Hrishikesh Kumar
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View article: Analytical Validation of a Pan-Cancer Next-Generation Sequencing Assay for In-House Liquid Biopsy Testing
Analytical Validation of a Pan-Cancer Next-Generation Sequencing Assay for In-House Liquid Biopsy Testing Open
Liquid biopsy assays are transforming precision oncology by providing a less invasive alternative to tissue biopsies. These assays screen for tumor genetic alterations in circulating free DNA, which typically requires detecting variants at…
View article: Diagnostic Accuracy of CSF Tap-Test Parameters in Predicting Shunt Responsiveness in Normal Pressure Hydrocephalus: A Cohort Study
Diagnostic Accuracy of CSF Tap-Test Parameters in Predicting Shunt Responsiveness in Normal Pressure Hydrocephalus: A Cohort Study Open
Background The cerebrospinal fluid tap test (CSF-TT) is widely used as an ancillary test to select patients with idiopathic Normal Pressure Hydrocephalus (iNPH) for surgical management; however, its diagnostic utility remains unclear. We e…
View article: CSF Tap Test Parameters and Short-Term Outcomes in operated and non-operated patients with idiopathic Normal Pressure Hydrocephalus: A Cohort Study
CSF Tap Test Parameters and Short-Term Outcomes in operated and non-operated patients with idiopathic Normal Pressure Hydrocephalus: A Cohort Study Open
Background Normal Pressure hydrocephalus (NPH) is treated by ventriculoperitoneal shunting. The cerebrospinal fluid tap test (CSF-TT) is widely used to identify candidates for shunt surgery in idiopathic NPH (iNPH). This study aimed to com…
View article: The claudin-like molecule CLC-3 regulates neuromuscular function in <i>Caenorhabditis elegans</i> by modulating cholinergic signalling
The claudin-like molecule CLC-3 regulates neuromuscular function in <i>Caenorhabditis elegans</i> by modulating cholinergic signalling Open
Cell adhesion molecules (CAMs play important roles in neurons, contributing to nervous system development, synapse formation, and activity-dependent plasticity. Claudins, the cell-adhesion molecules known for their roles at tight junctions…
View article: Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study
Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study Open
Background Parkinson's disease (PD) phenotype may vary with genetic, ethno‐geographic, cultural, and environmental factors. Objectives The aim was to develop a clinical database of PD in India and assess the influence of age‐at‐onset (AAO)…
View article: A Study on Ti‐Nb Alloys with Different Composition for Orthopedic Application Using MD Simulations and Experiments
A Study on Ti‐Nb Alloys with Different Composition for Orthopedic Application Using MD Simulations and Experiments Open
The nanoindentation behavior of Ti‐Nb alloy with varying compositions (5–25 wt.% of Nb in Ti) is investigated using molecular dynamics simulations. Single crystals of different Ti‐Nb alloys are generated to perform nanoindentation simulati…
View article: Association of a kinematic measure of upper limb reaching and StartReact in chronic hemiparetic stroke
Association of a kinematic measure of upper limb reaching and StartReact in chronic hemiparetic stroke Open
Background After stroke, recovery of upper limb reaching movements may partly depend on the level of activation of the reticulospinal tract (RST), but few clinical studies have explored this. Here we examined the association between the st…
View article: Praying mantis to cock-walk: Clinical signs in movement disorders derived from animals
Praying mantis to cock-walk: Clinical signs in movement disorders derived from animals Open
Multiple clinical signs in the field of movement disorders are inspired by the animal kingdom. We aimed to summarize such clinical signs to aid in their clinical recognition. A list of animal-derived clinical signs, compiled from the autho…
View article: Whole Genome Sequencing-Based Diagnosis of Spinocerebellar Ataxia Type 3 Repeat Expansion Neuromuscular Disorders in an Undiagnosed Patient: Breaking Past Diagnostic Boundaries
Whole Genome Sequencing-Based Diagnosis of Spinocerebellar Ataxia Type 3 Repeat Expansion Neuromuscular Disorders in an Undiagnosed Patient: Breaking Past Diagnostic Boundaries Open
Background: Spinocerebellar ataxia type 3 (SCA3) is a neuromuscular disorder (NMD) that is a complicated and progressive genetic disorder. SCA3 is predominantly caused by repeat expansions (REs) of short tandem repeats (STRs). SCA3 is caus…
View article: Deciphering the Genetic Architecture of Parkinson’s Disease in India
Deciphering the Genetic Architecture of Parkinson’s Disease in India Open
The genomic landscape of the Indian population, particularly for age-related disorders like Parkinson’s disease (PD) remains underrepresented in global research. Genetic variability in PD has been studied predominantly in European populati…
View article: A novel method to assess motor planning deficits in patients with Parkinson’s disease and mild cognitive impairment
A novel method to assess motor planning deficits in patients with Parkinson’s disease and mild cognitive impairment Open
It is well established that patients with Parkinson’s disease (PD) show deficits with movement execution, however experiences of motor planning dysfunction, and how they relate to the severity of motor symptoms, remains unclear. To investi…
View article: Pointing index posture in progressive supranuclear palsy and corticobasal syndrome
Pointing index posture in progressive supranuclear palsy and corticobasal syndrome Open
Dear Sir, Focal dystonia is commonly associated with atypical parkinsonism. The topographical distribution of dystonia in these cases often serves as clinical indicators for the diagnosis of conditions such as blepharospasm and retrocollis…
View article: Mitochondrial ataxia - Unravelling the puzzle
Mitochondrial ataxia - Unravelling the puzzle Open
Primary mitochondrial diseases (PMDs) can be caused by a defect in any of the mitochondrial metabolic pathways, due to mitochondrial or nuclear DNA mutations, or occurring de novo. Ataxia is one of the most common presentations in mitochon…
View article: Palmaris brevis spasm syndrome: The treatable hypothenar dimpling
Palmaris brevis spasm syndrome: The treatable hypothenar dimpling Open
Palmaris brevis spasm syndrome is a rare disorder, mostly reported with occupational overuse of a computer keyboard, mouse, pipette, and vibratory tools or after the use of arm braces. Rarely, it can be spontaneous. It is clinically charac…
View article: Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease
Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease Open
Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled trial we explored the role of nVNS i…
View article: Neurostimulation for Advanced Parkinson Disease and Quality of Life at 5 Years
Neurostimulation for Advanced Parkinson Disease and Quality of Life at 5 Years Open
Importance Deep brain stimulation of the subthalamic nucleus (STN-DBS) improves quality of life (QOL) in patients with advanced Parkinson disease (PD). However, controlled studies with more than 3 years of follow-up are lacking. Objective …
View article: The Genetic Drivers of Juvenile, Young, and Early‐Onset Parkinson's Disease in India
The Genetic Drivers of Juvenile, Young, and Early‐Onset Parkinson's Disease in India Open
Background Recent studies have advanced our understanding of the genetic drivers of Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and the latest PD genome‐wide association study (GWAS) identifi…
View article: Biomass Gasification and Applied Intelligent Retrieval in Modeling
Biomass Gasification and Applied Intelligent Retrieval in Modeling Open
Gasification technology often requires the use of modeling approaches to incorporate several intermediate reactions in a complex nature. These traditional models are occasionally impractical and often challenging to bring reliable relation…
View article: COVID-19 and De Novo Movement Disorders: Lessons Learned So Far
COVID-19 and De Novo Movement Disorders: Lessons Learned So Far Open
Movement Disorder Centre, Institute of Neurosciences Kolkata, 185, Acharya Jagadish Chandra Bose Rd, Elgin, Kolkata, West Bengal, India Address for correspondence: Dr. Jacky Ganguly, Movement Disorder Centre, Institute of Neurosciences Kol…