic…
View article: Fluconazole Resistance and Heteroresistance in Cryptococcus spp.: Mechanisms and Implications
Fluconazole Resistance and Heteroresistance in Cryptococcus spp.: Mechanisms and Implications Open
The reference methodology for evaluating antifungal susceptibility is based on determining the minimum inhibitory concentration (MIC), which is the lowest drug concentration capable of inhibiting fungal growth. However, such MIC data are i…
View article: The Cost-Effectiveness of Tafenoquine Following Screening with STANDARDTM G6PD Screening for the Treatment of Vivax Malaria in the Brazilian Public Health System
The Cost-Effectiveness of Tafenoquine Following Screening with STANDARDTM G6PD Screening for the Treatment of Vivax Malaria in the Brazilian Public Health System Open
View article: Smartphone-based retrospective analysis for malaria hotspot detection
Smartphone-based retrospective analysis for malaria hotspot detection Open
View article: Cutaneous cryptococcosis resembling keratoacanthoma
Cutaneous cryptococcosis resembling keratoacanthoma Open
Cutaneous cryptococcosis is a manifestation of systemic cryptococcal infection, characterized by polymorphic skin lesions that can make diagnosis challenging. We report an HIV-positive patient with a solitary facial nodule, initially diagn…
View article: Efficacy and Safety of Dual Therapy with Dolutegravir/Lamivudine in Treatment-Naive Persons with CD4 Counts &lt;200/mm3: 48 Weeks Results of the DOLCE Study
Efficacy and Safety of Dual Therapy with Dolutegravir/Lamivudine in Treatment-Naive Persons with CD4 Counts <200/mm3: 48 Weeks Results of the DOLCE Study Open
View article: Evaluation of the influence of post-vaccination anti-SARS-CoV-2 antibodies on Aedes aegypti infection by DENV-1
Evaluation of the influence of post-vaccination anti-SARS-CoV-2 antibodies on Aedes aegypti infection by DENV-1 Open