Viola Dreyer
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View article: Screening and targeted sequencing of stool for microbiologic confirmation and drug resistance determination in paucibacillary tuberculosis
Screening and targeted sequencing of stool for microbiologic confirmation and drug resistance determination in paucibacillary tuberculosis Open
In 2023, an estimated 10.8 million people developed tuberculosis, and 1.25 million people died from this disease, including 161,000 deaths in people with HIV (PWH) in whom tuberculosis remains the leading cause of death. Detecting Mycobact…
View article: Risk Factors Associated With Tuberculosis Infection Among Household Contacts of Patients With Microbiologically Confirmed Pulmonary Tuberculosis in 3 High Tuberculosis Burden Countries
Risk Factors Associated With Tuberculosis Infection Among Household Contacts of Patients With Microbiologically Confirmed Pulmonary Tuberculosis in 3 High Tuberculosis Burden Countries Open
Background Although tuberculosis preventive therapy guidelines support testing for tuberculosis infection in household contacts (HHCs), this adds operational complexity and cost and has often been abandoned. To understand utility of testin…
View article: Sex Differences in Vaccine-Induced Immunity and Protection Against <i>Mycobacterium tuberculosis</i>
Sex Differences in Vaccine-Induced Immunity and Protection Against <i>Mycobacterium tuberculosis</i> Open
Tuberculosis (TB) remains a leading global cause of death, with approximately 1.3 million fatalities annually. While males are more susceptible to TB, the underlying immune differences and their impact on vaccine efficacy are not fully und…
View article: Rapid Diagnostic Sequencing of Stool DNA Using Targeted Nanopore Sequencing in Patients With a Pulmonary Tuberculosis Diagnosis
Rapid Diagnostic Sequencing of Stool DNA Using Targeted Nanopore Sequencing in Patients With a Pulmonary Tuberculosis Diagnosis Open
Background Approximately 1.25 million individuals died of tuberculosis in 2023, in part due to ineffective treatment. In patients with paucibacillary tuberculosis, microbiologic confirmation and drug resistance testing via respiratory spec…
View article: Genome-wide analyses of Mycobacterium tuberculosis complex isolates reveal insights into circulating lineages and drug resistance mutations in The Gambia
Genome-wide analyses of Mycobacterium tuberculosis complex isolates reveal insights into circulating lineages and drug resistance mutations in The Gambia Open
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC), remains a pressing global health challenge, with the West African region, including The Gambia, experiencing a substantial burden. This study explores the genetic …
View article: Pathogen and host determinants of extrapulmonary tuberculosis among 1035 patients in Frankfurt am Main, Germany, 2008–2023
Pathogen and host determinants of extrapulmonary tuberculosis among 1035 patients in Frankfurt am Main, Germany, 2008–2023 Open
Our results demonstrate that host factors, such as geographic origin, age, and sex are stronger predictors for EPTB than infection with an Mtbc strain of a particular lineage. Further investigation of this host-pathogen interaction is need…
View article: Determinants of tuberculosis site among 1035 cases in Frankfurt, 2008-2023: does lineage matter?
Determinants of tuberculosis site among 1035 cases in Frankfurt, 2008-2023: does lineage matter? Open
Extrapulmonary tuberculosis (EPTB) presents with nonspecific symptoms which can pose a diagnostic challenge. Currently, there are no clear predictors for EPTB. We aimed to identify these factors for better diagnosis and disease control. We…
View article: EnteroBase in 2025: exploring the genomic epidemiology of bacterial pathogens
EnteroBase in 2025: exploring the genomic epidemiology of bacterial pathogens Open
This paper presents an update on the content, accessibility and analytical tools of the EnteroBase platform for web-based pathogen genome analysis. EnteroBase provides manually curated databases of genome sequence data and associated metad…
View article: First detection of a Mycobacterium tuberculosis XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023
First detection of a Mycobacterium tuberculosis XDR clinical isolate harbouring an RpoB I491F mutation in a Ukrainian patient treated in Germany, October 2023 Open
This report documents the case of a Ukrainian patient infected with an extensively drug-resistant (XDR) lineage 2 Mycobacterium tuberculosis strain harbouring the rifampicin resistance mutation RpoB I491F. This mutation is not detected by …
View article: Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia
Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia Open
Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background reg…
View article: Challenging the gold standard: the limitations of molecular assays for detection of<i>Mycobacterium tuberculosis</i>heteroresistance
Challenging the gold standard: the limitations of molecular assays for detection of<i>Mycobacterium tuberculosis</i>heteroresistance Open
Objectives Heteroresistant infections are defined as infections in which a mixture of drug-resistant and drug-susceptible populations are present. In Mycobacterium tuberculosis ( M. tb ), heteroresistance poses a challenge in diagnosis and…
View article: Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach Open
The World Health Organization has a goal of universal drug susceptibility testing for patients with tuberculosis. However, molecular diagnostics to date have focused largely on first-line drugs and predicting susceptibilities in a binary m…
View article: Impact of Mycobacterium tuberculosis strain type on multidrug-resistant tuberculosis severity, Republic of Moldova
Impact of Mycobacterium tuberculosis strain type on multidrug-resistant tuberculosis severity, Republic of Moldova Open
To the Editor,
View article: Implementation of targeted next-generation sequencing for the diagnosis of drug-resistant tuberculosis in low-resource settings: a programmatic model, challenges, and initial outcomes
Implementation of targeted next-generation sequencing for the diagnosis of drug-resistant tuberculosis in low-resource settings: a programmatic model, challenges, and initial outcomes Open
Targeted next-generation sequencing (tNGS) from clinical specimens has the potential to become a comprehensive tool for routine drug-resistance (DR) prediction of Mycobacterium tuberculosis complex strains (MTBC), the causative agent of tu…
View article: Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome <i>bc</i> <sub>1</sub> Complex
Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome <i>bc</i> <sub>1</sub> Complex Open
Drug-resistant tuberculosis is a global health care threat calling for novel effective treatment options. Here, we report on two novel cytochrome bc 1 inhibitors (MJ-22 and B6) targeting the Mycobacterium tuberculosis respiratory chain wit…
View article: Limited Nosocomial Transmission of Drug-Resistant Tuberculosis, Moldova
Limited Nosocomial Transmission of Drug-Resistant Tuberculosis, Moldova Open
Applying whole-genome-sequencing, we aimed to detect transmission events of multidrug-resistant/rifampin-resistant strains of Mycobacterium tuberculosis complex at a tuberculosis hospital in Chisinau, Moldova. We recorded ward, room, and b…
View article: Whole-Genome Sequencing for Resistance Prediction and Transmission Analysis of Mycobacterium tuberculosis Complex Strains from Namibia
Whole-Genome Sequencing for Resistance Prediction and Transmission Analysis of Mycobacterium tuberculosis Complex Strains from Namibia Open
The transmission of drug-resistant tuberculosis (TB) is a major problem for global TB control. Using genome sequencing, we showed that 13% of the multidrug-resistant (MDR) M. tuberculosis complex strains from Namibia are already pre-extens…
View article: Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3
Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3 Open
Mycobacterium tuberculosis complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a data…
View article: Whole genome sequencing-based drug resistance predictions of multidrug-resistant <i>Mycobacterium tuberculosis</i> isolates from Tanzania
Whole genome sequencing-based drug resistance predictions of multidrug-resistant <i>Mycobacterium tuberculosis</i> isolates from Tanzania Open
Background Rifampicin- or multidrug-resistant (RR/MDR) Mycobacterium tuberculosis complex (MTBC) strains account for considerable morbidity and mortality globally. WGS-based prediction of drug resistance may guide clinical decisions, espec…