Vinod Kumar Nigam
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View article: Improved production of thermostable pectinase from novel Bacillus siamensis (BIOSMNF45) using computational-conventional approach
Improved production of thermostable pectinase from novel Bacillus siamensis (BIOSMNF45) using computational-conventional approach Open
The demand for thermostable pectinase in the global commercial market has expanded progressively at a rapid pace. Many industrial processes are operated at elevated temperatures to break down plant polysaccharides (pectin) owing to the sig…
View article: CHARACTERIZATION OF GUT AND LIVER MICROBIOME ALTERATIONS IN A STREPTOZOTOCIN INDUCED RAT MODEL OF LIVER DAMAGE
CHARACTERIZATION OF GUT AND LIVER MICROBIOME ALTERATIONS IN A STREPTOZOTOCIN INDUCED RAT MODEL OF LIVER DAMAGE Open
Liver cirrhosis or damage in liver cells are well reported in many clinical conditions. However, the participation of microbiota in these conditions is being relatively less explored. The present study aimed to evaluate the changes in micr…
View article: Acute small intestine obstruction caused by migrating gastrostomy foley’s catheter
Acute small intestine obstruction caused by migrating gastrostomy foley’s catheter Open
Acute small intestine obstruction is a common problem and usually caused by adhesions, bands, hernias, volvulus, tumors and foreign bodies. Foreign bodies causing acute intestine obstruction is a rare occurrence. Common foreign bodies are …
View article: Nigam’s scoring system: a reliable and accurate scoring system to diagnose acute appendicitis
Nigam’s scoring system: a reliable and accurate scoring system to diagnose acute appendicitis Open
Background: Acute appendicitis is one of the commonest surgical emergencies. The early diagnosis of acute appendicitis is essential and should be treated by appendicectomy at earliest to avoid complications like perforation and gangrene. V…
View article: Analysis of Steel Structure with Its Beam Column Joint Strength Observation for Steel Alloy Case
Analysis of Steel Structure with Its Beam Column Joint Strength Observation for Steel Alloy Case Open
The analysis of steel structures has become increasingly significant due to their wide application in modern civil, industrial, and high-rise constructions. The performance and stability of such structures are highly influenced by the beha…
View article: Subtotal cholecystectomy: a case series
Subtotal cholecystectomy: a case series Open
Subtotal cholecystectomy is a method of removing most of the gallbladder instead of whole of the gallbladder in case of a difficult gallbladder. The term “subtotal cholecystectomy” was introduced by Morse and Barb. Subtotal cholecystectomy…
View article: Valentino appendix: A case report
Valentino appendix: A case report Open
Duodenal or peptic ulcer is a common problem though the incidence is diminishing now a days, but still it is an important problem and can become life threatening if perforation occurs. Sometimes after perforation the clinical picture in a …
View article: Optimisation, characterization, and biological evaluation of novel exopolysaccharide from <i>Bacillus licheniformis</i> (BITSL006)
Optimisation, characterization, and biological evaluation of novel exopolysaccharide from <i>Bacillus licheniformis</i> (BITSL006) Open
The study investigated production, characterisation, and biological properties of exopolysaccharide (EPS) from a thermophilic bacterium, Bacillus licheniformis using sucrose as a main carbon source at a temperature of 75 °C, resulting in a…
View article: Nigam’s standardization of manual anal dilatation (Lord’s procedure)
Nigam’s standardization of manual anal dilatation (Lord’s procedure) Open
Background: Standardisation of manual anal dilatation. It was a quality improvement study. Patients were admitted in various hospitals of Gurgaon, Haryana, India. Methods: Two hundred thirty-six patients of fissure in ano were treated by m…
View article: Metagenomic analysis of Hot Springs of Surajkund and the exploration of thermostable enzymes from endogenous isolates
Metagenomic analysis of Hot Springs of Surajkund and the exploration of thermostable enzymes from endogenous isolates Open
Hot springs serve as a hub for microbial diversity, the microflora of the hot springs can be a source of numerous biologically important molecules. Extremophile bacteria were isolated from different hot springs of India to investigate thei…
View article: Identification of flavonol synthase gene from M. pinnata and its functional elucidation using cowpea genome
Identification of flavonol synthase gene from M. pinnata and its functional elucidation using cowpea genome Open
Background Flavonoids are a class of key polyphenolic secondary metabolites having various roles in plants, like in growth and development, stress defense, and reproduction. Dihydroflavonols are converted into flavonols by flavonol synthas…
View article: The Modified NICH (Nigam’s Inverted Curtain Hernioplasty) for Inguinal hernia – A foolproof Procedure for Recurrence
The Modified NICH (Nigam’s Inverted Curtain Hernioplasty) for Inguinal hernia – A foolproof Procedure for Recurrence Open
It is a procedure where NICH is modified with basic repair, 2 stitches approximating inguinal ligament with conjoint tendon. Hundred patients were operated between April 2012 to April 2022 by modified NICH technique. All were primary uncom…
View article: Heart rate dynamics in the prediction of coronary artery disease and myocardial infarction using artificial neural network and support vector machine
Heart rate dynamics in the prediction of coronary artery disease and myocardial infarction using artificial neural network and support vector machine Open
Depressed HRV has been suggested to be a marker in the identification of atherosclerotic events. The good accuracy observed in classification between control, CAD, and MI subjects, revealed it to be a non-invasive cost-effective approach i…
View article: Extraction and quantification of acrylic acid from acrylamidase-catalyzed reaction produced by Bacillus tequilensis
Extraction and quantification of acrylic acid from acrylamidase-catalyzed reaction produced by Bacillus tequilensis Open
Asparagus racemosus extract increases the life span in Drosophila melanogaster K. V. Kiran Kumar, K. S. Prasanna, J. S. Ashadevi
View article: Nigam’s scoring system for acute appendicitis with high accuracy surpassing Alvarado scoring system
Nigam’s scoring system for acute appendicitis with high accuracy surpassing Alvarado scoring system Open
Background: Acute appendicitis is one of the most common surgical emergencies. Delay in the treatment of acute appendicitis can result in complications, may be lethal. That’s why the early diagnosis and quick treatment is essential. The di…
View article: The molecular docking and molecular dynamics study of flavonol synthase and flavonoid 3’-monooxygenase enzymes involved for the enrichment of kaempferol
The molecular docking and molecular dynamics study of flavonol synthase and flavonoid 3’-monooxygenase enzymes involved for the enrichment of kaempferol Open
Kaempferol is a natural flavonol that shows many pharmacological properties including anti-inflammatory, antioxidant, anticancer, antidiabetic activities etc. It has been reported in many vegetables, fruits, herbs and medicinal plants. The…
View article: Seat belt syndrome: a case report
Seat belt syndrome: a case report Open
Seat belt syndrome happens when a car meets an accident and person sitting in the car with seat belt on gets abdominal injuries typically, seat belt mark with intestinal injuries and factures of ribs and lumber spine. The abdominal injurie…
View article: Hydrocele of canal of the Nuck: A case report
Hydrocele of canal of the Nuck: A case report Open
Hydrocele of canal of Nuck is a rare disease of females. Canal of Nuck is a patent processus vaginalis in women. It usually gets obstructed but sometimes it can remain patent and forms a hydrocele or hernia in inguinal region. Hydrocele of…
View article: Our experience in treating Fournier’s gangrene at Max Hospital, Gurugram
Our experience in treating Fournier’s gangrene at Max Hospital, Gurugram Open
French venereologist Jean-Alfred Fournier described this gangrene as a fulminant gangrene of the penis and scrotum in young men. He reported five cases in his clinical lectures in 1883 though it was first described by Baurienne in 1764. Fo…
View article: SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns
SARS-CoV-2 transgressing LncRNAs uncovers the known unknowns Open
SARS-CoV-2 harbors many known unknown regions in the form of hypothetical open reading frames (ORFs). Although the mechanisms underlying the disease pathogenesis are not clearly understood, molecules such as long noncoding RNAs (lncRNAs) p…
View article: How To Prevent Inguinodynia - After Tension-Free Inguinal Hernia Repair – Our Experience
How To Prevent Inguinodynia - After Tension-Free Inguinal Hernia Repair – Our Experience Open
Inguinodynia is persistence of pain for more than 3 months after inguinal hernia operation. Chronic pain may be associated with hyperesthesia or hypoesthesia. This pain may be mild, moderate or severe. Inguinodynia may even effect quality …
View article: SEROMA AFTER TENSION-FREE INGUINAL HERNIA REPAIR – OUR EXPERIENCE
SEROMA AFTER TENSION-FREE INGUINAL HERNIA REPAIR – OUR EXPERIENCE Open
Seroma Is a collection of fluid called serum that gets collected at the site of inguinal hernia surgery. It is common after inguinal hernia repair with a mesh. Usually seroma develops after 7 to 10 day of operation but can develop even ear…