Viola Guardigni
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View article: Out-of-Hospital Treatment of Hepatitis C Increases Retention in Care among People Who Inject Drugs and Homeless Persons: An Observational Study
Out-of-Hospital Treatment of Hepatitis C Increases Retention in Care among People Who Inject Drugs and Homeless Persons: An Observational Study Open
Background. People who inject drugs (PWID) and homeless people represent now a large reservoir of Hepatitis C virus (HCV) infection. However, Hepatis C elimination programs can barely reach these subgroups of patients. We aimed to evaluate…
View article: Pre-Existing HBV and HCV Infections Do Not Affect COVID-19-Related Outcomes: An Observational Retrospective Study
Pre-Existing HBV and HCV Infections Do Not Affect COVID-19-Related Outcomes: An Observational Retrospective Study Open
Background: A better understanding of the interaction between SARS-CoV-2 infection and HBV or HCV hepatitis is very important. Objectives: We aimed to determine the prevalence and the impact of pre-existing HBV and HCV infections in patien…
View article: SARS-CoV-2 related pneumonia in an adult with cystic fibrosis: natural favourable clinical course or effective therapy?
SARS-CoV-2 related pneumonia in an adult with cystic fibrosis: natural favourable clinical course or effective therapy? Open
We report the case of a man affected by cystic fibrosis who developed a severe SARS-CoV-2 related pneumonia in March 2020. In addition to lopinavir/ritonavir and hydroxychloroquine, he was treated with two doses of tocilizumab, displaying …
View article: Chronic Viral Hepatitis Do Not Affect 2019 Novel Coronavirus Disease-Related Outcomes: An Observational Retrospective Study.
Chronic Viral Hepatitis Do Not Affect 2019 Novel Coronavirus Disease-Related Outcomes: An Observational Retrospective Study. Open
BACKGROUND: To date, data about prevalence and clinical impact of viral hepatitis in COVID-19 are scarce and conflicting.METHODS: We conducted an observational, retrospective study including all subjects tested positive for SARS-CoV-2 from…
View article: Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-CoV-2 infection: a multicentre cohort study (PREDI-CO study)
Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-CoV-2 infection: a multicentre cohort study (PREDI-CO study) Open
View article: Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study
Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study Open
Background We evaluated the incidence of invasive pulmonary aspergillosis among intubated patients with critical COVID-19 and evaluated different case definitions of invasive aspergillosis. Methods Prospective, multicenter study in adult p…
View article: Middle-Aged Men With HIV Have Diminished Accelerometry-Based Activity Profiles Despite Similar Lab-Measured Gait Speed: Pilot Study
Middle-Aged Men With HIV Have Diminished Accelerometry-Based Activity Profiles Despite Similar Lab-Measured Gait Speed: Pilot Study Open
Accelerometer-based assessment of gait speed and activity patterns are lower for asymptomatic men living with HIV compared with uninfected controls and may be useful as preclinical digital biomarkers that precede differences captured in la…
View article: USING WEARABLE ACTIVITY TRACKERS TO DETECT DIFFERENCES IN FREE-LIVING, VOLITIONAL ACTIVITY
USING WEARABLE ACTIVITY TRACKERS TO DETECT DIFFERENCES IN FREE-LIVING, VOLITIONAL ACTIVITY Open
Slower gait speed is a well-established indicator for increased risk of morbidity and mortality. However, gold standard measurement methods like the six-minute walk test (6MWT), are difficult to use in a clinical setting and may not captur…
View article: BIOMARKERS FOR ASYNCHRONOUS AGING IN CHRONIC HIV INFECTION
BIOMARKERS FOR ASYNCHRONOUS AGING IN CHRONIC HIV INFECTION Open
Human immunodeficiency virus (HIV)-infected individuals are at increased risk of age-associated functional impairment, even with effective antiretroviral therapy (ART). Whether accelerated aging occurs in chronic HIV infection and the biol…
View article: Adipokines levels in HIV infected patients: lipocalin-2 and fatty acid binding protein-4 as possible markers of HIV and antiretroviral therapy-related adipose tissue inflammation
Adipokines levels in HIV infected patients: lipocalin-2 and fatty acid binding protein-4 as possible markers of HIV and antiretroviral therapy-related adipose tissue inflammation Open
View article: Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults
Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults Open
NCT03011957.
View article: Multiplexed therapeutic drug monitoring (TDM) of antiviral drugs by LC–MS/MS
Multiplexed therapeutic drug monitoring (TDM) of antiviral drugs by LC–MS/MS Open
View article: Liver decompensation predicts ribavirin overexposure in hepatitis C virus patients treated with direct-acting antivirals
Liver decompensation predicts ribavirin overexposure in hepatitis C virus patients treated with direct-acting antivirals Open
Liver decompensation might affect RBV clearance leading to an overexposure and increased related toxicities in decompensated cirrhosis. Our findings underscore the importance of an early ribavirin therapeutic drug monitoring and suggest th…
View article: Early Onset of Tenofovir-Related Fanconi Syndrome in a Child with Acute Hepatitis B: A Case Report and Systematic Review of Literature
Early Onset of Tenofovir-Related Fanconi Syndrome in a Child with Acute Hepatitis B: A Case Report and Systematic Review of Literature Open
Tenofovir disoproxil fumarate- (TDF-) related nephropathy is known to be a long-term complication of this drug, more commonly observed in HIV-infected patients, but occurring also in hepatitis B. Cases of Fanconi Syndrome associated with T…
View article: Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review
Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review Open
We present here the case of a 66 year old man with a severe bilateral community acquired pneumonia secondary to dissemination after an intravesical instillation of bacilllus Calmette-Guérin (BCG). Diagnosis was based on positive polymerase…