Viola Lam
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View article: 278 Preclinical development of LYL119, a ROR1-targeted CAR T-cell product incorporating four novel T-cell reprogramming technologies to overcome barriers to effective cell therapy for solid tumors
278 Preclinical development of LYL119, a ROR1-targeted CAR T-cell product incorporating four novel T-cell reprogramming technologies to overcome barriers to effective cell therapy for solid tumors Open
Background Effective solid tumor cell therapy requires new strategies to improve T-cell activation, persistence, and durable function.1 2 We developed four complementary, stackable T-cell reprogramming technologies to enhance chimeric anti…
View article: 232 Increased potency and functional persistence <i>in vitro</i> of a next-generation NY-ESO-1-specific TCR therapy incorporating Gen-R™ genetic reprogramming technology
232 Increased potency and functional persistence <i>in vitro</i> of a next-generation NY-ESO-1-specific TCR therapy incorporating Gen-R™ genetic reprogramming technology Open
Background Letetresgene autoleucel (lete-cel; GSK3377794) is a first-generation (1st gen) NY-ESO-1-specific T-cell receptor (TCR) therapy with demonstrated clinical activity in solid tumors.1-2 Next-generation T-cell therapies are in devel…
View article: 243 NR4A3 gene editing and c-Jun overexpression synergize to limit exhaustion and enhance functional activity of ROR1 CAR T cells <i>in vitro</i> and <i>in vivo</i>
243 NR4A3 gene editing and c-Jun overexpression synergize to limit exhaustion and enhance functional activity of ROR1 CAR T cells <i>in vitro</i> and <i>in vivo</i> Open
Background Next-generation strategies to improve T-cell functional activity, persistence, and durability are needed for effective cellular immunotherapy against solid tumors. Overexpression of the activator protein 1 (AP-1) family transcri…
View article: KLF12 Regulates Mouse NK Cell Proliferation
KLF12 Regulates Mouse NK Cell Proliferation Open
NK cells are innate lymphocytes that play an integral role in tumor rejection and viral clearance. Unlike their other lymphocyte counterparts, NK cells have the unique ability to recognize and lyse target cells without prior exposure. Howe…
View article: Natural Killer Cell-specific Genes: Klf12 and Spry2
Natural Killer Cell-specific Genes: Klf12 and Spry2 Open
Natural killer (NK) cells are innate lymphocytes that play in integral role in tumor rejection and viral clearance. Unlike their lymphocyte counterparts, NK cells have the unique ability to recognize and lyse target cells without prior exp…