Vipul Kumar
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View article: Recognizing amino acid sidechains in a medium‐resolution cryo‐electron density map
Recognizing amino acid sidechains in a medium‐resolution cryo‐electron density map Open
Building an accurate atomic structure model of a protein into a cryo‐electron microscopy (cryo‐EM) map at worse than 3 Å resolution is difficult. To facilitate this task, we devised a method for assigning the amino acid residue sequence to…
View article: Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression
Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression Open
Histologic variant (HV) subtypes of bladder cancer are clinically aggressive tumors that are more resistant to standard therapy compared to conventional urothelial carcinoma (UC). Little is known about the transcriptional programs that acc…
View article: Recognizing amino acid sidechains in a medium resolution cryo-electron density map
Recognizing amino acid sidechains in a medium resolution cryo-electron density map Open
Building an accurate atomic structure model of a protein into a cryo-electron microscopy (cryo-EM) map at worse than 3 Angstrom resolution is difficult. To facilitate this task, we devised a method for assigning the amino acid residue sequ…
View article: HER2 overexpression in urothelial carcinoma with <i>GATA3</i> and <i>PPARG</i> copy number gains
HER2 overexpression in urothelial carcinoma with <i>GATA3</i> and <i>PPARG</i> copy number gains Open
HER2, encoded by the ERBB2 gene, is an important druggable driver of human cancer gaining increasing importance as a therapeutic target in urothelial carcinoma (UC). The genomic underpinnings of HER2 overexpression in ERBB2 nonamplified UC…
View article: Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state
Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state Open
Histologic variant (HV) subtypes of bladder cancer are clinically aggressive tumors that are more resistant to standard therapy compared to conventional urothelial carcinoma (UC). Little is known about the transcriptional programs that acc…
View article: Initial Experience with<sup>68</sup>Ga-FAP-2286 PET Imaging in Patients with Urothelial Cancer
Initial Experience with<sup>68</sup>Ga-FAP-2286 PET Imaging in Patients with Urothelial Cancer Open
Improved imaging modalities are needed to accurately stage patients with muscle-invasive bladder cancer (MIBC) and metastatic urothelial carcinoma. Imaging with small-molecule ligands or inhibitors of fibroblast activation protein (FAP) is…
View article: Computational analysis of RNA methyltransferase Rv3366 as a potential drug target for combating drug-resistant Mycobacterium tuberculosis
Computational analysis of RNA methyltransferase Rv3366 as a potential drug target for combating drug-resistant Mycobacterium tuberculosis Open
Mycobacterium tuberculosis ( M.tb ) remains a formidable global health threat. The increasing drug resistance among M.tb clinical isolates is exacerbating the current tuberculosis (TB) burden. In this study we focused on identifying novel …
View article: Detecting Presence of Tarsal Tunnel Syndrome in Type II Diabetic Patients using Clinical, Radiological and Electrodiagnostic Studies: A Cross-sectional Study
Detecting Presence of Tarsal Tunnel Syndrome in Type II Diabetic Patients using Clinical, Radiological and Electrodiagnostic Studies: A Cross-sectional Study Open
Introduction: Diabetic foot is one of the most devastating complications of diabetes and is the leading cause of lower limb amputations. Patients with a long-standing history of diabetes mellitus often experience symptoms of pain, burning …
View article: Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer
Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer Open
Background Enfortumab vedotin (EV) is an antibody-drug conjugate approved for patients with treatment-refractory advanced urothelial carcinoma (aUC), however data on biomarkers of response is lacking. Methods We retrospectively identified …
View article: Exploring the Impact of Peer Pressure and Purchase Intention on Consumer Attitude towards Counterfeit Products: An Extension of Theory of Planned Behaviour
Exploring the Impact of Peer Pressure and Purchase Intention on Consumer Attitude towards Counterfeit Products: An Extension of Theory of Planned Behaviour Open
Abstract: Counterfeit fashion accessories, clothes, luxury products are available, accessible in marketplaces and a big concern in India. Counterfeiting impacts the original manufacturers brand value, image and revenue. While supply of cou…
View article: Consumer Attitude towards Counterfeit Products: An Extension of Theory of Planned Behaviour
Consumer Attitude towards Counterfeit Products: An Extension of Theory of Planned Behaviour Open
Abstract: Counterfeit fashion accessories, clothes, luxury products are available, accessible in marketplaces and a big concern in India. Counterfeiting impacts the original manufacturers brand value, image and revenue. While supply of cou…
View article: Computational and experimental evidence of the <scp>anti‐COVID</scp>‐19 potential of honeybee propolis ingredients, caffeic acid phenethyl ester and artepillin c
Computational and experimental evidence of the <span>anti‐COVID</span>‐19 potential of honeybee propolis ingredients, caffeic acid phenethyl ester and artepillin c Open
Appendix S1. Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the co…
View article: Speech Emotion Recognition Using Deep Learning
Speech Emotion Recognition Using Deep Learning Open
Emotional state identification based on analysis of vocalisations is a challenging subject in the field of HumanComputer Interaction (HCI). In the research that has been done on speech emotion recognition (SER). A wide range of research ap…
View article: A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms
A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms Open
Withaferin A (Wi-A) and Caffeic Acid Phenethyl Ester (CAPE) are the bioactive ingredients of Ashwagandha (Withania somnifera) and propolis, respectively. Both of these natural compounds have been shown to possess anticancer activity. In th…
View article: Insights into the potential of withanolides as Phosphodiesterase-4 (PDE4D) inhibitors
Insights into the potential of withanolides as Phosphodiesterase-4 (PDE4D) inhibitors Open
Medicinal herbs have been used as traditional medicines for centuries. The molecular mechanism of action of their bioactive molecules against various diseases or therapeutic targets is still being explored. Here, the active compounds (with…
View article: Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53Ser46 mutant
Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53Ser46 mutant Open
Genetic mutations in p53 are frequently associated with many types of cancers that affect its stability and activity through multiple ways. The Ser46 residue present in the transactivation domain2 (TAD2) domain of p53 undergoes phosphoryla…
View article: 1105. Population Pharmacokinetic Analyses for Tebipenem After the Administration of Tebipenem Pivoxil Hydrobromide
1105. Population Pharmacokinetic Analyses for Tebipenem After the Administration of Tebipenem Pivoxil Hydrobromide Open
Background Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is an oral prodrug that is converted to tebipenem (TBP), the active moiety. TBP is a carbapenem with activity against multidrug-resistant Gram-negative pathogens, including extended-sp…
View article: Computational and <i>in vitro</i> experimental analyses of the Anti-COVID-19 potential of Mortaparib and MortaparibPlus
Computational and <i>in vitro</i> experimental analyses of the Anti-COVID-19 potential of Mortaparib and MortaparibPlus Open
COVID-19 pandemic caused by SARS-CoV-2 virus has become a global health emergency. Although new vaccines have been generated and being implicated, discovery and application of novel preventive and control measures are warranted. We aimed t…
View article: Computational and <i>in vitro</i> experimental analyses of the anti-COVID-19 potential of Mortaparib and MortaparibPlus
Computational and <i>in vitro</i> experimental analyses of the anti-COVID-19 potential of Mortaparib and MortaparibPlus Open
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has become a global health emergency. Although new vaccines have been generated and being implicated, discovery and a…
View article: Possible Link between Higher Transmissibility of Alpha, Kappa and Delta Variants of SARS-CoV-2 and Increased Structural Stability of Its Spike Protein and hACE2 Affinity
Possible Link between Higher Transmissibility of Alpha, Kappa and Delta Variants of SARS-CoV-2 and Increased Structural Stability of Its Spike Protein and hACE2 Affinity Open
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak in December 2019 has caused a global pandemic. The rapid mutation rate in the virus has created alarming situations worldwide and is being attributed to the false ne…
View article: Outcome of various modalities of management of distal tibia fracture
Outcome of various modalities of management of distal tibia fracture Open
Background: Distal tibial fractures represent less than 7% of all tibial fractures. The present study was conducted to compare outcome of various modalities of management of distal tibia fractures. Materials & Methods: 45 distal tibia frac…
View article: Distal tibial extra-articular fractures fixed with locking compression plate using MIPO technique: A clinical study
Distal tibial extra-articular fractures fixed with locking compression plate using MIPO technique: A clinical study Open
Background: Distal tibial fractures are one of the most complex injuries around the ankle joint, accounting for approximately 7% of all tibial fractures. The present study was conducted to assess distal tibial extra-articular fractures fix…
View article: Possible link between higher transmissibility of B.1.617 and B.1.1.7 variants of SARS-CoV-2 and increased structural stability of its spike protein and hACE2 affinity
Possible link between higher transmissibility of B.1.617 and B.1.1.7 variants of SARS-CoV-2 and increased structural stability of its spike protein and hACE2 affinity Open
The Severe Acute syndrome corona Virus 2 (SARS-CoV-2) outbreak in December 2019 has caused a global pandemic. The rapid mutation rate in the virus has caused alarming situations worldwide and is being attributed to the false negativity in …
View article: COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays
COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays Open
SARS-CoV-2 outbreak in China in December 2019 and its spread as worldwide pandemic has been a major global health crisis. Extremely high infection and mortality rate has severely affected all sectors of life and derailed the global economy…
View article: Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications
Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications Open
SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus 2) has accumulated multiple mutations during its global circulation. Recently, three SARS-CoV-2 lineages, B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1), have emerged in …
View article: Identification and Characterization of MortaparibPlus—A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms
Identification and Characterization of MortaparibPlus—A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms Open
p53 has an essential role in suppressing the carcinogenesis process by inducing cell cycle arrest/apoptosis/senescence. Mortalin/GRP75 is a member of the Hsp70 protein family that binds to p53 causing its sequestration in the cell cytoplas…