Vinod Sundaramoorthy
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View article: Conformational dynamics, RNA binding, and phase separation regulate the multifunctionality of rabies virus P protein
Conformational dynamics, RNA binding, and phase separation regulate the multifunctionality of rabies virus P protein Open
View article: Understanding the interconnected roles of gut microbiota and metabolomic profiles in alcoholic liver disease pathophysiology and their potential for innovative treatment strategies
Understanding the interconnected roles of gut microbiota and metabolomic profiles in alcoholic liver disease pathophysiology and their potential for innovative treatment strategies Open
View article: SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell–derived human neurons
SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell–derived human neurons Open
Sarbecoviruses such as SARS and SARS-CoV-2 have been responsible for two major outbreaks in humans, the latter resulting in a global pandemic. While sarbecoviruses primarily cause an acute respiratory infection, they have been shown to inf…
View article: Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex
Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex Open
Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein (N) in the…
View article: ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation
ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation Open
Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia (FTD). Mutations in the CCNF gene, encoding cyclin F, are present in both spora…
View article: SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell-derived human neurons
SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell-derived human neurons Open
Sarbecoviruses such as SARS and SARS-CoV-2 have been responsible for two major outbreaks in humans, the latter resulting in a global pandemic. While sarbecoviruses primarily cause an acute respiratory infection, they have been shown to inf…
View article: Henipaviruses and lyssaviruses target nucleolar treacle protein and regulate ribosomal <scp>RNA</scp> synthesis
Henipaviruses and lyssaviruses target nucleolar treacle protein and regulate ribosomal <span>RNA</span> synthesis Open
The nucleolus is a common target of viruses and viral proteins, but for many viruses the functional outcomes and significance of this targeting remains unresolved. Recently, the first intranucleolar function of a protein of a cytoplasmical…
View article: Machine Learning Identifies Cellular and Exosomal MicroRNA Signatures of Lyssavirus Infection in Human Stem Cell-Derived Neurons
Machine Learning Identifies Cellular and Exosomal MicroRNA Signatures of Lyssavirus Infection in Human Stem Cell-Derived Neurons Open
Despite being vaccine preventable, rabies (lyssavirus) still has a significant impact on global mortality, disproportionally affecting children under 15 years of age. This neurotropic virus is deft at avoiding the immune system while trave…
View article: Mutant Cyclin F Impedes COPII Vesicle-Mediated ER-Golgi Trafficking and ER-Associated Degradation, Inducing ER Stress and Golgi Fragmentation in ALS/FTD
Mutant Cyclin F Impedes COPII Vesicle-Mediated ER-Golgi Trafficking and ER-Associated Degradation, Inducing ER Stress and Golgi Fragmentation in ALS/FTD Open
Background Mutations in the CCNF gene encoding cyclin F are associated with sporadic and familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, but the underlying pathophysiological mechanisms are unknown. Proper functio…
View article: <i>In vitro</i> characterisation of SARS‐CoV‐2 and susceptibility of domestic ferrets ( <i>Mustela putorius furo</i> )
<i>In vitro</i> characterisation of SARS‐CoV‐2 and susceptibility of domestic ferrets ( <i>Mustela putorius furo</i> ) Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an emerging virus that has caused significant human morbidity and mortality since its detection in late 2019. With the rapid emergence has come an unprecedented programme of v…
View article: Host–Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model
Host–Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model Open
The respiratory Influenza A Viruses (IAVs) and emerging zoonotic viruses such as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pose a significant threat to human health. To accelerate our understanding of the host–pathogen r…
View article: Modelling Lyssavirus Infections in Human Stem Cell-Derived Neural Cultures
Modelling Lyssavirus Infections in Human Stem Cell-Derived Neural Cultures Open
Rabies is a zoonotic neurological infection caused by lyssavirus that continues to result in devastating loss of human life. Many aspects of rabies pathogenesis in human neurons are not well understood. Lack of appropriate ex-vivo models f…
View article: Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies
Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies Open
Neurotropic viral infections continue to pose a serious threat to human and animal wellbeing. Host responses combatting the invading virus in these infections often cause irreversible damage to the nervous system, resulting in poor prognos…
View article: Corrigendum to: Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis
Corrigendum to: Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis Open
View article: Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress
Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress Open
View article: Whole Transcriptome Analysis of Aedes albopictus Mosquito Head and Thorax Post-Chikungunya Virus Infection
Whole Transcriptome Analysis of Aedes albopictus Mosquito Head and Thorax Post-Chikungunya Virus Infection Open
Chikungunya virus (CHIKV) is transmitted by Aedes mosquitoes and causes prolonged arthralgia in patients. After crossing the mosquito midgut barrier, the virus disseminates to tissues including the head and salivary glands. To better under…
View article: Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.
Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Open
View article: Zika virus-induced hyper excitation precedes death of mouse primary neuron
Zika virus-induced hyper excitation precedes death of mouse primary neuron Open
This model of excitotoxicity, in the context of neurotropic virus infection, highlights the significance of neuronal activity recording with microelectrode array and possibility of more than one lethal mechanism after Zika virus infection …
View article: Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF <sup>(cyclin F)</sup> complex
Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF <sup>(cyclin F)</sup> complex Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3–5 years of diagnosis. Recently, we identified dise…
View article: Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy
Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy Open
View article: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking Open
View article: Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis
Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis Open
The Authors have identified that the 4% input control blot for the immunoprecipitation presented in Figure 1C was from β-actin blot obtained from the same set of samples, but from a different experiment. Due to the strong resemblance betwe…
View article: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking (vol 12, 3579, 2014)
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking (vol 12, 3579, 2014) Open
The authors have identified that the image of internalised TrKB receptor control and siRNA (top panel) in Figure 5E was presented incorrectly. They provide here a new corrected image, which it can be seen is very similar to the incorrect i…
View article: CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia Open
View article: PDI co-precipitates with TDP-43 and is increased in mutant TDP-43 transgenic mouse spinal cords.
PDI co-precipitates with TDP-43 and is increased in mutant TDP-43 transgenic mouse spinal cords. Open
(A) Co-immunoprecipitation of wildtype and mutant Q331K TDP-43-mCherry from Neuro2a cell lysates using an anti-PDI antibody followed by TDP-43 immunoblot. Control immunoprecipitations were performed using untransfected (Untrans) or …
View article: Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences
Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences Open
Amyotrophic Lateral Sclerosis (ALS) is an invariably fatal neurodegenerative disorder, which specifically targets motor neurons in the brain, brain stem and spinal cord. Whilst the etiology of ALS remains unknown, fragmentation of the Golg…
View article: ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1
ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1 Open
View article: Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis
Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder primarily affecting motor neurons. Mutations in optineurin cause a small proportion of familial ALS cases, and wild-type (WT) optineurin is misfolded and forms inclu…