Vinothini Rajeeve
YOU?
Author Swipe
View article: An AGO2 adaptor expands the functional and evolutionary reach of microRNA targeting
An AGO2 adaptor expands the functional and evolutionary reach of microRNA targeting Open
Current models of microRNA (miRNA) silencing posit that RNA-sequence rules are sufficient for canonical targeting of mRNAs by Argonaute 2 (AGO2), the central protein of the miRNA-induced silencing complex (miRISC). Using chimeric eCLIP in …
View article: Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer
Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer Open
View article: Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer
Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer Open
The tumor extracellular matrix (ECM) is increasingly recognized as a key driver of immune suppression and therapy resistance in cancer. However, the specific ECM components and mechanisms that create this immunosuppressive environment rema…
View article: SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2
SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2 Open
Activating mutations of Src homology-2 domain-containing protein tyrosine phosphatase-2 (Shp2) cause multiple childhood conditions for which there is an unmet therapeutic need, including juvenile myelomonocytic leukemia (JMML) and Noonan s…
View article: Author response: RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
Author response: RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
View article: RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS–p110α signalling pathway, known for its involvement in various biological p…
View article: Phosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells
Phosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells Open
View article: RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological p…
View article: Author response: RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
Author response: RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
View article: RAS-PI3K Pathway in CAFs Shapes Physicochemical Properties of Tumor ECM to Impact Tumor Progression
RAS-PI3K Pathway in CAFs Shapes Physicochemical Properties of Tumor ECM to Impact Tumor Progression Open
Cancer-associated fibroblasts (CAFs) are key regulators of the tumor microenvironment, promoting tumor progression through extracellular matrix (ECM) remodeling and paracrine signaling, but the signaling pathways controlling CAF function r…
View article: RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages are crucial in the body's inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological p…
View article: RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages are crucial in the body's inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological p…
View article: Author response: RAS-p110a signalling in macrophages is required for effective inflammatory response and resolution of inflammation
Author response: RAS-p110a signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
View article: RAS-p110a signalling in macrophages is required for effective inflammatory response and resolution of inflammation
RAS-p110a signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological p…
View article: HMMR is an independent prognostic indicator in neuroblastoma and loss of HMMR suppresses cell proliferation, migration and clonogenicity.
HMMR is an independent prognostic indicator in neuroblastoma and loss of HMMR suppresses cell proliferation, migration and clonogenicity. Open
Purpose Neuroblastoma is a childhood cancer with poor survival rates. Approximately 75% of tumours have no identified oncogenic driver and here our aim was for the first time to investigate whether HMMR, a protein with hyaluronic acid (HA)…
View article: 139P Rewiring of cis-regulatory and kinase signalling networks in acalabrutinib-resistant ABC DLBCL cells
139P Rewiring of cis-regulatory and kinase signalling networks in acalabrutinib-resistant ABC DLBCL cells Open
View article: RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages are crucial in the body's inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological p…
View article: Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes
Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes Open
View article: Reviewer #2 (Public Review): RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
Reviewer #2 (Public Review): RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages play a critical role in the body's inflammatory response, and their functions are tightly regulated to ensure optimal immune system function. Here we show that RAS-p110α signalling, a pathway crucially involved in several biolo…
View article: Reviewer #1 (Public Review): RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
Reviewer #1 (Public Review): RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages play a critical role in the body's inflammatory response, and their functions are tightly regulated to ensure optimal immune system function. Here we show that RAS-p110α signalling, a pathway crucially involved in several biolo…
View article: RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS–p110α signalling pathway, known for its involvement in various biological p…
View article: RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation
RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation Open
Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS-p110α signalling pathway, known for its involvement in various biological p…
View article: Supplementary Figure 7 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
Supplementary Figure 7 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate Open
Supplementary Figure 7 shows representative images of each phenotype
View article: FIGURE 2 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
FIGURE 2 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate Open
VCAN is associated with T-cell localization. A, Matrix index from Pearce and colleagues (14). Arrows indicate upregulation or downregulation at gene (G) or protein (P) level. B, Level of gene expression of top five upregulate…
View article: Data from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
Data from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate Open
Immunotherapies for cancers of epithelial origin have limited efficacy, and a growing body of evidence links the composition of extracellular matrix (ECM) with the likelihood of a favorable response to treatment. The ECM may be considered …
View article: Supplementary Figure 3 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
Supplementary Figure 3 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate Open
Supplementary Figure 3 describes the transwell model
View article: Supplementary Figure 1 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
Supplementary Figure 1 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate Open
Supplementary Figure 1 shows how VCAN was enriched and mass spectrometry analysis of the sample
View article: FIGURE 1 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
FIGURE 1 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate Open
Determining the immune phenotype of tumor tissues. A total of 26 TNBC tissues were analyzed for the TIP. A, Annotation of slide on QuPath for analysis of the four regions: Stroma, Outer Invasive, Inner Invasive, and Tumor Core. Numb…
View article: Supplementary Figure 5 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
Supplementary Figure 5 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate Open
Supplementary Figure 5 outlines the analysis of matrix proteins in TMAs.
View article: FIGURE 4 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
FIGURE 4 from Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate Open
Expression of VCAN in tissues and cells. A, VCAN protein expression from IHC compared with gene expression from RNAscope. Spearman rank correlation. B, Comparison of FAP+ cells and percentage of α-SMA staining with…