Viola Hollek
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View article: Investigating genetic modifications to enhance L1CAM-CAR T cell migration in solid tumors in a 3D bioprinted neuroblastoma model
Investigating genetic modifications to enhance L1CAM-CAR T cell migration in solid tumors in a 3D bioprinted neuroblastoma model Open
Introduction Effective CAR T cell infiltration into solid tumors remains a major barrier to therapy success. Despite their clinical potential, few studies have evaluated phenotypes of CAR T cells successfully invading the tumor mass follow…
View article: Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma
Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma Open
Resistance to targeted therapies develops in the majority of patients, with numerous different mechanisms having been documented. This is frequently linked to intra-tumour heterogeneity and cancer cells transitioning into different states.…